Polycyclic polyprenylated acylphloroglucinol derivatives with neuroprotective effects from Hypericum monogynum
Zeng, Yan-Rong1,2,3; Li, Ya-Na1,3; Lou, Hua-Yong1,2,3; Jian, Jun-You1,3; Gu, Wei1,3; Huang, Lie-Jun1,3; Du, Guan-Hua5; Yuan, Chun-Mao1,3; Hao, Xiao-Jiang1,2,3,4
Corresponding AuthorDu, Guan-Hua(dugh@imm.ac.cn) ; Yuan, Chun-Mao(yuanchunmao01@126.com) ; Hao, Xiao-Jiang(haoxj@mail.kib.ac.cn)
2019-12-13
Source PublicationJOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
ISSN1028-6020
Pages9
AbstractA new polycyclic polyprenylated acylphloroglucinol (PPAP), hypermonin C (1), along with nine known PPAPs (2-10) were obtained from the leaves and twigs of Hypericum monogynum. The structures of the isolates were determined on the basis of extensive spectroscopic analysis. The neuroprotective effects of the isolates against several chemical-induced injuries in SH-SY5Y and PC12 cells were assessed, and most of the compounds exhibited significant protective effects at 10 mu g/ml. Especially, three compounds (1, 3, and 7) showed excellent neuroprotective activity with a cell viability of 92.4% similar to 95.8% in KCl-induced SH-SY5Y cell injury. Their preliminary structure-activity relationship was also discussed and the configuration of substituent in furohyperforin may be critical for the neuroprotective activity of PPAP derivatives.
KeywordHypericum monogynum polycyclic polyprenylated acylphloroglucinols (PPAPs) neuroprotective effects structure-activity relationship
DOI10.1080/10286020.2019.1698551
Indexed BySCI ; SCI
Language英语
WOS IDWOS:000502731100001
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/70605
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorDu, Guan-Hua; Yuan, Chun-Mao; Hao, Xiao-Jiang
Affiliation1.Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550014, Guizhou, Peoples R China
2.Guizhou Med Univ, Coll Basic Med, Guiyang 550004, Guizhou, Peoples R China
3.Chinese Acad Sci, Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550014, Guizhou, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
5.Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, Beijing Key Lab Drug Target Identificat & Drug S, Beijing 100050, Peoples R China
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GB/T 7714
Zeng, Yan-Rong,Li, Ya-Na,Lou, Hua-Yong,et al. Polycyclic polyprenylated acylphloroglucinol derivatives with neuroprotective effects from Hypericum monogynum[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2019:9.
APA Zeng, Yan-Rong.,Li, Ya-Na.,Lou, Hua-Yong.,Jian, Jun-You.,Gu, Wei.,...&Hao, Xiao-Jiang.(2019).Polycyclic polyprenylated acylphloroglucinol derivatives with neuroprotective effects from Hypericum monogynum.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,9.
MLA Zeng, Yan-Rong,et al."Polycyclic polyprenylated acylphloroglucinol derivatives with neuroprotective effects from Hypericum monogynum".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH (2019):9.
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