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Diversity-oriented one-pot multicomponent synthesis of spirooxindole derivatives and their biological evaluation for anticancer activities 期刊论文
TETRAHEDRON, 2016, 卷号: 72, 期号: 52, 页码: 8523-8536
作者:  Yang, Jun;  Liu, Xiong-Wei;  Wang, Dan-Dan;  Tian, Min-Yi;  Han, Shuo-Nan;  Feng, Ting-Ting;  Liu, Xiong-Li;  Mei, Ren-Qiang;  Zhou, Ying
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Five-membered Carbocyclic Spirooxindoles  One-pot Multicomponent Synthesis  Knoevenagel Condensation/michael/cyclization  Aminomethylation  Antitumor Activity  
Eriocalyxin B, a natural diterpenoid, inhibited VEGF-induced angiogenesis and diminished angiogenesis-dependent breast tumor growth by suppressing VEGFR-2 signaling 期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 50, 页码: 82820-82835
作者:  Zhou, Xunian;  Yue, Grace Gar-Lee;  Liu, Minghua;  Zuo, Zhili;  Lee, Julia Kin-Ming;  Li, Mingyue;  Tsui, Stephen Kwok-Wing;  Fung, Kwok-Pui;  Sun, Handong;  Pu, Jianxin;  Lau, Clara Bik-San
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Eriocalyxin b  Angiogenesis  Vascular Endothelial Growth Factor (Vegf)  Vascular Endothelial Growth Factor Receptor 2(Vegfr-2)  Breast Cancer  
16-nor Limonoids from Harrisonia perforata as promising selective 11 beta-HSD1 inhibitors 期刊论文
SCIENTIFIC REPORTS, 2016, 卷号: 6, 页码: 1
作者:  Xiao-HuiYan;  Yi, Ping;  Cao, Pei;  Yang, Shi-Ying;  Fang, Xin;  Zhang, Yu;  Wu, Bin;  Leng, Ying;  Di, Ying-Tong;  Lv, Yang;  Hao, Xiao-Jiang
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Speramides A-B, two new prenylated indole alkaloids from the freshwater-derived fungus Aspergillus ochraceus KM007 期刊论文
TETRAHEDRON LETTERS, 2016, 卷号: 57, 期号: 45, 页码: 4952-4955
作者:  Chang, Yao-Wen;  Yuan, Chun-Mao;  Zhang, Jing;  Liu, Shuai;  Cao, Pei;  Hua, Hui-Ming;  Di, Ying-Tong;  Hao, Xiao-Jiang
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Speramide  Brevianamide  Prenylated Indole Alkaloid  Aspergillus Ochraceus  Notoamide  
New potential beneficial effects of actein, a triterpene glycoside isolated from Cimicifuga species, in breast cancer treatment 期刊论文
SCIENTIFIC REPORTS, 2016, 卷号: 6, 期号: 1, 页码: 1
作者:  Yue, Grace Gar-Lee;  Xie, Sida;  Lee, Julia Kin-Ming;  Kwok, Hin-Fai;  Gao, Si;  Nian, Yin;  Wu, Xiao-Xiao;  Wong, Chun-Kwok;  Qiu, Ming-Hua;  Lau, Clara Bik-San
浏览  |  Adobe PDF(2501Kb)  |  收藏  |  浏览/下载：269/53  |  提交时间：2016/12/21
Cheliensisin A (Chel A) induces apoptosis in human bladder cancer cells by promoting PHLPP2 protein degradation 期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 41, 页码: 66689-66699
作者:  Zhang, Ruowen;  Che, Xun;  Zhang, Jingjie;  Li, Yang;  Li, Jingxia;  Deng, Xu;  Zhu, Junlan;  Jin, Honglei;  Zhao, Qinshi;  Huang, Chuanshu
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Chel a  Human Bladder Cancer  Apoptosis  Phlpp2  C-jun  
Functional Genome Mining for Metabolites Encoded by Large Gene Clusters through Heterologous Expression of a Whole-Genome Bacterial Artificial Chromosome Library in Streptomyces spp. 期刊论文
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2016, 卷号: 82, 期号: 19, 页码: 5795-5805
作者:  Xu, Min;  Wang, Yemin;  Zhao, Zhilong;  Gao, Guixi;  Huang, Sheng-Xiong;  Kang, Qianjin;  He, Xinyi;  Lin, Shuangjun;  Pang, Xiuhua;  Deng, Zixin;  Tao, Meifeng
浏览  |  Adobe PDF(1798Kb)  |  收藏  |  浏览/下载：243/54  |  提交时间：2017/01/05
Synthesis and in vitro evaluation of pyrimidine-fused 3-alkenyloxindoles as potential anticancer agents 期刊论文
TETRAHEDRON LETTERS, 2016, 卷号: 57, 期号: 36, 页码: 4113-4118
作者:  Liu, Xiong-Li;  Feng, Ting-Ting;  Wang, Dan-Dan;  Liu, Huan-Huan;  Yang, Chao;  Li, Xiao-Nian;  Lin, Bing;  Zhao, Zhi;  Zhou, Ying
浏览  |  Adobe PDF(843Kb)  |  收藏  |  浏览/下载：195/50  |  提交时间：2016/11/04
Knoevenagel Condensation  Snar Reaction  Molecular Hybridization  Pyrimidine-fused 3-alkenyloxindoles  Antitumor Activity  
Bioassay-Guided Isolation and Structural Modification of the Anti-TB Resorcinols from Ardisia gigantifolia 期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2016, 卷号: 88, 期号: 2, 页码: 293-301
作者:  Guan, Yi-Fu;  Song, Xun;  Qiu, Ming-Hua;  Luo, Shi-Hong;  Wang, Bao-Jie;  Nguyen Van Hung;  Cuong, Nguyen M.;  Soejarto, Djaja Doel;  Fong, Harry H. S.;  Franzblau, Scott G.;  Li, Sheng-Hong;  He, Zhen-Dan;  Zhang, Hong-Jie
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Ardisia Gigantifolia  Isolation And Structure Identification  Resorcinols  Anti-tb Activity  Mycobacterium Tuberculosis H37rv  Structural Modification  
Bavachinin, as a novel natural pan-PPAR agonist, exhibits unique synergistic effects with synthetic PPAR-gamma and PPAR-alpha agonists on carbohydrate and lipid metabolism in db/db and diet-induced obese mice 期刊论文
DIABETOLOGIA, 2016, 卷号: 59, 期号: 6, 页码: 1276-1286
作者:  Feng, Li;  Luo, Huan;  Xu, Zhijian;  Yang, Zhuo;  Du, Guoxin;  Zhang, Yu;  Yu, Lijing;  Hu, Kaifeng;  Zhu, Weiliang;  Tong, Qingchun;  Chen, Kaixian;  Guo, Fujiang;  Huang, Cheng;  Li, Yiming
浏览  |  Adobe PDF(841Kb)  |  收藏  |  浏览/下载：245/98  |  提交时间：2016/08/22
Alternative Binding Site  Bavachinin  Canonical Ligand-binding Pocket  Carbohydrate Metabolism  Lipid Metabolism  Pan-ppar Agonist  Synergistic Effects