New potential beneficial effects of actein, a triterpene glycoside isolated from Cimicifuga species, in breast cancer treatment
Yue, Grace Gar-Lee1,2; Xie, Sida3; Lee, Julia Kin-Ming1,2; Kwok, Hin-Fai1,2; Gao, Si1,2; Nian, Yin3; Wu, Xiao-Xiao4; Wong, Chun-Kwok1,2,4; Qiu, Ming-Hua3; Lau, Clara Bik-San1,2
2016-10-12
Source PublicationSCIENTIFIC REPORTS
Volume6Issue:1Pages:1
AbstractActein is a triterpene glycoside isolated from the rhizomes of Cimicifuga foetida (Chinese herb "shengma") which could inhibit the growth of breast cancer cells. Nevertheless, the effect of actein on angiogenesis, which is an essential step for tumor growth and metastasis, has never been reported. Hence, this study aimed to investigate the in vitro and in vivo effects of actein on angiogenesis using human microvascular endothelial cells (HMEC-1), matrigel plug and tumor-bearing mouse models. Our results showed that actein significantly inhibited the proliferation, reduced the migration and motility of endothelial cells, and it could suppress the protein expressions of VEGFR1, pJNK and pERK, suggesting that JNK/ERK pathways were involved. In vivo results showed that oral administration of actein at 10 mg/kg for 7 days inhibited blood vessel formation in the growth factor-containing matrigel plugs. Oral actein treatments (10-15 mg/kg) for 28 days resulted in decreasing mouse 4T1 breast tumor sizes and metastasis to lungs and livers. The apparent reduced angiogenic proteins (CD34 and Factor VIII) expressions and down-regulated metastasis-related VEGFR1 and CXCR4 gene expressions were observed in breast tumors. Our novel findings provide insights into the use of actein for development of anti-angiogenic agents for breast cancer.
DOI10.1038/srep35263
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000385003500001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/33539
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Univ Hong Kong, Inst Chinese Med, Shatin, Hong Kong, Peoples R China
2.Chinese Univ Hong Kong, State Key Lab Phytochem & Plant Resources West Ch, Shatin, Hong Kong, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
4.Chinese Univ Hong Kong, Dept Chem Pathol, Shatin, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Yue, Grace Gar-Lee,Xie, Sida,Lee, Julia Kin-Ming,et al. New potential beneficial effects of actein, a triterpene glycoside isolated from Cimicifuga species, in breast cancer treatment[J]. SCIENTIFIC REPORTS,2016,6(1):1.
APA Yue, Grace Gar-Lee.,Xie, Sida.,Lee, Julia Kin-Ming.,Kwok, Hin-Fai.,Gao, Si.,...&Lau, Clara Bik-San.(2016).New potential beneficial effects of actein, a triterpene glycoside isolated from Cimicifuga species, in breast cancer treatment.SCIENTIFIC REPORTS,6(1),1.
MLA Yue, Grace Gar-Lee,et al."New potential beneficial effects of actein, a triterpene glycoside isolated from Cimicifuga species, in breast cancer treatment".SCIENTIFIC REPORTS 6.1(2016):1.
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