Structural analysis and anticoagulant activities of three highly regular fucan sulfates as novel intrinsic factor Xase inhibitors
Shang, Feineng1,3; Mou, Rongrong1; Zhang, Zhidong1; Gao, Na1; Lin, Lisha1; Li, Zhongkun2; Wu, Mingyi1; Zhao, Jinhua1
2018-09-01
Source PublicationCARBOHYDRATE POLYMERS
ISSN0144-8617
Volume195Pages:257-266
Abstract

Fucoidan or fucan sulfate, a sulfated polysaccharide from algae or echinoderm mainly containing fucoses, possesses complex chemical structure and various biological activities. Herein, three fucan sulfates consisted of distinctive simplest repeating units were isolated from Holothuria fuscopunctata, Thelenota ananas and Stichopus horrens. The structural sequences of these fucan sulfates from H. fuscopunctata, T. ananas and S. horrens are -> 4-a-L-Fucp-(3SO(3)(-))-1 ->, -> 4-alpha-L-Fucp-(2SO(3)(-))-1 -> and -> 3-alpha-L-Fucp-(2SO(3)(-))-1 ->, respectively, revealing the existence of the highly regular homogeneous fucan sulfates and their structural diversity in the sea cucumber species for the first time. Pharmacological assays indicated their specific sulfation pattern and position of the glycosidic linkage may contribute to the anticoagulant action. Further mechanism analysis suggested that these fucan sulfates may exhibit strong inhibition of the intrinsic coagulation pathway by targeting the intrinsic coagulation factor Xase. Our results provide novel information to enrich knowledge on structural types of fucan sulfate and to illustrate its functionality.

KeywordFucan Sulfate Chemical Structure Anticoagulant Polysaccharide Sea Cucumber
DOI10.1016/j.carbpol.2018.04.117
Language英语
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Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/61365
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Kunming Med Univ, Yanan Hosp, Dept Pharm, Kunming 650051, Yunnan, Peoples R China
3.Dehong Peoples Hosp, Dehong 678400, Peoples R China
Recommended Citation
GB/T 7714
Shang, Feineng,Mou, Rongrong,Zhang, Zhidong,et al. Structural analysis and anticoagulant activities of three highly regular fucan sulfates as novel intrinsic factor Xase inhibitors[J]. CARBOHYDRATE POLYMERS,2018,195:257-266.
APA Shang, Feineng.,Mou, Rongrong.,Zhang, Zhidong.,Gao, Na.,Lin, Lisha.,...&Zhao, Jinhua.(2018).Structural analysis and anticoagulant activities of three highly regular fucan sulfates as novel intrinsic factor Xase inhibitors.CARBOHYDRATE POLYMERS,195,257-266.
MLA Shang, Feineng,et al."Structural analysis and anticoagulant activities of three highly regular fucan sulfates as novel intrinsic factor Xase inhibitors".CARBOHYDRATE POLYMERS 195(2018):257-266.
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