Fragmentations of 13-oxo-taxyunnansin A and their application to preparation of abeo-paclitaxel and abeo-docetaxel analogues

doi:10.1016/j.tetlet.2010.11.008

	Fragmentations of 13-oxo-taxyunnansin A and their application to preparation of abeo-paclitaxel and abeo-docetaxel analogues
	Zhao, Yu 2; Zhang, Hong-Bin 3; Liu, Ji-Kai 2; Su, Jia 2; Li, Yan2 ; Yao, Zhu-Jun 1; Zhao, Qin-Shi2
通讯作者	Yao, ZJ (reprint author), Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, EISU Chem Biol Div, 345 Lingling Lu, Shanghai 200032, Peoples R China
	2011-01-05
发表期刊	TETRAHEDRON LETTERS
ISSN	0040-4039
卷号	52 期号:1 页码:139-142
摘要	Two interesting unprecedented fragmentations of 13-oxo-taxyunnansin A (3), initiated by treatment with (t)BuOK and Red-Al, respectively, have been discovered, optimized and successfully applied to the synthesis of novel abeo-paclitaxel and abeo-docetaxel derivatives. Eight new derivatives of abeo-paclitaxel and abeo-docetaxel possessing the structurally simplified 11 (15 -> 1)-abeo-taxane skeleton with an oxetane ring and pi bond conjugate system were accordingly prepared for the further evaluation of anticancer activities. (C) 2010 Elsevier Ltd. All rights reserved.
关键词	Taxyunnansin a Abeo-taxoids Fragmentation Abeo-paclitaxel Anticancer
学科领域	Chemistry
DOI	10.1016/j.tetlet.2010.11.008
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000286789100034
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/5559
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, EISU Chem Biol Div, Shanghai 200032, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 3.Yunnan Univ, Sch Chem Sci & Technol, Kunming 650091, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Yu,Zhang, Hong-Bin,Liu, Ji-Kai,et al. Fragmentations of 13-oxo-taxyunnansin A and their application to preparation of abeo-paclitaxel and abeo-docetaxel analogues[J]. TETRAHEDRON LETTERS,2011,52(1):139-142.
APA	Zhao, Yu.,Zhang, Hong-Bin.,Liu, Ji-Kai.,Su, Jia.,Li, Yan.,...&Zhao, Qin-Shi.(2011).Fragmentations of 13-oxo-taxyunnansin A and their application to preparation of abeo-paclitaxel and abeo-docetaxel analogues.TETRAHEDRON LETTERS,52(1),139-142.
MLA	Zhao, Yu,et al."Fragmentations of 13-oxo-taxyunnansin A and their application to preparation of abeo-paclitaxel and abeo-docetaxel analogues".TETRAHEDRON LETTERS 52.1(2011):139-142.

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