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Design, synthesis and biological evaluation of novel copper-chelating acetylcholinesterase inhibitors with pyridine and N-benzylpiperidine fragments 期刊论文
BIOORGANIC CHEMISTRY, 2019, 卷号: 93, 页码: 13
作者:  Zhou, Yeheng;  Sun, Wei;  Peng, Jiale;  Yan, Hui;  Zhang, Li;  Liu, Xingyong;  Zuo, Zhili
Adobe PDF(4739Kb)  |  收藏  |  浏览/下载：181/29  |  提交时间：2020/03/18
Acetylcholinesterase  Drug design  N-acylhydrazone  Dementia  Copper-chelating  N-Benzylpiperidine  
Fine-Tuning of Shh/Gli Signaling Gradient by Non-proteolytic Ubiquitination during Neural Patterning 期刊论文
CELL REPORTS, 2019, 卷号: 28, 期号: 2, 页码: 541-+
作者:  Ma, Pengcheng;  Song, Ning-Ning;  Li, Yongxin;  Zhang, Qiong;  Zhang, Lei;  Zhang, Longlong;  Kong, Qinghua;  Ma, Li;  Yang, Xiangcai;  Ren, Biyu;  Li, Chaocui;  Zhao, Xudong;  Li, Yan;  Xu, Ying;  Gao, Xiang;  Ding, Yu-Qiang;  Mao, Bingyu
Adobe PDF(5547Kb)  |  收藏  |  浏览/下载：223/41  |  提交时间：2019/08/19
The natural product antroalbol H promotes phosphorylation of liver kinase B1 (LKB1) at threonine 189 and thereby enhances cellular glucose uptake 期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2019, 卷号: 294, 期号: 27, 页码: 10415-10427
作者:  Wang, Fang;  Yang, Xiaoyan;  Lu, Yanting;  Li, Zhenghui;  Xu, Yuhui;  Hu, Jing;  Liu, Jikai;  Xiong, Wenyong
Adobe PDF(4461Kb)  |  收藏  |  浏览/下载：225/68  |  提交时间：2019/09/10
glucose metabolism  liver kinase B1 (LKB1)  AMP-activated kinase (AMPK)  glucose transporter type 4 (GLUT4)  fungi  Basidiomycete  diabetes  energy sensing  glucose homeostasis  sesquiterpene  
Aqueous extract of clove inhibits tumor growth by inducing autophagy through AMPK/ULK pathway 期刊论文
PHYTOTHERAPY RESEARCH, 2019, 卷号: 33, 期号: 7, 页码: 1794-1804
作者:  Li, Cong;  Xu, Huanli;  Chen, Xiaoliang;  Chen, Jijun;  Li, Xiao;  Qiao, Gan;  Tian, Ye;  Yuan, Ru;  Su, Shuonan;  Liu, Xiaohui;  Lin, Xiukun
Adobe PDF(1218Kb)  |  收藏  |  浏览/下载：163/43  |  提交时间：2019/09/10
AMPK  anticancer  aqueous extract of clove  autophagy  traditional Chinese medicine  
NCP activates chloroplast transcription by controlling phytochrome-dependent dual nuclear and plastidial switches 期刊论文
NATURE COMMUNICATIONS, 2019, 卷号: 10, 页码: 13
作者:  Yang, Emily J.;  Yoo, Chan Yul;  Liu, Jiangxin;  Wang, He;  Cao, Jun;  Li, Fay-Wei;  Pryer, Kathleen M.;  Sun, Tai-ping;  Weigel, Detlef;  Zhou, Pei;  Chen, Meng
Adobe PDF(2676Kb)  |  收藏  |  浏览/下载：124/13  |  提交时间：2019/07/29
A metabolomic perspective of pazopanib-induced acute hepatotoxicity in mice 期刊论文
XENOBIOTICA, 2019, 卷号: 49, 期号: 6, 页码: 655-670
作者:  Wang, Yi-Kun;  Yang, Xiao-Nan;  Liang, Wei-Qing;  Xiao, Yao;  Zhao, Qi;  Xiao, Xue-Rong;  Gonzalez, Frank J.;  Li, Fei
Adobe PDF(1101Kb)  |  收藏  |  浏览/下载：232/103  |  提交时间：2019/07/29
Pazopanib  hepatotoxicity  metabolomics  oxidative stress  ultra-performance liquid chromatography-electrospray ion source-quadrupole  time-of-flight mass spectrometer (UPLC-ESI-QTOFMS)  
A new highly oxygenated abietane diterpenoid and a new lysosome generating phorbol ester from the roots of Euphorbia fischeriana Steud 期刊论文
NATURAL PRODUCT RESEARCH, 2019, 页码: 9
作者:  Adelakun, Tiwalade A.;  Ding, Xiao;  Ombati, Rose M.;  Zhao, Ning-Dong;  Obodozie-Ofoegbu, Obiageri;  Di, Ying-Tong;  Zhang, Yu;  Hao, Xiao-Jiang
浏览  |  Adobe PDF(1037Kb)  |  收藏  |  浏览/下载：282/139  |  提交时间：2019/07/29
Euphorbia fischeriana Steud  highly oxygenated abietanes  phorbol esters  lysosomal biogenesis  
B591, a novel specific pan-PI3K inhibitor, preferentially targets cancer stem cells 期刊论文
ONCOGENE, 2019, 卷号: 38, 期号: 18, 页码: 3371-3386
作者:  Zhou, Hongyu;  Yu, Chunlei;  Kong, Lingmei;  Xu, Xiaoliang;  Yan, Juming;  Li, Yingchao;  An, Tao;  Gong, Liang;  Gong, Yaxiao;  Zhu, Huifang;  Zhang, Hongbin;  Yang, Xiaodong;  Li, Yan
浏览  |  Adobe PDF(5225Kb)  |  收藏  |  浏览/下载：233/27  |  提交时间：2019/06/24
Nonasaccharide Inhibits Intrinsic Factor Xase Complex by Binding to Factor IXa and Disrupting Factor IXa-Factor VIIIa Interactions 期刊论文
THROMBOSIS AND HAEMOSTASIS, 2019, 卷号: 119, 期号: 5, 页码: 705-715
作者:  Xiao, Chuang;  Zhao, Longyan;  Gao, Na;  Wu, Mingyi;  Zhao, Jinhua
浏览  |  Adobe PDF(740Kb)  |  收藏  |  浏览/下载：228/59  |  提交时间：2019/06/24
nonasaccharide from fucosylated glycosaminoglycan  intrinsic factor Xase complex  factor IXa  anticoagulant  
Identification of potential AMPK activator by pharmacophore modeling, molecular docking and QSAR study 期刊论文
COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2019, 卷号: 79, 页码: 165-176
作者:  Li, Yingying;  Peng, Jiale;  Li, Penghua;  Du, Haibo;  Li, Yaping;  Liu, Xingyong;  Zhang, Li;  Wang, Liang-Liang;  Zuo, Zhili
浏览  |  Adobe PDF(7335Kb)  |  收藏  |  浏览/下载：231/25  |  提交时间：2019/07/29
Pharmacophore modeling  Molecular docking  Quantitative structure activity relationship (QSAR)  Molecular dynamics  AMPK  Activator