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Oligosaccharide Blocks PAR1 (Proteinase-Activated Receptor 1)-PAR4-Mediated Platelet Activation by Binding to Thrombin Exosite II and Impairs Thrombosis 期刊论文
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2023, 卷号: 43, 期号: 2, 页码: 253-266
作者:  Li,Sujuan;  Wang,Weili;  Lin,Lisha;  Yang,Lian;  Cai,Ying;  Yang,Xingzhi;  Zhang,Taocui;  Xiao,Chuang;  Yan,Hui;  Gao,Na;  Zhao,Jinhua
Adobe PDF(2610Kb)  |  收藏  |  浏览/下载：5/1  |  提交时间：2024/05/09
oligosaccharide  platelet activation  receptor  protease-activated  thrombin thrombosis  ANTIPLATELET THERAPIES  ALLOSTERIC LINKAGE  TISSUE FACTOR  PROTEASE  VORAPAXAR  MECHANISM  REVEALS  SITE  
Structural characterization of oligosaccharides from free radical depolymerized fucosylated glycosaminoglycan and suggested mechanism of depolymerization 期刊论文
CARBOHYDRATE POLYMERS, 2021, 卷号: 270, 页码: 118368
作者:  Chen,Ru;  Yin,Ronghua;  Li,Shanni;  Pan,Ying;  Mao,Hui;  Cai,Ying;  Lin,Lisha;  Wang,Weili;  Zhang,Taocui;  Zhou,Lutan;  Gao,Na;  Luo,Xiaodong;  Zhao,Jinhua
浏览  |  Adobe PDF(3356Kb)  |  收藏  |  浏览/下载：88/22  |  提交时间：2022/04/02
Fucosylated glycosaminoglycan  Free radical depolymerization  Chemical structure  Oligosaccharide  NMR  INTRINSIC TENASE COMPLEX  ANTICOAGULANT ACTIVITIES  SEA-CUCUMBER  CHONDROITIN SULFATE  PHYSICOCHEMICAL CHARACTERISTICS  FACTOR XASE  POLYSACCHARIDES  DERIVATIVES  HEPARIN  
The Toxicology of Native Fucosylated Glycosaminoglycans and the Safety of Their Depolymerized Products as Anticoagulants 期刊论文
MARINE DRUGS, 2021, 卷号: 19, 期号: 9, 页码: 487
作者:  Lin,Lisha;  Li,Sujuan;  Gao,Na;  Wang,Weili;  Zhang,Taocui;  Yang,Lian;  Yang,Xingzhi;  Luo,Dan;  Ji,Xu;  Zhao,Jinhua
浏览  |  Adobe PDF(2854Kb)  |  收藏  |  浏览/下载：79/10  |  提交时间：2022/04/02
fucosylated glycosaminoglycan  anticoagulant  platelet aggregation  contact activation  hypotension  pulmonary embolism  CHONDROITIN SULFATE  CONTACT SYSTEM  COMPLEMENT  COAGULATION  ACTIVATION  ACCUMULATION  INVOLVEMENT  DERIVATIVES  KALLIKREIN  THROMBOSIS  
Pharmacokinetics and Pharmacodynamics of a Depolymerized Glycosaminoglycan from Holothuria fuscopunctata, a Novel Anticoagulant Candidate, in Rats by Bioanalytical Methods 期刊论文
MARINE DRUGS, 2021, 卷号: 19, 期号: 4, 页码: 212
作者:  Liu,Shuang;  Zhang,Taocui;  Sun,Huifang;  Lin,Lisha;  Gao,Na;  Wang,Weili;  Li,Sujuan;  Zhao,Jinhua
浏览  |  Adobe PDF(1230Kb)  |  收藏  |  浏览/下载：150/52  |  提交时间：2022/04/02
pharmacokinetics  pharmacodynamics  anticoagulant  fucosylated glycosaminoglycan  dHG-5  method validation  
Oligosaccharides from fucosylated glycosaminoglycan prevent breast cancer metastasis in mice by inhibiting heparanase activity and angiogenesis 期刊论文
