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New compound ChlA-F induces autophagy-dependent anti-cancer effect via upregulating Sestrin-2 in human bladder cancer 期刊论文
CANCER LETTERS, 2018, 卷号: 436, 页码: 38-51
Authors:  Hua, Xiaohui;  Xua, Jiheng;  Deng, Xu;  Xu, Jiawei;  Li, Jingxia;  Zhu, David Q.;  Zhu, Junlan;  Jin, Honglei;  Tian, Zhongxian;  Huang, Haishan;  Zhao, Qin-shi;  Huang, Chuanshu
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Anchorage-independent growth  Cheliensisine A-fluoride (Ch1A-F)  Macro-autophagy (autophagy)  miR-27a  Sestrin-2  
Cheliensisin A (Chel A) induces apoptosis in human bladder cancer cells by promoting PHLPP2 protein degradation 期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 41, 页码: 66689-66699
Authors:  Zhang, Ruowen;  Che, Xun;  Zhang, Jingjie;  Li, Yang;  Li, Jingxia;  Deng, Xu;  Zhu, Junlan;  Jin, Honglei;  Zhao, Qinshi;  Huang, Chuanshu
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Chel a  Human Bladder Cancer  Apoptosis  Phlpp2  C-jun  
Crucial Role of c-Jun Phosphorylation at Ser63/73 Mediated by PHLPP Protein Degradation in the Cheliensisin A Inhibition of Cell Transformation 期刊论文
CANCER PREVENTION RESEARCH, 2014, 卷号: 7, 期号: 12, 页码: 1270-1281
Authors:  Zhu, Junlan;  Zhang, Jingjie;  Huang, Haishan;  Li, Jingxia;  Yu, Yonghui;  Jin, Honglei;  Li, Yang;  Deng, Xu;  Gao, Jimin;  Zhao, Qinshi;  Huang, Chuanshu;  Huang,CS (reprint author),NYU,Sch Med,Nelson Inst Environm Med,57 Old Forge Rd,Tuxedo Pk,NY 10987 USA.
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Naturally Occurring Substances  Magnetic-resonance Spectroscopy  Stem-bark  Melodinus-henryi  Conformational-analysis  (+)-scholarisine  Mechanism  Leaves  Seeds  Camptothecin  Indole Alkaloids  Cytotoxicity  Absolute Configuration  Vinca Major  
Hydrogen peroxide/ATR-Chk2 activation mediates p53 protein stabilization and anti-cancer activity of cheliensisin A in human cancer cells 期刊论文
ONCOTARGET, 2014, 卷号: 5, 期号: 3, 页码: 841-852
Authors:  Zhang, Jingjie;  Gao, Guangxun;  Chen, Liang;  Li, Jingxia;  Deng, Xu;  Zhao, Qin-shi;  Huang, Chuanshu
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Cheliensisin a  Apoptosis  Colon Cancer  P53  Chemotherapeutic Agent  
Cheliensisin A Inhibits EGF-Induced Cell Transformation with Stabilization of p53 Protein Via a Hydrogen Peroxide/Chk1-Dependent Axis 期刊论文
CANCER PREVENTION RESEARCH, 2013, 卷号: 6, 期号: 9, 页码: 949-958
Authors:  Zhang, Jingjie;  Gao, Guangxun;  Chen, Liang;  Deng, Xu;  Li, Jingxia;  Yu, Yonghui;  Zhang, Dongyun;  Li, Fei;  Zhang, Min;  Zhao, Qinshi;  Huang, Chuanshu
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Dna-damage  Cancer Chemoprevention  Induced Phosphorylation  Activation  Apoptosis  Expression  Induction  Hyperoxia  Therapy  Roles