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Synthesis and PDE-10 Inhibition of 3-substituted Phenylimino-indolin-2-ones 期刊论文
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2020, 卷号: 126, 页码: 34-34
作者:  Wu, Ya;  Lin, Zhiwei;  Bai, Yun;  Zhang, Yu;  Cai, Qing;  Mu, Shuzhen;  Han, Weiwei;  Hao, Xiaojiang;  Chen, Gang
收藏  |  浏览/下载：191/0  |  提交时间：2020/03/24
Design, synthesis and structure-activity relationship optimization of phenanthridine derivatives as new Wnt/beta-catenin signalling pathway agonists 期刊论文
BIOORGANIC CHEMISTRY, 2019, 卷号: 84, 页码: 285-294
作者:  Chen, Duo-zhi;  Yang, Bi-juan;  He, Xiao-li;  Fan, Shi-rui;  Cai, Jie-yun;  Jing, Chen-xu;  Zhang, Heng;  Zhang, Yu;  Li, Lin;  Hao, Xiao-jiang
浏览  |  Adobe PDF(3047Kb)  |  收藏  |  浏览/下载：331/41  |  提交时间：2019/03/18
Wnt/beta-catenin signalling pathway agonist  Phenanthridine derivatives  Structural optimization  Structure-activity relationships (SARs)  
Efficient synthesis of new phenanthridine Wnt/beta-catenin signaling pathway agonists 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 157, 页码: 1491-1499
作者:  Chen, Duozhi;  Zhang, Heng;  Jing, Chenxu;  He, Xiaoli;  Yang, Bijuan;  Cai, Jieyun;  Zhou, Yunfu;  Song, Xiaoming;  Li, Lin;  Hao, Xiaojiang
收藏  |  浏览/下载：372/0  |  提交时间：2018/11/12
Wnt/beta-catenin signaling agonist  Phenanthridine derivatives  Structural optimization  
The plant sesquiterpene lactone parthenolide inhibits Wnt/-catenin signaling by blocking synthesis of the transcriptional regulators TCF4/LEF1 期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 卷号: 293, 期号: 14, 页码: 5335-5344
作者:  Zhu, Xiaoliang;  Yuan, Chunmao;  Tian, Chenyang;  Li, Chen;  Nie, Fen;  Song, Xiaomin;  Zeng, Rong;  Wu, Dianqing;  Hao, Xiaojiang;  Li, Lin
收藏  |  浏览/下载：420/0  |  提交时间：2018/05/08
Inhibitor  Protein Synthesis  Small Molecule  T-cell Factor (Tcf)  Wnt Signaling  
Efficient synthesis of new phenanthridine Wnt/b-catenin signaling pathway agonists 期刊论文
European Journal of Medicinal Chemistry, 2018, 卷号: 157, 页码: 1491-1499
作者:  Duozhi Chen;  Heng Zhang;  Chenxu Jing;  Xiaoli He;  Bijuan Yang;  Jieyun Cai;  Yunfu Zhou;  Xiaoming Song;  Lin Li;  Xiaojiang Hao
浏览  |  Adobe PDF(1966Kb)  |  收藏  |  浏览/下载：223/86  |  提交时间：2019/03/27
Two novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A 期刊论文
SCIENTIFIC REPORTS, 2017, 卷号: 7, 页码: 1
作者:  Yuan, Wen-Juan;  Ding, Xiao;  Wang, Zhe;  Yang, Bi-Juan;  Li, Xiao-Nian;  Zhang, Yu;  Chen, Duo-Zhi;  Li, Shun-Lin;  Chen, Quan;  Di, Ying-Tong;  Aisa, Haji Akber;  Hao, Xiao-Jiang
浏览  |  Adobe PDF(3375Kb)  |  收藏  |  浏览/下载：294/56  |  提交时间：2017/12/18
Acylphloroglucinol derivatives from the twigs and leaves of Callistemon salignus 期刊论文
TETRAHEDRON, 2017, 卷号: 73, 期号: 14, 页码: 1803-1811
作者:  Qin, Xu-Jie;  Liu, Hui;  Yu, Qian;  Yan, Huan;  Tang, Jin-Feng;  An, Lin-Kun;  Khan, Afsar;  Chen, Qi-Run;  Hao, Xiao-Jiang;  Liu, Hai-Yang
浏览  |  Adobe PDF(1199Kb)  |  收藏  |  浏览/下载：236/72  |  提交时间：2017/06/01
Callistemon Salignus  Acylphloroglucinol  Aeroterpenoid  Antimicrobial Activity  Cytotoxicity  
Chemical biology reveals CARF as a positive regulator of canonical Wnt signaling by promoting TCF/beta-catenin transcriptional activity 期刊论文
CELL DISCOVERY, 2017, 卷号: 3, 页码: 17003
作者:  He, Xiaoli;  Zhang, Wenjuan;  Yan, Chen;  Nie, Fen;  Li, Chen;  Liu, Xiaofen;  Fei, Cong;  Li, Shengdi;  Song, Xiaomin;  Jia, Yingying;  Zeng, Rong;  Wu, Dianqing;  Pan, Weijun;  Hao, Xiaojiang;  Li, Lin
浏览  |  Adobe PDF(3775Kb)  |  收藏  |  浏览/下载：156/38  |  提交时间：2017/12/18
Carf  Chemical Biology  Nc043  Small Molecule  Wnt Signaling  
(+/-)-Perforison A, A Pair of New Chromone Enantiomers from Harrisonia perforata 期刊论文
NATURAL PRODUCT COMMUNICATIONS, 2017, 卷号: 12, 期号: 1, 页码: 63-65
作者:  Yuan, Wen-Juan;  Gao, Wen-Fen;  Zhang, Jia-Hui;  Cao, Pei;  Zhang, Yu;  Chen, Duo-Zhi;  Li, Shun-Lin;  Di, Ying-Tong;  Hao, Xiao-Jiang
浏览  |  Adobe PDF(954Kb)  |  收藏  |  浏览/下载：439/235  |  提交时间：2017/04/17
Harrisonia Perforata  Simaroubaceae  Chromone  Electronic Circular Dichroism  Perforison a  
Three new diterpenes with cytotoxic activity from the roots of Euphorbia ebracteolata Hayata 期刊论文
PHYTOCHEMISTRY LETTERS, 2016, 卷号: 18, 期号: 1, 页码: 176-179
作者:  Yuan, Wen-Juan;  Yang, Guo-Ping;  Zhang, Jia-Hui;  Zhang, Yu;  Chen, Duo-Zhi;  Li, Shun-Lin;  Di, Ying-Tong;  Hao, Xiao-Jiang
浏览  |  Adobe PDF(558Kb)  |  收藏  |  浏览/下载：509/162  |  提交时间：2017/02/14
Euphorbiaceae  Euphorbia Ebracteolata  Diterpenes  Ebracteolatas A-c  Cytotoxic Activity