PHARMACOLOGICAL RESEARCH, 2021, 卷号: 166, 页码: 105527
作者:  Zhou,Lutan;  Yin,Ronghua;  Gao,Na;  Sun,Huifang;  Chen,Dingyuan;  Cai,Ying;  Ren,Lin;  Yang,Lian;  Zuo,Zhili;  Zhang,Hongbin;  Zhao,Jinhua
浏览  |  Adobe PDF(8336Kb)  |  收藏  |  浏览/下载：88/11  |  提交时间：2022/04/02
Oligosaccharides  Heparanase  Angiogenesis  Metastasis  FIBROBLAST-GROWTH-FACTOR  TUMOR-GROWTH  SULFATE PROTEOGLYCANS  MAMMALIAN HEPARANASE  COMBINATION  MECHANISMS  DISCOVERY  BINDING  TARGET  PI-88  
Effects of Native Fucosylated Glycosaminoglycan, Its Depolymerized Derivatives on Intrinsic Factor Xase, Coagulation, Thrombosis, and Hemorrhagic Risk 期刊论文
THROMBOSIS AND HAEMOSTASIS, 2020
作者:  Zhou, Lutan;  Gao, Na;  Sun, Huifang;  Xiao, Chuang;  Yang, Lian;  Lin, Lisha;  Yin, Ronghua;  Li, Zi;  Zhang, Hongbin;  Ji, Xu;  Zhao, Jinhua
浏览  |  Adobe PDF(1210Kb)  |  收藏  |  浏览/下载：219/53  |  提交时间：2021/01/05
Characterization of the Hydrolysis Kinetics of Fucosylated Glycosaminoglycan in Mild Acid and Structures of the Resulting Oligosaccharides 期刊论文
MARINE DRUGS, 2020
作者:  Liu, Xixi;  Zhang, Zhexian;  Mao, Hui;  Wang, Pin;  Zuo, Zhichuang;  Gao, Li;  Shi, Xiang;  Yin, Ronghua;  Gao, Na;  Zhao, Jinhua
浏览  |  Adobe PDF(1321Kb)  |  收藏  |  浏览/下载：133/45  |  提交时间：2021/01/05
Structural analysis and anticoagulant activities of three highly regular fucan sulfates as novel intrinsic factor Xase inhibitors 期刊论文
CARBOHYDRATE POLYMERS, 2018, 卷号: 195, 页码: 257-266
作者:  Shang, Feineng;  Mou, Rongrong;  Zhang, Zhidong;  Gao, Na;  Lin, Lisha;  Li, Zhongkun;  Wu, Mingyi;  Zhao, Jinhua
浏览  |  Adobe PDF(2021Kb)  |  收藏  |  浏览/下载：336/62  |  提交时间：2018/07/16
Fucan Sulfate  Chemical Structure  Anticoagulant  Polysaccharide  Sea Cucumber  
糙海参质量标准研究 期刊论文
中国医院药学杂志, 2016, 期号: 14, 页码: 1176-1180
作者:  刘程程;  李姿;  高娜;  吴明一;  王志平;  赵金华;  张庆芝
浏览  |  Adobe PDF(277Kb)  |  收藏  |  浏览/下载：252/79  |  提交时间：2016/12/19
糙海参  质量标准  骨片鉴别  酸性多糖  
Anti-HIV-1 activity and structure-activity-relationship study of a fucosylated glycosaminoglycan from an echinoderm by targeting the conserved CD4 induced epitope 期刊论文
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2013, 卷号: 1830, 期号: 10, 页码: 4681-4691
作者:  Lian, Wu;  Wu, Mingyi;  Huang, Ning;  Gao, Na;  Xiao, Chuang;  Li, Zi;  Zhang, Zhigang;  Zheng, Yongtang;  Peng, Wenlie;  Zhao, Jinhua
Adobe PDF(2650Kb)  |  收藏  |  浏览/下载：472/93  |  提交时间：2013/11/12
Glycosaminoglycan  Anti-human Immunodeficiency Virus Activity  Envelope Glycoprotein 120  Cluster Of Differentiation 4 Induced Epitope  Biolayer Interferometry  Structure-activity Relationship