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Celastrol as an intestinal FXR inhibitor triggers tripolide-induced intestinal bleeding: Underlying mechanism of gastrointestinal injury induced by Tripterygium wilfordii 期刊论文
PHYTOMEDICINE, 2023, 卷号: 121, 页码: 155054
作者:  Dai,Manyun;  Peng,Wan;  Lin,Lisha;  Wu,Zhanxuan;  Zhang,Ting;  Zhao,Qi;  Cheng,Yan;  Lin,Qiuxia;  Zhang,Binbin;  Liu,Aiming;  Rao,Qianru;  Huang,Jianfeng;  Zhao,Jinhua;  Gonzalez,Frank J.;  Li,Fei
浏览  |  Adobe PDF(17974Kb)  |  收藏  |  浏览/下载：69/19  |  提交时间：2024/07/17
Intestinal bleeding  Triptolide  Celastrol  Intestinal FXR  Tripterygium wilfordii  FARNESOID-X-RECEPTOR  BACTERIAL TRANSLOCATION  ACTIVATION  INFLAMMATION  DYSFUNCTION  TRIPTOLIDE  MICROBIOTA  PREVENTS  OBESITY  MICE  
Dual roles of fucoidan-GPIbα interaction in thrombosis and hemostasis: implications for drug development targeting GPIbα 期刊论文
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2023, 卷号: 21, 期号: 5, 页码: 1274-1288
作者:  Shen,Chuanbin;  Mackeigan,Daniel T.;  Shoara,Aron A.;  Xu,Runjia;  Bhoria,Preeti;  Karakas,Danielle;  Ma,Wenjing;  Cerenzia,Eric;  Chen,ZiYan;  Hoard,Brock;  Lin,Lisha;  Lei,Xi;  Zhu,Guangheng;  Chen,Pingguo;  Johnson,Philip E.;  Ni,Heyu
浏览  |  Adobe PDF(4055Kb)  |  收藏  |  浏览/下载：46/7  |  提交时间：2024/07/22
fucoidan  glycoprotein Ib  platelet  thrombosis  von Willebrand factor  VON-WILLEBRAND-FACTOR  PLATELET GLYCOPROTEIN IB  MOLECULAR-WEIGHT FUCOIDAN  ARTERIAL THROMBOSIS  IX  AGGREGATION  RECEPTOR  ACTIVATION  FIBRINOGEN  INTEGRIN  
Snail-inspired AFG/GelMA hydrogel accelerates diabetic wound healing via inflammatory cytokines suppression and macrophage polarization 期刊论文
BIOMATERIALS, 2023, 卷号: 299, 页码: 122141
作者:  Zhou,Zhipeng;  Deng,Tuo;  Tao,Maixian;  Lin,Lisha;  Sun,Luyun;  Song,Xuemei;  Gao,Dongxiu;  Li,Jixing;  Wang,Zhongjuan;  Wang,Xingzi;  Li,Jinpeng;  Jiang,Zexiu;  Luo,Lan;  Yang,Lian;  Wu,Mingyi
浏览  |  Adobe PDF(24778Kb)  |  收藏  |  浏览/下载：58/17  |  提交时间：2024/07/22
Diabetic wound healing  Biomimetic hydrogels  Glycosaminoglycan  Inflammation suppression  Macrophage polarization  FOOT ULCERS  HUMAN SKIN  ACTIVATION  MANAGEMENT  RECEPTORS  DRESSINGS  EFFICACY  SAFETY  
Oligosaccharide Blocks PAR1 (Proteinase-Activated Receptor 1)-PAR4-Mediated Platelet Activation by Binding to Thrombin Exosite II and Impairs Thrombosis 期刊论文
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2023, 卷号: 43, 期号: 2, 页码: 253-266
作者:  Li,Sujuan;  Wang,Weili;  Lin,Lisha;  Yang,Lian;  Cai,Ying;  Yang,Xingzhi;  Zhang,Taocui;  Xiao,Chuang;  Yan,Hui;  Gao,Na;  Zhao,Jinhua
浏览  |  Adobe PDF(2610Kb)  |  收藏  |  浏览/下载：85/16  |  提交时间：2024/05/09
oligosaccharide  platelet activation  receptor  protease-activated  thrombin thrombosis  ANTIPLATELET THERAPIES  ALLOSTERIC LINKAGE  TISSUE FACTOR  PROTEASE  VORAPAXAR  MECHANISM  REVEALS  SITE  
岩藻糖化糖胺聚糖 系统给药的毒性作用及其相关的血小板激活作用与机制 学位论文
: 中国科学院大学, 2022
作者:  林丽莎
Adobe PDF(5816Kb)  |  收藏  |  浏览/下载：66/0  |  提交时间：2024/05/14
岩藻糖化糖胺聚糖，毒性机制，血小板聚集，构效关系，血小板受体  Fucosylated glycosaminoglycan, Toxic effect, Platelet aggregation, Structure-activity relationship, Platelet receptor  
