| Polycyclic polyprenylated acylphloroglucinol derivatives with neuroprotective effects from Hypericum monogynum | |
Zeng, Yan-Rong1,2,3; Li, Ya-Na1,3; Lou, Hua-Yong1,2,3; Jian, Jun-You1,3; Gu, Wei1,3 ; Huang, Lie-Jun1,3; Du, Guan-Hua5; Yuan, Chun-Mao1,3; Hao, Xiao-Jiang1,2,3,4
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| 通讯作者 | Du, Guan-Hua(dugh@imm.ac.cn) ; Yuan, Chun-Mao(yuanchunmao01@126.com) ; Hao, Xiao-Jiang(haoxj@mail.kib.ac.cn) |
| 2019-12-13 | |
| 发表期刊 | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
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| ISSN | 1028-6020 |
| 页码 | 9 |
| 摘要 | A new polycyclic polyprenylated acylphloroglucinol (PPAP), hypermonin C (1), along with nine known PPAPs (2-10) were obtained from the leaves and twigs of Hypericum monogynum. The structures of the isolates were determined on the basis of extensive spectroscopic analysis. The neuroprotective effects of the isolates against several chemical-induced injuries in SH-SY5Y and PC12 cells were assessed, and most of the compounds exhibited significant protective effects at 10 mu g/ml. Especially, three compounds (1, 3, and 7) showed excellent neuroprotective activity with a cell viability of 92.4% similar to 95.8% in KCl-induced SH-SY5Y cell injury. Their preliminary structure-activity relationship was also discussed and the configuration of substituent in furohyperforin may be critical for the neuroprotective activity of PPAP derivatives. |
| 关键词 | Hypericum monogynum polycyclic polyprenylated acylphloroglucinols (PPAPs) neuroprotective effects structure-activity relationship |
| DOI | 10.1080/10286020.2019.1698551 |
| 收录类别 | SCI ; SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000502731100001 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/70605 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Du, Guan-Hua; Yuan, Chun-Mao; Hao, Xiao-Jiang |
| 作者单位 | 1.Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550014, Guizhou, Peoples R China 2.Guizhou Med Univ, Coll Basic Med, Guiyang 550004, Guizhou, Peoples R China 3.Chinese Acad Sci, Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550014, Guizhou, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 5.Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, Beijing Key Lab Drug Target Identificat & Drug S, Beijing 100050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zeng, Yan-Rong,Li, Ya-Na,Lou, Hua-Yong,et al. Polycyclic polyprenylated acylphloroglucinol derivatives with neuroprotective effects from Hypericum monogynum[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2019:9. |
| APA | Zeng, Yan-Rong.,Li, Ya-Na.,Lou, Hua-Yong.,Jian, Jun-You.,Gu, Wei.,...&Hao, Xiao-Jiang.(2019).Polycyclic polyprenylated acylphloroglucinol derivatives with neuroprotective effects from Hypericum monogynum.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,9. |
| MLA | Zeng, Yan-Rong,et al."Polycyclic polyprenylated acylphloroglucinol derivatives with neuroprotective effects from Hypericum monogynum".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH (2019):9. |
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| 10.1080@10286020.201（1233KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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