Fine-Tuning of Shh/Gli Signaling Gradient by Non-proteolytic Ubiquitination during Neural Patterning
Ma, Pengcheng1; Song, Ning-Ning2,3; Li, Yongxin1,11; Zhang, Qiong4; Zhang, Lei4; Zhang, Longlong1,11; Kong, Qinghua1,10; Ma, Li1,12; Yang, Xiangcai1; Ren, Biyu1,7; Li, Chaocui1; Zhao, Xudong8,9; Li, Yan10; Xu, Ying5,6; Gao, Xiang5,6; Ding, Yu-Qiang2,3,4; Mao, Bingyu1,9
通讯作者Gao, Xiang(gaoxiang@nju.edu.cn) ; Ding, Yu-Qiang(dingyuqiang@vip.163.com) ; Mao, Bingyu(mao@mail.kiz.ac.cn)
2019-07-09
发表期刊CELL REPORTS
ISSN2211-1247
卷号28期号:2页码:541-+
摘要Sonic Hedgehog (Shh) signaling plays crucial roles in patterning the ventral neural tube, which is transformed into opposing gradients of repressor and activator forms of Glis. Here, we show that the fine-tuning of the shape of the Gli gradients through non-proteolytic ubiquitination-mediated nuclear exportation plays an important role in the control of local neural cell fate. Loss of RNF220, a ventral neural-specific ubiquitin E3 ligase, leads to ventral expansion of the intermediate V0 and dorsal expansion of the ventral V3 neurons, while reducing the V1, V2, and motor neurons between them. We show that RNF220 interacts with all Glis, either in their activator or repressor forms; induces their K63-linked ubiquitination; and promotes their nuclear export, likely by unmasking a nuclear export signal in the zinc finger domain. We propose that RNF220 works to refine the Gli gradients during neural patterning by limiting the effective Gli levels in the nucleus.
DOI10.1016/j.celrep.2019.06.017
收录类别SCI
语种英语
WOS记录号WOS:000474580800021
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/67970
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Gao, Xiang; Ding, Yu-Qiang; Mao, Bingyu
作者单位1.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650223, Yunnan, Peoples R China
2.Fudan Univ, Inst Brain Sci, State Key Lab Med Neurobiol, Shanghai 200032, Peoples R China
3.Fudan Univ, Inst Brain Sci, MOE Frontiers Ctr Brain Sci, Shanghai 200032, Peoples R China
4.Tongji Univ, East Hosp, Dept Anat & Neurobiol, Sch Med,Key Lab Arrhythmias,Minist Educ China, Shanghai 200092, Peoples R China
5.Nanjing Univ, Model Anim Res Ctr, State Key Lab Pharmaceut Biotechnol, Nanjing 210061, Jiangsu, Peoples R China
6.Nanjing Univ, Model Anim Res Ctr, Key Lab Model Anim Dis Study, Minist Educ, Nanjing 210061, Jiangsu, Peoples R China
7.Anhui Univ, Inst Hlth Sci, Hefei 230601, Anhui, Peoples R China
8.Chinese Acad Sci & Yunnan Prov, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China
9.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China
10.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
11.Univ Chinese Acad Sci, Kunming Coll Life Sci, Kunming 650203, Yunnan, Peoples R China
12.Univ Maryland, Dept Biol, College Pk, MD 20742 USA
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Ma, Pengcheng,Song, Ning-Ning,Li, Yongxin,et al. Fine-Tuning of Shh/Gli Signaling Gradient by Non-proteolytic Ubiquitination during Neural Patterning[J]. CELL REPORTS,2019,28(2):541-+.
APA Ma, Pengcheng.,Song, Ning-Ning.,Li, Yongxin.,Zhang, Qiong.,Zhang, Lei.,...&Mao, Bingyu.(2019).Fine-Tuning of Shh/Gli Signaling Gradient by Non-proteolytic Ubiquitination during Neural Patterning.CELL REPORTS,28(2),541-+.
MLA Ma, Pengcheng,et al."Fine-Tuning of Shh/Gli Signaling Gradient by Non-proteolytic Ubiquitination during Neural Patterning".CELL REPORTS 28.2(2019):541-+.
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