Structural characterization and anticoagulant analysis of the novel branched fucosylated glycosaminoglycan from sea cucumber Holothuria nobilis 期刊论文
CARBOHYDRATE POLYMERS, 2021, 卷号: 269, 页码: 118290
作者:  Li,Shanni;  Zhong,Wei;  Pan,Ying;  Lin,Lisha;  Cai,Ying;  Mao,Hui;  Zhang,Taocui;  Li,Sujuan;  Chen,Ru;  Zhou,Lutan;  Wang,Weili;  Cui,Qinghua;  Yin,Ronghua;  Huang,Shengxiong;  Zhao,Jinhua
浏览  |  Adobe PDF(2581Kb)  |  收藏  |  浏览/下载：272/36  |  提交时间：2022/04/02
Disaccharide branch  Fucosylated glycosaminoglycan  Holothuria nobilis  Oligosaccharide  Anticoagulant  INTRINSIC TENASE COMPLEX  CHONDROITIN SULFATE  ACAUDINA-MOLPADIOIDEA  FACTOR XASE  HEPARIN  DEPOLYMERIZATION  OLIGOSACCHARIDES  POLYSACCHARIDES  DERIVATIVES  
Structural characterization of oligosaccharides from free radical depolymerized fucosylated glycosaminoglycan and suggested mechanism of depolymerization 期刊论文
CARBOHYDRATE POLYMERS, 2021, 卷号: 270, 页码: 118368
作者:  Chen,Ru;  Yin,Ronghua;  Li,Shanni;  Pan,Ying;  Mao,Hui;  Cai,Ying;  Lin,Lisha;  Wang,Weili;  Zhang,Taocui;  Zhou,Lutan;  Gao,Na;  Luo,Xiaodong;  Zhao,Jinhua
浏览  |  Adobe PDF(3356Kb)  |  收藏  |  浏览/下载：141/36  |  提交时间：2022/04/02
Fucosylated glycosaminoglycan  Free radical depolymerization  Chemical structure  Oligosaccharide  NMR  INTRINSIC TENASE COMPLEX  ANTICOAGULANT ACTIVITIES  SEA-CUCUMBER  CHONDROITIN SULFATE  PHYSICOCHEMICAL CHARACTERISTICS  FACTOR XASE  POLYSACCHARIDES  DERIVATIVES  HEPARIN  
The Toxicology of Native Fucosylated Glycosaminoglycans and the Safety of Their Depolymerized Products as Anticoagulants 期刊论文
MARINE DRUGS, 2021, 卷号: 19, 期号: 9, 页码: 487
作者:  Lin,Lisha;  Li,Sujuan;  Gao,Na;  Wang,Weili;  Zhang,Taocui;  Yang,Lian;  Yang,Xingzhi;  Luo,Dan;  Ji,Xu;  Zhao,Jinhua
浏览  |  Adobe PDF(2854Kb)  |  收藏  |  浏览/下载：178/31  |  提交时间：2022/04/02
fucosylated glycosaminoglycan  anticoagulant  platelet aggregation  contact activation  hypotension  pulmonary embolism  CHONDROITIN SULFATE  CONTACT SYSTEM  COMPLEMENT  COAGULATION  ACTIVATION  ACCUMULATION  INVOLVEMENT  DERIVATIVES  KALLIKREIN  THROMBOSIS  
Pharmacokinetics and Pharmacodynamics of a Depolymerized Glycosaminoglycan from Holothuria fuscopunctata, a Novel Anticoagulant Candidate, in Rats by Bioanalytical Methods 期刊论文
MARINE DRUGS, 2021, 卷号: 19, 期号: 4, 页码: 212
作者:  Liu,Shuang;  Zhang,Taocui;  Sun,Huifang;  Lin,Lisha;  Gao,Na;  Wang,Weili;  Li,Sujuan;  Zhao,Jinhua
浏览  |  Adobe PDF(1230Kb)  |  收藏  |  浏览/下载：258/61  |  提交时间：2022/04/02
pharmacokinetics  pharmacodynamics  anticoagulant  fucosylated glycosaminoglycan  dHG-5  method validation  
High-molecular-weight fucosylated glycosaminoglycan induces human platelet aggregation depending on alpha(IIb)beta(3) and platelet secretion 期刊论文
PLATELETS, 2021, 卷号: 32, 期号: 7, 页码: 975-983
作者:  Lin,Lisha;  Yang,Lian;  Chen,Jun;  Zhou,Lutan;  Li,Sujuan;  Gao,Na;  Zhao,Jinhua
Adobe PDF(3733Kb)  |  收藏  |  浏览/下载：118/31  |  提交时间：2022/04/02
Aggregation  fucosylated glycosaminoglycan  human platelets  secretion  alpha(IIb beta 3)  DEPOLYMERIZED HOLOTHURIAN GLYCOSAMINOGLYCAN  INTRINSIC TENASE COMPLEX  INTEGRIN ALPHA(IIB)BETA(3)  ACTIVATION  AGGLUTINATION  RECEPTOR  ADP  INHIBITION  GENERATION  MECHANISM