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B591, a novel specific pan-PI3K inhibitor, preferentially targets cancer stem cells 期刊论文
ONCOGENE, 2019, 卷号: 38, 期号: 18, 页码: 3371-3386
作者:  Zhou, Hongyu;  Yu, Chunlei;  Kong, Lingmei;  Xu, Xiaoliang;  Yan, Juming;  Li, Yingchao;  An, Tao;  Gong, Liang;  Gong, Yaxiao;  Zhu, Huifang;  Zhang, Hongbin;  Yang, Xiaodong;  Li, Yan
浏览  |  Adobe PDF(5225Kb)  |  收藏  |  浏览/下载:237/27  |  提交时间:2019/06/24
USP7 inhibitor P5091 inhibits Wnt signaling and colorectal tumor growth 期刊论文
BIOCHEMICAL PHARMACOLOGY, 2017, 卷号: 131, 期号: 1, 页码: 29-39
作者:  An, Tao;  Gong, Yaxiao;  Li, Xue;  Kong, Lingmei;  Ma, Pengcheng;  Gong, Liang;  Zhu, Huifang;  Yu, Chunlei;  Liu, Jianmei;  Zhou, Hongyu;  Mao, Bingyu;  Li, Yan
浏览  |  Adobe PDF(3138Kb)  |  收藏  |  浏览/下载:787/145  |  提交时间:2017/04/06
Usp7 Inhibitor  Wnt Signaling  Colorectal Cancer  
Star-PAP, a poly(A) polymerase, functions as a tumor suppressor in an orthotopic human breast cancer model 期刊论文
CELL DEATH & DISEASE, 2017, 卷号: 8, 期号: 1, 页码: e2582
作者:  Yu, C.;  Gong, Y.;  Zhou, H.;  Wang, M.;  Kong, L.;  Liu, J.;  An, T.;  Zhu, H.;  Li, Y.
浏览  |  Adobe PDF(3022Kb)  |  收藏  |  浏览/下载:192/39  |  提交时间:2017/04/19
Absolute Configuration Determination of One New Compound Trichoderol A from Trichoderma sp Fungus 期刊论文
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 2016, 卷号: 37, 期号: 11, 页码: 1972-1976
作者:  Xu Lanlan;  Zhao Qiqi;  Yu He;  Wang Jingchen;  Wang Huijun;  Yang Qin;  Zhu Huajie;  Li Yan
浏览  |  Adobe PDF(1482Kb)  |  收藏  |  浏览/下载:282/42  |  提交时间:2017/02/14
Trichoderma Sp.  Electronic Circular Dichroism  Optical Rotation  Matrix  Antibacterial Activity  
Pepluane and Paraliane Diterpenoids from Euphorbia peplus with Potential Anti-inflammatory Activity 期刊论文
JOURNAL OF NATURAL PRODUCTS, 2016, 卷号: 79, 期号: 6, 页码: 1628-1634
作者:  Wan, Luo-Sheng;  Chu, Rui;  Peng, Xing-Rong;  Zhu, Guo-Lei;  Yu, Mu-Yuan;  Li, Lei;  Zhou, Lin;  Lu, Shuang-Yang;  Dong, Jin-Run;  Zhang, Zhi-Run;  Li, Yan;  Qiu, Ming-Hua
浏览  |  Adobe PDF(1360Kb)  |  收藏  |  浏览/下载:275/81  |  提交时间:2016/08/22
Pestalotiopsin C, stereochemistry of a new caryophyllene from a fungus of Trichoderma sp and its tautomerization characteristics in solution 期刊论文
TETRAHEDRON, 2015, 卷号: 71, 期号: 21, 页码: 3491-3494
作者:  Yu, He;  Li, Wen-Xin;  Wang, Jing-Chen;  Yang, Qin;  Wang, Hui-Jun;  Zhang, Can-Can;  Ding, Shuang-Shuang;  Li, Yan;  Zhu, Hua-Jie;  Zhu,HJ (reprint author),Hebei Univ,Coll Pharm,Chinese Ctr Chiral,Key Lab Med Chem & Mol Diagnost,Minist Educ,Baoding 071002,Hebei,Peoples R China.;  hjzhu@mail.kib.ac.cn
浏览  |  Adobe PDF(627Kb)  |  收藏  |  浏览/下载:317/159  |  提交时间:2015/07/20
Pestalotiopsin c  Trichoderma Sp  Optical Rotation  Ecd  Transition State  
Dual-Functional abeo-Taxane Derivatives Destabilizing Microtubule Equilibrium and Inhibiting NF-kappa B Activation 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2013, 卷号: 56, 期号: 11, 页码: 4749-4757
作者:  Zhao, Yu;  Su, Jia;  Goto, Masuo;  Morris-Natschke, Susan L.;  Li, Yan;  Zhao, Qin-Shi;  Yao, Zhu-Jun;  Lee, Kuo-Hsiung
浏览  |  Adobe PDF(531Kb)  |  收藏  |  浏览/下载:311/65  |  提交时间:2013/10/16
Natural-products  Biological-activity  Cancer-therapy  Paclitaxel  Taxol  Resistance  Drugs  Chemotherapy  Parthenolide  Brevifoliol  
Psychotripine: A New Trimeric Pyrroloindoline Derivative from Psychotria pilifera 期刊论文
ORGANIC LETTERS, 2011, 卷号: 13, 期号: 21, 页码: 5896-5899
作者:  Li, Xiao-Ning;  Zhang, Yu;  Cai, Xiang-Hai;  Feng, Tao;  Liu, Ya-Ping;  Li, Yan;  Ren, Jie;  Zhu, Hua-Jie;  Luo, Xiao-Dong
Adobe PDF(1174Kb)  |  收藏  |  浏览/下载:317/83  |  提交时间:2012/04/10
Monoterpenoid Indole Alkaloids  Electronic Circular-dichroism  Absolute-configuration  Pyrrolidinoindoline Alkaloids  Melodinus-tenuicaudatus  Optical-rotation  Oleoides  Rostrata  
Development of novel conformation-constrained cytotoxic derivatives of cheliensisin A by embedment of small heterocycles 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2011, 卷号: 46, 期号: 9, 页码: 4238-4244
作者:  Deng, Xu;  Su, Jia;  Zhao, Yu;  Peng, Li-Yan;  Li, Yan;  Yao, Zhu-Jun;  Zhao, Qin-Shi
Adobe PDF(450Kb)  |  收藏  |  浏览/下载:389/97  |  提交时间:2012/03/16
Cheliensisin a  Derivative  Structure-activity Relationship  Cytotoxicity  Anticancer  
Fragmentations of 13-oxo-taxyunnansin A and their application to preparation of abeo-paclitaxel and abeo-docetaxel analogues 期刊论文
TETRAHEDRON LETTERS, 2011, 卷号: 52, 期号: 1, 页码: 139-142
作者:  Zhao, Yu;  Zhang, Hong-Bin;  Liu, Ji-Kai;  Su, Jia;  Li, Yan;  Yao, Zhu-Jun;  Zhao, Qin-Shi
Adobe PDF(602Kb)  |  收藏  |  浏览/下载:344/113  |  提交时间:2012/04/10
Taxyunnansin a  Abeo-taxoids  Fragmentation  Abeo-paclitaxel  Anticancer