Bavachinin, as a novel natural pan-PPAR agonist, exhibits unique synergistic effects with synthetic PPAR-gamma and PPAR-alpha agonists on carbohydrate and lipid metabolism in db/db and diet-induced obese mice
Feng, Li1,2; Luo, Huan3; Xu, Zhijian4; Yang, Zhuo4; Du, Guoxin1; Zhang, Yu2; Yu, Lijing2; Hu, Kaifeng3; Zhu, Weiliang4; Tong, Qingchun5; Chen, Kaixian1,4; Guo, Fujiang1; Huang, Cheng2; Li, Yiming1
2016-06-01
Source PublicationDIABETOLOGIA
Volume59Issue:6Pages:1276-1286
AbstractAims/hypothesis Pan-peroxisome proliferator-activated receptor (PPAR) agonists have long been sought as therapeutics against the metabolic syndrome, but current PPAR agonists show limited efficacy and adverse effects. Natural herbs provide a structurally untapped resource to prevent and treat complicated metabolic syndrome.
KeywordAlternative Binding Site Bavachinin Canonical Ligand-binding Pocket Carbohydrate Metabolism Lipid Metabolism Pan-ppar Agonist Synergistic Effects
DOI10.1007/s00125-016-3912-9
Indexed BySCI
Language英语
WOS Research AreaEndocrinology & Metabolism
WOS SubjectEndocrinology & Metabolism
WOS IDWOS:000378048500026
Citation statistics
Cited Times:20[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/26290
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Shanghai Univ Tradit Chinese Med, Sch Pharm, Dept TCM Chem, 1200 Cailun Rd, Shanghai 201203, Peoples R China
2.Shanghai Univ Tradit Chinese Med, Lab Drug Discovery, Sch Pharm, 1200 Cailun Rd, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, CAS Key Lab Membrane Res, Shanghai 200031, Peoples R China
5.Univ Texas Hlth Sci Ctr Houston, Inst Mol Med, Brown Fdn, Houston, TX 77030 USA
Recommended Citation
GB/T 7714
Feng, Li,Luo, Huan,Xu, Zhijian,et al. Bavachinin, as a novel natural pan-PPAR agonist, exhibits unique synergistic effects with synthetic PPAR-gamma and PPAR-alpha agonists on carbohydrate and lipid metabolism in db/db and diet-induced obese mice[J]. DIABETOLOGIA,2016,59(6):1276-1286.
APA Feng, Li.,Luo, Huan.,Xu, Zhijian.,Yang, Zhuo.,Du, Guoxin.,...&Li, Yiming.(2016).Bavachinin, as a novel natural pan-PPAR agonist, exhibits unique synergistic effects with synthetic PPAR-gamma and PPAR-alpha agonists on carbohydrate and lipid metabolism in db/db and diet-induced obese mice.DIABETOLOGIA,59(6),1276-1286.
MLA Feng, Li,et al."Bavachinin, as a novel natural pan-PPAR agonist, exhibits unique synergistic effects with synthetic PPAR-gamma and PPAR-alpha agonists on carbohydrate and lipid metabolism in db/db and diet-induced obese mice".DIABETOLOGIA 59.6(2016):1276-1286.
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