Bavachinin, as a novel natural pan-PPAR agonist, exhibits unique synergistic effects with synthetic PPAR-gamma and PPAR-alpha agonists on carbohydrate and lipid metabolism in db/db and diet-induced obese mice

doi:10.1007/s00125-016-3912-9

	Bavachinin, as a novel natural pan-PPAR agonist, exhibits unique synergistic effects with synthetic PPAR-gamma and PPAR-alpha agonists on carbohydrate and lipid metabolism in db/db and diet-induced obese mice
	Feng, Li 1,2; Luo, Huan 3; Xu, Zhijian 4; Yang, Zhuo 4; Du, Guoxin 1; Zhang, Yu2 ; Yu, Lijing 2; Hu, Kaifeng3 ; Zhu, Weiliang 4; Tong, Qingchun 5; Chen, Kaixian 1,4; Guo, Fujiang 1; Huang, Cheng 2; Li, Yiming 1
	2016-06-01
发表期刊	DIABETOLOGIA
卷号	59 期号:6 页码:1276-1286
摘要	Aims/hypothesis Pan-peroxisome proliferator-activated receptor (PPAR) agonists have long been sought as therapeutics against the metabolic syndrome, but current PPAR agonists show limited efficacy and adverse effects. Natural herbs provide a structurally untapped resource to prevent and treat complicated metabolic syndrome.
关键词	Alternative Binding Site Bavachinin Canonical Ligand-binding Pocket Carbohydrate Metabolism Lipid Metabolism Pan-ppar Agonist Synergistic Effects
DOI	10.1007/s00125-016-3912-9
收录类别	SCI
语种	英语
WOS记录号	WOS:000378048500026
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/26290
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Shanghai Univ Tradit Chinese Med, Sch Pharm, Dept TCM Chem, 1200 Cailun Rd, Shanghai 201203, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Lab Drug Discovery, Sch Pharm, 1200 Cailun Rd, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, CAS Key Lab Membrane Res, Shanghai 200031, Peoples R China 5.Univ Texas Hlth Sci Ctr Houston, Inst Mol Med, Brown Fdn, Houston, TX 77030 USA
推荐引用方式 GB/T 7714	Feng, Li,Luo, Huan,Xu, Zhijian,et al. Bavachinin, as a novel natural pan-PPAR agonist, exhibits unique synergistic effects with synthetic PPAR-gamma and PPAR-alpha agonists on carbohydrate and lipid metabolism in db/db and diet-induced obese mice[J]. DIABETOLOGIA,2016,59(6):1276-1286.
APA	Feng, Li.,Luo, Huan.,Xu, Zhijian.,Yang, Zhuo.,Du, Guoxin.,...&Li, Yiming.(2016).Bavachinin, as a novel natural pan-PPAR agonist, exhibits unique synergistic effects with synthetic PPAR-gamma and PPAR-alpha agonists on carbohydrate and lipid metabolism in db/db and diet-induced obese mice.DIABETOLOGIA,59(6),1276-1286.
MLA	Feng, Li,et al."Bavachinin, as a novel natural pan-PPAR agonist, exhibits unique synergistic effects with synthetic PPAR-gamma and PPAR-alpha agonists on carbohydrate and lipid metabolism in db/db and diet-induced obese mice".DIABETOLOGIA 59.6(2016):1276-1286.

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