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Structurally modified Cyclovirobuxine-D Buxus alkaloids as effective analgesic agents through Cav3.2 T-Type calcium channel inhibition 期刊论文
BIOORGANIC CHEMISTRY, 2023, 卷号: 135, 页码: 106493
作者:  Munikishore,Rachakunta;  Liu,Rui;  Zhang,Shuqun;  Zhao,Qin-Shi;  Nian,Yin;  Zuo,Zhili
浏览  |  Adobe PDF(5035Kb)  |  收藏  |  浏览/下载：49/9  |  提交时间：2024/07/22
Buxus alkaloid  Structural modification  T -type calcium channel  Analgesic activity  Docking analysis  Structure -activity relationship study  BUXOZINE-C  SEMPERVIRENS  RING  CONSTITUTION  
Isolation and identification of hemostatic steroidal glycosides from Ypsilandra thibetica 期刊论文
BIOORGANIC CHEMISTRY, 2023, 卷号: 130, 页码: 106268
作者:  Ma,Wen-Yi;  Xie,Jing;  Yu,Ling-Ling;  Zhang,Shi-Juan;  Ni,Wei;  Yan,Huan;  Liu,Hai-Yang
浏览  |  Adobe PDF(2307Kb)  |  收藏  |  浏览/下载：57/12  |  提交时间：2024/07/22
Ypsilandra thibetica  Steroidal saponins  Ypsilandrosides Z1-Z14  Hemostatic activity  Structure-activity relationship  SPIROSTANE GLYCOSIDES  NMR-SPECTROSCOPY  AGGREGATION  SAPOGENINS  SAPONINS  
Diverse aspidosperma-type alkaloids from the leaves of Tabernaemontana bovina with anti-hepatoma activity 期刊论文
FITOTERAPIA, 2023, 卷号: 169, 页码: 105588
作者:  Yu,Yang;  Wu,Jing;  Bao,Mei-Fen;  Schinnerl,Johann;  Cai,Xiang-Hai
浏览  |  Adobe PDF(2185Kb)  |  收藏  |  浏览/下载：22/4  |  提交时间：2024/07/25
Tabernaemontana bovina  Apocynaceae  Aspidosperma alkaloids  Taberbovermines  Hepatom  Structure -activity relationship  BISINDOLE ALKALOIDS  INDOLE ALKALOIDS  LEUCONOXINE  
岩藻糖化糖胺聚糖 系统给药的毒性作用及其相关的血小板激活作用与机制 学位论文
: 中国科学院大学, 2022
作者:  林丽莎
Adobe PDF(5816Kb)  |  收藏  |  浏览/下载：66/0  |  提交时间：2024/05/14
岩藻糖化糖胺聚糖，毒性机制，血小板聚集，构效关系，血小板受体  Fucosylated glycosaminoglycan, Toxic effect, Platelet aggregation, Structure-activity relationship, Platelet receptor  
Anti-Adipogenic Lanostane-Type Triterpenoids from the Edible and Medicinal Mushroom Ganoderma applanatum 期刊论文
JOURNAL OF FUNGI, 2022, 卷号: 8, 期号: 4, 页码: 331
作者:  Peng, Xing-Rong;  Wang, Qian;  Su, Hai-Guo;  Zhou, Lin;  Xiong, Wen-Yong;  Qiu, Ming-Hua
浏览  |  Adobe PDF(4854Kb)  |  收藏  |  浏览/下载：78/11  |  提交时间：2024/04/30
Ganoderma applanatum  lanostane triterpenoid  Mosher's method  anti-adipogenesis activity  structure-activity relationship  APOPTOSIS  LUCIDUM  INFLAMMATION  METABOLISM  EXTRACTS  PROVIDE  BODY  
Polycyclic polyprenylated acylphloroglucinol derivatives with neuroprotective effects from Hypericum monogynum 期刊论文
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2021, 卷号: 23, 期号: 1, 页码: 73-81
作者:  Zeng,Yan-Rong;  Li,Ya-Na;  Lou,Hua-Yong;  Jian,Jun-You;  Gu,Wei;  Huang,Lie-Jun;  Du,Guan-Hua;  Yuan,Chun-Mao;  Hao,Xiao-Jiang
