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题名: Fragmentations of 13-oxo-taxyunnansin A and their application to preparation of abeo-paclitaxel and abeo-docetaxel analogues
作者: Zhao, Yu2; Zhang, Hong-Bin3; Liu, Ji-Kai2; Su, Jia2; null(李艳)2; Yao, Zhu-Jun1; null(赵勤实)2
刊名: TETRAHEDRON LETTERS
关键词: Taxyunnansin A ; abeo-Taxoids ; Fragmentation ; abeo-Paclitaxel ; Anticancer
英文摘要: Two interesting unprecedented fragmentations of 13-oxo-taxyunnansin A (3), initiated by treatment with (t)BuOK and Red-Al, respectively, have been discovered, optimized and successfully applied to the synthesis of novel abeo-paclitaxel and abeo-docetaxel derivatives. Eight new derivatives of abeo-paclitaxel and abeo-docetaxel possessing the structurally simplified 11 (15 -> 1)-abeo-taxane skeleton with an oxetane ring and pi bond conjugate system were accordingly prepared for the further evaluation of anticancer activities. (C) 2010 Elsevier Ltd. All rights reserved.
出版日期: 2011-01-05
卷号: 52, 期号:1, 页码:139-142
DOI标识: 10.1016/j.tetlet.2010.11.008
语种: 英语
收录类别: SCI ; IC
学科分类: Chemistry
ISSN号: 0040-4039
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/5559
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, EISU Chem Biol Div, Shanghai 200032, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
3.Yunnan Univ, Sch Chem Sci & Technol, Kunming 650091, Peoples R China

Recommended Citation:
Zhao, Y; Zhang, HB; Liu, JK; Su, J; Li, Y; Yao, ZJ; Zhao, QS.Fragmentations of 13-oxo-taxyunnansin A and their application to preparation of abeo-paclitaxel and abeo-docetaxel analogues,TETRAHEDRON LETTERS,2011,52(1):139-142
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