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题名: Acylphloroglucinol derivatives from the twigs and leaves of Callistemon salignus
作者: Qin, Xu-Jie1; Liu, Hui1, 2; Yu, Qian3; Yan, Huan1; Tang, Jin-Feng1, 4; An, Lin-Kun3; Khan, Afsar5; Chen, Qi-Run1; Hao, Xiao-Jiang1; null(刘海洋)1
刊名: TETRAHEDRON
关键词: Callistemon salignus ; Acylphloroglucinol ; Aeroterpenoid ; Antimicrobial activity ; Cytotoxicity
英文摘要: Three new acylphloroglucinol derivatives, callisalignones A-C (1-3), six new meroterpenoids, callisalignenes A-F (4-9), along with 18 known analogues (10-27) were isolated from the twigs and leaves of Callistemon salignus. Their structures and absolute configurations were established by comprehensive spectroscopic evidences (NMR, MS, amd electronic circular dichroism calculations). The absolute configurations of callistenones B (13) and H (14) were determined by comparison of their ECD spectra with that of callisalignone B (2). Callisalignones B and C are new adducts of beta-triketone and acylphloroglucinol, whereas callisalignenes A-D are new meroterpenoids of acylphloroglucinol and alpha-phellandrene with different coupling models via hetero-Diels-Alder reaction, respectively. Myrtucommulone D (15) showed significant antibacterial activity against Staphylococcus aureus and three drug resistant S. aureus strains with MIC values of 1.953 and 0.975 mu g/mL, respectively. Isomyrtucommulone B (17) displayed remarkable antibacterial activity against Escherichia coli with an MIC value of 0.122 mu g/mL. Cytotoxic assay revealed that isomyrtucommulone B (17) was the most active against HCT116 with an IC50 value of 2.09 +/- 0.10 mu M. (C) 2017 Elsevier Ltd. All rights reserved.
出版日期: 2017-04-06
卷号: 73, 期号:14, 页码:1803-1811
语种: 英语
收录类别: SCI
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/51050
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Sun Yat Sen Univ, Sch Pharmaceut Sci, Inst Med Chem & Chem Biol, Guangzhou 510006, Guangdong, Peoples R China
4.Guizhou Med Univ, Coll Pharm, Guiyang 550000, Peoples R China
5.COMSATS Inst Informat Technol, Dept Chem, Abbottabad 22060, Pakistan

Recommended Citation:
Qin, Xu-Jie,Liu, Hui,Yu, Qian,et al. Acylphloroglucinol derivatives from the twigs and leaves of Callistemon salignus[J]. TETRAHEDRON,2017,73(14):1803-1811.
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