Cheliensisin A (Chel A) induces apoptosis in human bladder cancer cells by promoting PHLPP2 protein degradation
Zhang, Ruowen1; Che, Xun1; Zhang, Jingjie1; Li, Yang1,3; Li, Jingxia1; Deng, Xu2; Zhu, Junlan1,3; Jin, Honglei3; Zhao, Qinshi2; Huang, Chuanshu1
2016-10-11
Source PublicationONCOTARGET
Volume7Issue:41Pages:66689-66699
AbstractCheliensisin A (Chel A), a styryl-lactone compound extracted from Goniothalamus cheliensis, is reported to have significant anti-cancer effects in various cancer cells. Here we demonstrated that Chel A treatment resulted in apoptosis and an inhibition of anchorage-independent growth in human bladder cancer T24, T24T and U5637 cells. Mechanistic studies showed that such effect is mediated by PH domain and Leucine rich repeat Protein Phosphatases (PHLPP2) protein. Chel A treatment led to PHLPP2 degradation and subsequently increased in c-Jun phosphorylation. Moreover PHLPP2 degradation could be attenuated by inhibition of autophagy, which was mediated by Beclin 1. Collectively, we discover that Chel A treatment induces Beclin-dependent autophagy, consequently mediates PHLPP2 degradation and JNK/C-Jun phosphorylation and activation, further in turn contributing to apoptosis in human bladder cancer cells. Current studies provide a significant insight into understanding of anticancer effect of Chel A in treatment of human bladder cancer.
KeywordChel a Human Bladder Cancer Apoptosis Phlpp2 C-jun
DOI10.18632/oncotarget.11440
Indexed BySCI
Language英语
WOS IDWOS:000387446200029
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/33660
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.NYU, Sch Med, Nelson Inst Environm Med, Tuxedo Pk, NY 10987 USA
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
3.Wenzhou Med Univ, Sch Life Sci, Zhejiang Prov Key Lab Technol & Applicat Model Or, Wenzhou 325035, Zhejiang, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Ruowen,Che, Xun,Zhang, Jingjie,et al. Cheliensisin A (Chel A) induces apoptosis in human bladder cancer cells by promoting PHLPP2 protein degradation[J]. ONCOTARGET,2016,7(41):66689-66699.
APA Zhang, Ruowen.,Che, Xun.,Zhang, Jingjie.,Li, Yang.,Li, Jingxia.,...&Huang, Chuanshu.(2016).Cheliensisin A (Chel A) induces apoptosis in human bladder cancer cells by promoting PHLPP2 protein degradation.ONCOTARGET,7(41),66689-66699.
MLA Zhang, Ruowen,et al."Cheliensisin A (Chel A) induces apoptosis in human bladder cancer cells by promoting PHLPP2 protein degradation".ONCOTARGET 7.41(2016):66689-66699.
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