Polycyclic polyprenylated acylphloroglucinol derivatives with neuroprotective effects from Hypericum monogynum

doi:10.1080/10286020.2019.1698551

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	Polycyclic polyprenylated acylphloroglucinol derivatives with neuroprotective effects from Hypericum monogynum
	Zeng,Yan-Rong ; Li,Ya-Na ; Lou,Hua-Yong ; Jian,Jun-You ; Gu,Wei; Huang,Lie-Jun ; Du,Guan-Hua ; Yuan,Chun-Mao ; Hao,Xiao-Jiang
	2021
发表期刊	JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
ISSN	1028-6020
卷号	23 期号:1 页码:73-81
摘要	A new polycyclic polyprenylated acylphloroglucinol (PPAP), hypermonin C (1), along with nine known PPAPs (2-10) were obtained from the leaves and twigs of Hypericum monogynum. The structures of the isolates were determined on the basis of extensive spectroscopic analysis. The neuroprotective effects of the isolates against several chemical-induced injuries in SH-SY5Y and PC12 cells were assessed, and most of the compounds exhibited significant protective effects at 10 mu g/ml. Especially, three compounds (1, 3, and 7) showed excellent neuroprotective activity with a cell viability of 92.4% similar to 95.8% in KCl-induced SH-SY5Y cell injury. Their preliminary structure-activity relationship was also discussed and the configuration of substituent in furohyperforin may be critical for the neuroprotective activity of PPAP derivatives.
关键词	Hypericum monogynum polycyclic polyprenylated acylphloroglucinols (PPAPs) neuroprotective effects structure-activity relationship ST JOHNS WORT PHLOROGLUCINOL DERIVATIVES PRENYLATED PHLOROGLUCINOL HYPERFORIN ANALOGS
DOI	10.1080/10286020.2019.1698551
WOS记录号	WOS:000502731100001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73102
专题	中国科学院昆明植物研究所
作者单位	1.[Zeng, Yan-Rong 2.Li, Ya-Na 3.Lou, Hua-Yong 4.Jian, Jun-You 5.Gu, Wei 6.Huang, Lie-Jun 7.Yuan, Chun-Mao 8.Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550014, Guizhou, Peoples R China 9.Guizhou Med Univ, Coll Basic Med, Guiyang 550004, Guizhou, Peoples R China 10.Chinese Acad Sci, Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550014, Guizhou, Peoples R China 11.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 12.Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, Beijing Key Lab Drug Target Identificat & Drug S, Beijing 100050, Peoples R China
推荐引用方式 GB/T 7714	Zeng,Yan-Rong,Li,Ya-Na,Lou,Hua-Yong,et al. Polycyclic polyprenylated acylphloroglucinol derivatives with neuroprotective effects from Hypericum monogynum[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2021,23(1):73-81.
APA	Zeng,Yan-Rong.,Li,Ya-Na.,Lou,Hua-Yong.,Jian,Jun-You.,Gu,Wei.,...&Hao,Xiao-Jiang.(2021).Polycyclic polyprenylated acylphloroglucinol derivatives with neuroprotective effects from Hypericum monogynum.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,23(1),73-81.
MLA	Zeng,Yan-Rong,et al."Polycyclic polyprenylated acylphloroglucinol derivatives with neuroprotective effects from Hypericum monogynum".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 23.1(2021):73-81.