| Cytotoxic phenolic constituents from Hypericum japonicum | |
Zhu, Wei1,2,3,4; Qiu, Jie1,2,3,4; Zeng, Yan-Rong1,3,4; Yi, Ping1,2,3,4; Lou, Hua-Yong1,3,4; Jian, Jun-You1,2,3,4; Zuo, Ming-Xing1,2,3,4; Duan, Lian1,2,3,4; Gu, Wei1,2,3,4 ; Huang, Lie-Jun1,2,3,4; Li, Yan-Mei1,2,3,4; Yuan, Chun-Mao1,2,3,4; Hao, Xiao-Jiang1,2,3,4,5
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| Corresponding Author | Li, Yan-Mei(liyanmei518@hotmail.com) ; Yuan, Chun-Mao(yuanchunmao01@126.com) ; Hao, Xiao-Jiang(haoxj@mail.kib.ac.cn) |
| 2019-08-01 | |
| Source Publication | PHYTOCHEMISTRY
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| ISSN | 0031-9422 |
| Volume | 164Pages:33-40 |
| Abstract | Nine undescribed compounds, including five xanthone derivatives, two flavonoids, one 2-pyrone derivative, and one undescribed naturally occurring compound, along with 30 known phenolic compounds, were isolated from Hypericum japonicum. In addition, hyperjaponols A and B were identified as racemates. The structures and absolute configurations of the undescribed compounds were determined by comprehensive MS, NMR spectroscopy, and electronic circular dichroism (ECD) calculations. The cytotoxic effects of the isolated compounds on two human tumour cell lines (HEL and MDA-MB-231) were evaluated by the MTT assay. Eighteen compounds showed good inhibitory activities against the HEL cell line, with IC50 values of 3.53-18.7 mu M, while nine compounds exhibited moderate cytotoxicity against the MDA-MB-231 cancer cell line, with IC50 values ranging from 4.92 to 10.75 mu M. Their preliminary structure-activity relationship of the isolated compounds was also discussed. |
| Keyword | Hypericum japonicum thunb. (Hypericaceae) Phenolic compounds Xanthone and flavonoid derivatives Cytotoxic activities Structure-activity relationship |
| DOI | 10.1016/j.phytochem.2019.04.012 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000475996800004 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/68270 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Corresponding Author | Li, Yan-Mei; Yuan, Chun-Mao; Hao, Xiao-Jiang |
| Affiliation | 1.Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550014, Guizhou, Peoples R China 2.Guizhou Med Univ, Sch Pharmaceut Sci, Guiyang 550025, Guizhou, Peoples R China 3.Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550014, Guizhou, Peoples R China 4.Chinese Acad Sci, Guiyang 550014, Guizhou, Peoples R China 5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China |
| Recommended Citation GB/T 7714 | Zhu, Wei,Qiu, Jie,Zeng, Yan-Rong,et al. Cytotoxic phenolic constituents from Hypericum japonicum[J]. PHYTOCHEMISTRY,2019,164:33-40. |
| APA | Zhu, Wei.,Qiu, Jie.,Zeng, Yan-Rong.,Yi, Ping.,Lou, Hua-Yong.,...&Hao, Xiao-Jiang.(2019).Cytotoxic phenolic constituents from Hypericum japonicum.PHYTOCHEMISTRY,164,33-40. |
| MLA | Zhu, Wei,et al."Cytotoxic phenolic constituents from Hypericum japonicum".PHYTOCHEMISTRY 164(2019):33-40. |
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| Zhu-2019-Cytotoxic p（902KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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