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Nonasaccharide Inhibits Intrinsic Factor Xase Complex by Binding to Factor IXa and Disrupting Factor IXa-Factor VIIIa Interactions 期刊论文
THROMBOSIS AND HAEMOSTASIS, 2019, 卷号: 119, 期号: 5, 页码: 705-715
Authors:  Xiao, Chuang;  Zhao, Longyan;  Gao, Na;  Wu, Mingyi;  Zhao, Jinhua
Favorite  |  View/Download:0/0  |  Submit date:2019/06/24
nonasaccharide from fucosylated glycosaminoglycan  intrinsic factor Xase complex  factor IXa  anticoagulant  
Physicochemical Characteristics and Anticoagulant Activities of the Polysaccharides from Sea Cucumber Pattalus mollis 期刊论文
MARINE DRUGS, 2019, 卷号: 17, 期号: 4, 页码: 15
Authors:  Zheng, Wenqi;  Zhou, Lutan;  Lin, Lisha;  Cai, Ying;  Sun, Huifang;  Zhao, Longyan;  Gao, Na;  Yin, Ronghua;  Zhao, Jinhua
Favorite  |  View/Download:5/0  |  Submit date:2019/06/24
Pattalus mollis  fucosylated glycosaminoglycan  fucan sulfate  physicochemical characteristics  anticoagulant activities  
Precise Structure and Anticoagulant Activity of Fucosylated Glycosaminoglycan from Apostichopus japonicus: Analysis of Its Depolymerized Fragments 期刊论文
MARINE DRUGS, 2019, 卷号: 17, 期号: 4, 页码: 13
Authors:  Guan, Ruowei;  Peng, Yuan;  Zhou, Lutan;  Zheng, Wenqi;  Liu, Xixi;  Wang, Pin;  Yuan, Qingxia;  Gao, Na;  Zhao, Longyan;  Zhao, Jinhua
Favorite  |  View/Download:0/0  |  Submit date:2019/06/24
Apostichopus japonicus  fucosylated glycosaminoglycan  oligosaccharide  unambiguous structure  anti-Fxase  
Synthesis of trisaccharide repeating unit of fucosylated chondroitin sulfate 期刊论文
ORGANIC & BIOMOLECULAR CHEMISTRY, 2019, 卷号: 17, 期号: 11, 页码: 2877-2882
Authors:  He, Haiqing;  Chen, Dong;  Li, Xiaomei;  Li, Chengji;  Zhao, Jin-Hua;  Qin, Hong-Bo
Favorite  |  View/Download:57/0  |  Submit date:2019/04/15
Synthesis of Fucosylated Chondroitin Sulfate Nonasaccharide as a Novel Anticoagulant Targeting Intrinsic Factor Xase Complex 期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2018, 卷号: 57, 期号: 39, 页码: 12880-12885
Authors:  Zhang, Xiao;  Liu, Huiying;  Lin, Lisha;  Yao, Wang;  Zhao, Jinhua;  Wu, Mingyi;  Li, Zhongjun
View  |  Adobe PDF(1568Kb)  |  Favorite  |  View/Download:61/5  |  Submit date:2018/10/22
Anticoagulants  Drug Discovery  Fucosylated Chondroitin Sulfate  Glycosaminoglycans  Oligosaccharides  
Oligosaccharides from depolymerized fucosylated glycosaminoglycan: Structures and minimum size for intrinsic factor Xase complex inhibition 期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 卷号: 293, 期号: 36, 页码: 14089-14099
Authors:  Yin, Ronghua;  Zhou, Lutan;  Gao, Na;  Li, Zi;  Zhao, Longyan;  Shang, Feineng;  Wu, Mingyi;  Zhao, Jinhua
View  |  Adobe PDF(1313Kb)  |  Favorite  |  View/Download:52/3  |  Submit date:2018/10/07
Natural Product  Carbohydrate Chemistry  Carbohydrate Structure  Chemical Modification  Drug Discovery  Oligosaccharide  Thrombosis  
Structural analysis and anticoagulant activities of three highly regular fucan sulfates as novel intrinsic factor Xase inhibitors 期刊论文
CARBOHYDRATE POLYMERS, 2018, 卷号: 195, 页码: 257-266
Authors:  Shang, Feineng;  Mou, Rongrong;  Zhang, Zhidong;  Gao, Na;  Lin, Lisha;  Li, Zhongkun;  Wu, Mingyi;  Zhao, Jinhua
View  |  Adobe PDF(2021Kb)  |  Favorite  |  View/Download:156/6  |  Submit date:2018/07/16
Fucan Sulfate  Chemical Structure  Anticoagulant  Polysaccharide  Sea Cucumber  
An anticoagulant fucan sulfate with hexasaccharide repeating units from the sea cucumber Holothuria albiventer 期刊论文
CARBOHYDRATE RESEARCH, 2018, 卷号: 464, 页码: 12-18
Authors:  Cai, Ying;  Yang, Wenjiao;  Yin, Ronghua;  Zhou, Lutan;  Li, Zhongkun;  Wu, Mingyi;  Zhao, Jinhua
View  |  Adobe PDF(4007Kb)  |  Favorite  |  View/Download:136/2  |  Submit date:2018/07/16
Fucan Sulfate  Chemical Structure  Anticoagulant  Polysaccharide  Sea Cucumber  
Digestibility of fucosylated glycosaminoglycan from sea cucumber and its effects on digestive enzymes under simulated salivary and gastrointestinal conditions 期刊论文
CARBOHYDRATE POLYMERS, 2018, 卷号: 186, 页码: 217-225
Authors:  Zhao, Longyan;  Qin, Yujing;  Guan, Ruowei;  Zheng, Wenqi;  Liu, Jikai;  Zhao, Jinhua
Favorite  |  View/Download:58/0  |  Submit date:2018/05/08
Sea Cucumber  Polysaccharide  Fucosylated Glycosaminoglycan  In Vitro Digestion  Digestive Enzyme  
Precise structures of fucosylated glycosaminoglycan and its oligosaccharides as novel intrinsic factor Xase inhibitors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 148, 页码: 423-435
Authors:  Shang, Feineng;  Gao, Na;  Yin, Ronghua;  Lin, Lisha;  Xiao, Chuang;  Zhou, Lutan;  Li, Zi;  Purcell, Steven W.;  Wu, Mingyi;  Zhao, Jinhua
View  |  Adobe PDF(3117Kb)  |  Favorite  |  View/Download:67/8  |  Submit date:2018/05/08
Glycosaminoglycan  Oligosaccharide  Anticoagulant  Intrinsic Factor Xase