Fragmentations of 13-oxo-taxyunnansin A and their application to preparation of abeo-paclitaxel and abeo-docetaxel analogues
Zhao, Yu2; Zhang, Hong-Bin3; Liu, Ji-Kai2; Su, Jia2; Li, Yan2; Yao, Zhu-Jun1; Zhao, Qin-Shi2
2011-01-05
发表期刊TETRAHEDRON LETTERS
ISSN0040-4039
卷号52期号:1页码:139-142
摘要Two interesting unprecedented fragmentations of 13-oxo-taxyunnansin A (3), initiated by treatment with (t)BuOK and Red-Al, respectively, have been discovered, optimized and successfully applied to the synthesis of novel abeo-paclitaxel and abeo-docetaxel derivatives. Eight new derivatives of abeo-paclitaxel and abeo-docetaxel possessing the structurally simplified 11 (15 -> 1)-abeo-taxane skeleton with an oxetane ring and pi bond conjugate system were accordingly prepared for the further evaluation of anticancer activities. (C) 2010 Elsevier Ltd. All rights reserved.
关键词Taxyunnansin a Abeo-taxoids Fragmentation Abeo-paclitaxel Anticancer
资助信息National Natural Science Foundation of China[20802083, 90813004, 20921091, 21032002]; West Doctor Foundation of CAS[2908026212W1]; Ministry of Science and Technology[2009CB522303, 2010CB833200]; MOH[2009ZX09501]
学科领域Chemistry
DOI10.1016/j.tetlet.2010.11.008
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000286789100034
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/5559
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, EISU Chem Biol Div, Shanghai 200032, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
3.Yunnan Univ, Sch Chem Sci & Technol, Kunming 650091, Peoples R China
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GB/T 7714
Zhao, Yu,Zhang, Hong-Bin,Liu, Ji-Kai,et al. Fragmentations of 13-oxo-taxyunnansin A and their application to preparation of abeo-paclitaxel and abeo-docetaxel analogues[J]. TETRAHEDRON LETTERS,2011,52(1):139-142.
APA Zhao, Yu.,Zhang, Hong-Bin.,Liu, Ji-Kai.,Su, Jia.,Li, Yan.,...&Zhao, Qin-Shi.(2011).Fragmentations of 13-oxo-taxyunnansin A and their application to preparation of abeo-paclitaxel and abeo-docetaxel analogues.TETRAHEDRON LETTERS,52(1),139-142.
MLA Zhao, Yu,et al."Fragmentations of 13-oxo-taxyunnansin A and their application to preparation of abeo-paclitaxel and abeo-docetaxel analogues".TETRAHEDRON LETTERS 52.1(2011):139-142.
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