收藏  |  浏览/下载：115/0  |  提交时间：2022/04/02
Hypericum monogynum  polycyclic polyprenylated acylphloroglucinols (PPAPs)  neuroprotective effects  structure-activity relationship  ST JOHNS WORT  PHLOROGLUCINOL DERIVATIVES  PRENYLATED PHLOROGLUCINOL  HYPERFORIN  ANALOGS  
Structures/cytotoxicity/selectivity relationship of natural steroidal saponins against GSCs and primary mechanism of tribulosaponin A 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 210, 页码: 113068
作者:  Dai,Zhi;  Liu,Hui;  Wang,Bei;  Yang,Dong;  Zhu,Yan-Yan;  Yan,Huan;  Zhu,Pei-Feng;  Liu,Ya-Ping;  Chen,Hui-Cheng;  Zhao,Yun-li;  Zhao,Li-Xing;  Zhao,Xu-Dong;  Liu,Hai-Yang;  Luo,Xiao-Dong
浏览  |  Adobe PDF(2630Kb)  |  收藏  |  浏览/下载：235/96  |  提交时间：2022/04/02
Steroidal saponins  Structure-activity relationship  Tribulosaponin A  Glioma stem cells  ROS  SMALL MOLECULES  CARDIAC-ARREST  STEM-CELL  IDENTIFICATION  THERAPY  BRAIN  OPPORTUNITIES  GLIOMA  TUMORS  NOX2  
Discovery of pseudolaric acid A as a new Hsp90 inhibitor uncovers its potential anticancer mechanism 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 112, 页码: 104963
作者:  Liu,Jiangxin;  Wu,Xing-De;  Li,Wenyan;  Yuan,Zaifeng;  Yang,Kun;  Zhao,Qin-Shi
浏览  |  Adobe PDF(3665Kb)  |  收藏  |  浏览/下载：115/19  |  提交时间：2022/04/02
Pseudolaric acid A  Hsp90 inhibitor  Apoptosis  NMR  Structure-activity relationship  Photoaffinity-based probe  Protein-ligand interaction  MOLECULAR CHAPERONE  PROTEIN  TARGET  CANCER  KINASE  NMR  IDENTIFICATION  SELECTIVITY  BINDING  DESIGN  
Polycyclic polyprenylated acylphloroglucinol derivatives with neuroprotective effects from Hypericum monogynum 期刊论文
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2019, 页码: 9
作者:  Zeng, Yan-Rong;  Li, Ya-Na;  Lou, Hua-Yong;  Jian, Jun-You;  Gu, Wei;  Huang, Lie-Jun;  Du, Guan-Hua;  Yuan, Chun-Mao;  Hao, Xiao-Jiang
浏览  |  Adobe PDF(1233Kb)  |  收藏  |  浏览/下载：326/60  |  提交时间：2020/03/18
Hypericum monogynum  polycyclic polyprenylated acylphloroglucinols (PPAPs)  neuroprotective effects  structure-activity relationship  
Cytotoxic phenolic constituents from Hypericum japonicum 期刊论文
PHYTOCHEMISTRY, 2019, 卷号: 164, 页码: 33-40
作者:  Zhu, Wei;  Qiu, Jie;  Zeng, Yan-Rong;  Yi, Ping;  Lou, Hua-Yong;  Jian, Jun-You;  Zuo, Ming-Xing;  Duan, Lian;  Gu, Wei;  Huang, Lie-Jun;  Li, Yan-Mei;  Yuan, Chun-Mao;  Hao, Xiao-Jiang
浏览  |  Adobe PDF(902Kb)  |  收藏  |  浏览/下载：470/204  |  提交时间：2019/09/10
Hypericum japonicum thunb. (Hypericaceae)  Phenolic compounds  Xanthone and flavonoid derivatives  Cytotoxic activities  Structure-activity relationship