Cytotoxic phenolic constituents from Hypericum japonicum
Zhu, Wei1,2,3,4; Qiu, Jie1,2,3,4; Zeng, Yan-Rong1,3,4; Yi, Ping1,2,3,4; Lou, Hua-Yong1,3,4; Jian, Jun-You1,2,3,4; Zuo, Ming-Xing1,2,3,4; Duan, Lian1,2,3,4; Gu, Wei1,2,3,4; Huang, Lie-Jun1,2,3,4; Li, Yan-Mei1,2,3,4; Yuan, Chun-Mao1,2,3,4; Hao, Xiao-Jiang1,2,3,4,5
Corresponding AuthorLi, Yan-Mei( ; Yuan, Chun-Mao( ; Hao, Xiao-Jiang(
Source PublicationPHYTOCHEMISTRY
AbstractNine undescribed compounds, including five xanthone derivatives, two flavonoids, one 2-pyrone derivative, and one undescribed naturally occurring compound, along with 30 known phenolic compounds, were isolated from Hypericum japonicum. In addition, hyperjaponols A and B were identified as racemates. The structures and absolute configurations of the undescribed compounds were determined by comprehensive MS, NMR spectroscopy, and electronic circular dichroism (ECD) calculations. The cytotoxic effects of the isolated compounds on two human tumour cell lines (HEL and MDA-MB-231) were evaluated by the MTT assay. Eighteen compounds showed good inhibitory activities against the HEL cell line, with IC50 values of 3.53-18.7 mu M, while nine compounds exhibited moderate cytotoxicity against the MDA-MB-231 cancer cell line, with IC50 values ranging from 4.92 to 10.75 mu M. Their preliminary structure-activity relationship of the isolated compounds was also discussed.
KeywordHypericum japonicum thunb. (Hypericaceae) Phenolic compounds Xanthone and flavonoid derivatives Cytotoxic activities Structure-activity relationship
Indexed BySCI
WOS IDWOS:000475996800004
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Document Type期刊论文
Corresponding AuthorLi, Yan-Mei; Yuan, Chun-Mao; Hao, Xiao-Jiang
Affiliation1.Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550014, Guizhou, Peoples R China
2.Guizhou Med Univ, Sch Pharmaceut Sci, Guiyang 550025, Guizhou, Peoples R China
3.Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550014, Guizhou, Peoples R China
4.Chinese Acad Sci, Guiyang 550014, Guizhou, Peoples R China
5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Zhu, Wei,Qiu, Jie,Zeng, Yan-Rong,et al. Cytotoxic phenolic constituents from Hypericum japonicum[J]. PHYTOCHEMISTRY,2019,164:33-40.
APA Zhu, Wei.,Qiu, Jie.,Zeng, Yan-Rong.,Yi, Ping.,Lou, Hua-Yong.,...&Hao, Xiao-Jiang.(2019).Cytotoxic phenolic constituents from Hypericum japonicum.PHYTOCHEMISTRY,164,33-40.
MLA Zhu, Wei,et al."Cytotoxic phenolic constituents from Hypericum japonicum".PHYTOCHEMISTRY 164(2019):33-40.
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