Two novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A
Yuan, Wen-Juan1,2,3; Ding, Xiao1; Wang, Zhe1; Yang, Bi-Juan1; Li, Xiao-Nian1; Zhang, Yu1; Chen, Duo-Zhi1; Li, Shun-Lin1; Chen, Quan4; Di, Ying-Tong1; Aisa, Haji Akber2; Hao, Xiao-Jiang1
2017-11-06
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume7Pages:1
AbstractRare ent-abietane-rosane diterpenoid heterodimers, Bisebracteolasins A and B (1 and 2, respectively), were isolated from the roots of Euphorbia ebracteolata Hayata. Their structures and absolute configurations were elucidated from spectroscopic data and X-ray diffraction analysis. Compounds 1 and 2 exhibited moderate cytotoxic effects against five cancer cell lines. Compound 1 showed more effective antiproliferative activities against human tumour cells, HL-60 and SMMC-7721, with IC50 values of 2.61 and 4.08 mu M, respectively, than 2. Both compounds 1 and 2 inhibit the colorectal cancer stem cell line P6C with IC50 values of 16.48 and 34.76 mu M, respectively. Moreover, preliminary biological tests showed compound 1 exhibited inhibitory activity towards tumoursphere formation and migration of the P6C cell line. Overall, we identified two novel diterpenoid heterodimers, and Bisebracteolasin A exhibits therapeutic potential in impeding tumour growth and metastatic ability of cancer stem cells.
DOI10.1038/s41598-017-14637-w
Language英语
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Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/60364
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Xinjiang, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Inst Zool, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100101, Peoples R China
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GB/T 7714
Yuan, Wen-Juan,Ding, Xiao,Wang, Zhe,et al. Two novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A[J]. SCIENTIFIC REPORTS,2017,7:1.
APA Yuan, Wen-Juan.,Ding, Xiao.,Wang, Zhe.,Yang, Bi-Juan.,Li, Xiao-Nian.,...&Hao, Xiao-Jiang.(2017).Two novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A.SCIENTIFIC REPORTS,7,1.
MLA Yuan, Wen-Juan,et al."Two novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A".SCIENTIFIC REPORTS 7(2017):1.
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