| Bavachinin, as a novel natural pan-PPAR agonist, exhibits unique synergistic effects with synthetic PPAR-gamma and PPAR-alpha agonists on carbohydrate and lipid metabolism in db/db and diet-induced obese mice | |
Feng, Li1,2; Luo, Huan3; Xu, Zhijian4; Yang, Zhuo4; Du, Guoxin1; Zhang, Yu2 ; Yu, Lijing2; Hu, Kaifeng3; Zhu, Weiliang4; Tong, Qingchun5; Chen, Kaixian1,4; Guo, Fujiang1; Huang, Cheng2; Li, Yiming1
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| 2016-06-01 | |
| Source Publication | DIABETOLOGIA
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| Volume | 59Issue:6Pages:1276-1286 |
| Abstract | Aims/hypothesis Pan-peroxisome proliferator-activated receptor (PPAR) agonists have long been sought as therapeutics against the metabolic syndrome, but current PPAR agonists show limited efficacy and adverse effects. Natural herbs provide a structurally untapped resource to prevent and treat complicated metabolic syndrome. |
| Keyword | Alternative Binding Site Bavachinin Canonical Ligand-binding Pocket Carbohydrate Metabolism Lipid Metabolism Pan-ppar Agonist Synergistic Effects |
| DOI | 10.1007/s00125-016-3912-9 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000378048500026 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/26290 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Affiliation | 1.Shanghai Univ Tradit Chinese Med, Sch Pharm, Dept TCM Chem, 1200 Cailun Rd, Shanghai 201203, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Lab Drug Discovery, Sch Pharm, 1200 Cailun Rd, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, CAS Key Lab Membrane Res, Shanghai 200031, Peoples R China 5.Univ Texas Hlth Sci Ctr Houston, Inst Mol Med, Brown Fdn, Houston, TX 77030 USA |
| Recommended Citation GB/T 7714 | Feng, Li,Luo, Huan,Xu, Zhijian,et al. Bavachinin, as a novel natural pan-PPAR agonist, exhibits unique synergistic effects with synthetic PPAR-gamma and PPAR-alpha agonists on carbohydrate and lipid metabolism in db/db and diet-induced obese mice[J]. DIABETOLOGIA,2016,59(6):1276-1286. |
| APA | Feng, Li.,Luo, Huan.,Xu, Zhijian.,Yang, Zhuo.,Du, Guoxin.,...&Li, Yiming.(2016).Bavachinin, as a novel natural pan-PPAR agonist, exhibits unique synergistic effects with synthetic PPAR-gamma and PPAR-alpha agonists on carbohydrate and lipid metabolism in db/db and diet-induced obese mice.DIABETOLOGIA,59(6),1276-1286. |
| MLA | Feng, Li,et al."Bavachinin, as a novel natural pan-PPAR agonist, exhibits unique synergistic effects with synthetic PPAR-gamma and PPAR-alpha agonists on carbohydrate and lipid metabolism in db/db and diet-induced obese mice".DIABETOLOGIA 59.6(2016):1276-1286. |
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| feng2016.pdf（841KB） | 开放获取 | CC BY-NC-SA | View Download | |||
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