Star-PAP, a poly(A) polymerase, functions as a tumor suppressor in an orthotopic human breast cancer model

doi:10.1038/cddis.2016.199

	Star-PAP, a poly(A) polymerase, functions as a tumor suppressor in an orthotopic human breast cancer model
	Yu, C.1,2; Gong, Y.1,2; Zhou, H.1; Wang, M.1,2; Kong, L.1; Liu, J.1 ; An, T.1,2 ; Zhu, H.1,2 ; Li, Y.1
	2017-02-01
发表期刊	CELL DEATH & DISEASE
卷号	8 期号:1 页码:e2582
摘要	Star-PAP is a noncanonical poly(A) polymerase and required for the expression of a select set of mRNAs. However, the pathological role of Star-PAP in cancer largely remains unknown. In this study, we observed decreased expression of Star-PAP in breast cancer cell lines and tissues. Ectopic Star-PAP expression inhibited proliferation as well as colony-forming ability of breast cancer cells. In breast cancer patients, high levels of Star-PAP correlated with an improved prognosis. Moreover, by regulating the expression of BIK (BCL2-interacting killer), Star-PAP induced apoptosis of breast cancer cells through the mitochondrial pathway. The growth of breast cancer xenografts in NOD/SCID mice was also inhibited by the doxycycline-induced Star-PAP overexpression. Furthermore, Star-PAP sensitized breast cancer cells to chemotherapy drugs both in vitro and in vivo. In mammary epithelial cells, Star-PAP knockdown partially transformed these cells and induced them to undergo epithelial-mesenchymal transition (EMT). These findings suggested that Star-PAP possesses tumor-suppressing activity and can be a valuable target for developing new cancer therapeutic strategies.
DOI	10.1038/cddis.2016.199
收录类别	SCI
语种	英语
WOS记录号	WOS:000393680700025
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/46030
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Yu, C.,Gong, Y.,Zhou, H.,et al. Star-PAP, a poly(A) polymerase, functions as a tumor suppressor in an orthotopic human breast cancer model[J]. CELL DEATH & DISEASE,2017,8(1):e2582.
APA	Yu, C..,Gong, Y..,Zhou, H..,Wang, M..,Kong, L..,...&Li, Y..(2017).Star-PAP, a poly(A) polymerase, functions as a tumor suppressor in an orthotopic human breast cancer model.CELL DEATH & DISEASE,8(1),e2582.
MLA	Yu, C.,et al."Star-PAP, a poly(A) polymerase, functions as a tumor suppressor in an orthotopic human breast cancer model".CELL DEATH & DISEASE 8.1(2017):e2582.

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