Snail-inspired AFG/GelMA hydrogel accelerates diabetic wound healing via inflammatory cytokines suppression and macrophage polarization

doi:10.1016/j.biomaterials.2023.122141

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	Snail-inspired AFG/GelMA hydrogel accelerates diabetic wound healing via inflammatory cytokines suppression and macrophage polarization
	Zhou,Zhipeng; Deng,Tuo; Tao,Maixian; Lin,Lisha; Sun,Luyun; Song,Xuemei; Gao,Dongxiu; Li,Jixing; Wang,Zhongjuan; Wang,Xingzi; Li,Jinpeng; Jiang,Zexiu; Luo,Lan; Yang,Lian; Wu,Mingyi
	2023
发表期刊	BIOMATERIALS
ISSN	1878-5905
卷号	299 页码:122141
摘要	Diabetic foot ulcers (DFUs) are a severe and rapidly growing diabetic complication, but treating DFUs remains a challenge for the existing therapies are expensive and highly non-responsive. Recently, we discovered that a natural adhesive from snail mucus can promote skin wound healing. Herein, inspired by the finding, we developed a double-network hydrogel biomaterial that composed of snail glycosaminoglycan (AFG) and methacrylated gelatin (GelMA), in which AFG is the main bioactive component of snail mucus and GelMA provides a scaffold mimicking the proteins in snail mucus. The biomimetic hydrogel exhibited strong tissue adhesion, potent anti-inflammatory activity, and excellent biocompatibility. The biodegradable AFG/GelMA hydrogel markedly promoted chronic wound healing in both STZ-induced type 1 diabetic rat and db/db mouse models after a single treatment. Further mechanistic research showed that the hydrogel significantly attenuated inflammation by sequestrating pro-inflammatory cytokines, as well as downregulated their expression by inhibiting NF-kappa B signaling pathway, and it can also promote macrophage polarization to M2 phenotype. Taken together, the bioinspired hydrogel can effectively promote the transition of chronic wounds from inflammation to proliferation stage. These data suggest that the AFG/GelMA hydrogel is a promising therapeutic biomaterial for the treatment of chronic diabetic wounds.
关键词	Diabetic wound healing Biomimetic hydrogels Glycosaminoglycan Inflammation suppression Macrophage polarization FOOT ULCERS HUMAN SKIN ACTIVATION MANAGEMENT RECEPTORS DRESSINGS EFFICACY SAFETY
学科领域	Engineering ; Materials Science
DOI	10.1016/j.biomaterials.2023.122141
收录类别	SCI
WOS记录号	WOS:001007294100001
引用统计	被引频次：67[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75470
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Zhou,Zhipeng,Deng,Tuo,Tao,Maixian,et al. Snail-inspired AFG/GelMA hydrogel accelerates diabetic wound healing via inflammatory cytokines suppression and macrophage polarization[J]. BIOMATERIALS,2023,299:122141.
APA	Zhou,Zhipeng.,Deng,Tuo.,Tao,Maixian.,Lin,Lisha.,Sun,Luyun.,...&Wu,Mingyi.(2023).Snail-inspired AFG/GelMA hydrogel accelerates diabetic wound healing via inflammatory cytokines suppression and macrophage polarization.BIOMATERIALS,299,122141.
MLA	Zhou,Zhipeng,et al."Snail-inspired AFG/GelMA hydrogel accelerates diabetic wound healing via inflammatory cytokines suppression and macrophage polarization".BIOMATERIALS 299(2023):122141.

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