Leucosceptrane Sesterterpenoids as a New Type of Natural Immunosuppressive Agents in Treating Sepsis

doi:10.1021/acs.jmedchem.3c01759

KIB OpenIR

	Leucosceptrane Sesterterpenoids as a New Type of Natural Immunosuppressive Agents in Treating Sepsis
	Guo,Kai; Zhou,Ting-Ting; Luo,Shi-Hong; Liu,Yan-Chun; Liu,Yan; Li,Sheng-Hong
	2023
发表期刊	JOURNAL OF MEDICINAL CHEMISTRY
ISSN	1520-4804
卷号	67 期号:1 页码:513-528
摘要	Intragastric administration of the total sesterterpenoid extract (TSE) of medicinal plant Leucosceptrum canum at 2.5 g/kg dose protected mice from LPS-induced sepsis. Phytochemical investigation led to the isolation and identification of 47 leucosceptrane sesterterpenoids (1-47) including 30 new compounds (1-30) with complicated oxygenation patterns. Biological screening indicated their immunosuppressive activity via inhibiting IFN-gamma secretion and/or proliferation of T cells with different potencies. Mechanism study of compounds 9, 25, and 32 revealed that they inhibited the activations of AKT-mTOR, JNK, p38 MAPK or ERK pathway in T cells and macrophages. In addition, compounds 9 and 25 induced G0/G1 cell arrest of T cells. The major component, leucosceptroid N (32), significantly lowered the levels of IL-6 and TNF-alpha in peripheral blood serum, and ameliorated the multiorgan damages of LPS-induced sepsis mice at 25 mg/kg dose. These findings suggest that leucosceptrane sesterterpenoids are a new type of potential immunosuppressive agents for sepsis treatment.
关键词	GLANDULAR TRICHOMES PRODUCTS HARBOR CANUM
学科领域	193
DOI	10.1021/acs.jmedchem.3c01759
收录类别	SCI
WOS记录号	WOS:001141744000001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75295
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Guo,Kai,Zhou,Ting-Ting,Luo,Shi-Hong,et al. Leucosceptrane Sesterterpenoids as a New Type of Natural Immunosuppressive Agents in Treating Sepsis[J]. JOURNAL OF MEDICINAL CHEMISTRY,2023,67(1):513-528.
APA	Guo,Kai,Zhou,Ting-Ting,Luo,Shi-Hong,Liu,Yan-Chun,Liu,Yan,&Li,Sheng-Hong.(2023).Leucosceptrane Sesterterpenoids as a New Type of Natural Immunosuppressive Agents in Treating Sepsis.JOURNAL OF MEDICINAL CHEMISTRY,67(1),513-528.
MLA	Guo,Kai,et al."Leucosceptrane Sesterterpenoids as a New Type of Natural Immunosuppressive Agents in Treating Sepsis".JOURNAL OF MEDICINAL CHEMISTRY 67.1(2023):513-528.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
10.1021_acs.jmedchem（12263KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览下载