| Cheliensisin A (Chel A) induces apoptosis in human bladder cancer cells by promoting PHLPP2 protein degradation | |
Zhang, Ruowen1; Che, Xun1; Zhang, Jingjie1; Li, Yang1,3; Li, Jingxia1; Deng, Xu2 ; Zhu, Junlan1,3; Jin, Honglei3; Zhao, Qinshi2; Huang, Chuanshu1
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| 2016-10-11 | |
| 发表期刊 | ONCOTARGET
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| 卷号 | 7期号:41页码:66689-66699 |
| 摘要 | Cheliensisin A (Chel A), a styryl-lactone compound extracted from Goniothalamus cheliensis, is reported to have significant anti-cancer effects in various cancer cells. Here we demonstrated that Chel A treatment resulted in apoptosis and an inhibition of anchorage-independent growth in human bladder cancer T24, T24T and U5637 cells. Mechanistic studies showed that such effect is mediated by PH domain and Leucine rich repeat Protein Phosphatases (PHLPP2) protein. Chel A treatment led to PHLPP2 degradation and subsequently increased in c-Jun phosphorylation. Moreover PHLPP2 degradation could be attenuated by inhibition of autophagy, which was mediated by Beclin 1. Collectively, we discover that Chel A treatment induces Beclin-dependent autophagy, consequently mediates PHLPP2 degradation and JNK/C-Jun phosphorylation and activation, further in turn contributing to apoptosis in human bladder cancer cells. Current studies provide a significant insight into understanding of anticancer effect of Chel A in treatment of human bladder cancer. |
| 关键词 | Chel a Human Bladder Cancer Apoptosis Phlpp2 C-jun |
| DOI | 10.18632/oncotarget.11440 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000387446200029 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/33660 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.NYU, Sch Med, Nelson Inst Environm Med, Tuxedo Pk, NY 10987 USA 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China 3.Wenzhou Med Univ, Sch Life Sci, Zhejiang Prov Key Lab Technol & Applicat Model Or, Wenzhou 325035, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Ruowen,Che, Xun,Zhang, Jingjie,et al. Cheliensisin A (Chel A) induces apoptosis in human bladder cancer cells by promoting PHLPP2 protein degradation[J]. ONCOTARGET,2016,7(41):66689-66699. |
| APA | Zhang, Ruowen.,Che, Xun.,Zhang, Jingjie.,Li, Yang.,Li, Jingxia.,...&Huang, Chuanshu.(2016).Cheliensisin A (Chel A) induces apoptosis in human bladder cancer cells by promoting PHLPP2 protein degradation.ONCOTARGET,7(41),66689-66699. |
| MLA | Zhang, Ruowen,et al."Cheliensisin A (Chel A) induces apoptosis in human bladder cancer cells by promoting PHLPP2 protein degradation".ONCOTARGET 7.41(2016):66689-66699. |
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| 11440-173061-4-PB.pd（9106KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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