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Chaetolactam A, an Azaphilone Derivative from the Endophytic Fungus Chaetomium sp. g1 期刊论文
JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 86, 期号: 1, 页码: 475-483
Authors:  Zu,Wen-Yu;  Tang,Jian-Wei;  Hu,Kun;  Zhou,Yuan-Fei;  Gou,Lei-Lei;  Su,Xiao-Zheng;  Lei,Xinxiang;  Sun,Han-Dong;  Puno,Pema-Tenzin
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MASS-SPECTROMETRY  A-D  CASPASE-3  H-1  
Pegaharmalines A and B, two novel beta-carboline alkaloids with unprecedented carbon skeletons from Peganum harmala 期刊论文
RSC ADVANCES, 2014, 卷号: 4, 期号: 96, 页码: 53725-53729
Authors:  Wang, Kai-Bo;  Yuan, Chun-Mao;  Xue, Chun-Mei;  Li, Da-Hong;  Jing, Yong-Kui;  He, Hong-Ping;  Hao, Xiao-Jiang;  Di, Ying-Tong;  Li, Zhan-Lin;  Hua, Hui-Ming;  Hua,HM (reprint author),Shenyang Pharmaceut Univ,Key Lab Struct Based Drug Design & Discovery,Minist Educ,Shenyang 110016,Peoples R China.
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Liverwort Lepidolaena-clavigera  Caspase-3 Inhibitory-activity  Sp No 27  Absolute-configuration  Aspergillus-fumigatus  Tetracyclic Skeleton  Chaetomium-elatum  Phialophora  Metabolites  Acetals  
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
Authors:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua
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One Of The Major compOnents Isolated From The Traditional  2-methyl-1  Chinese Medicine Rubia Yunnanensis  3  Exhibited Inhibitory Activity On The proliferatiOn Of Several  6-trihydroxy-9  HumAn CAncer Cell Lines. The Results From An Annexin V-fitc (fluoresein-5-isothiocyAnate) Apoptosis Assay  10-anthraquinone (Mta)  And Dna Content Analysis Showed That Mta Exerted Cytotoxicity Via Apoptosis Induction And G2/m Cell Cycle  Arrest In Human Cervical carcInoma Hela Cells. Further  Mta Was Found To Induce apopTosis Of Hela Cells  Through The MITochondria-mediated Pathway. It Caused The Translocation Of Bax To The mITochondria And  Release Of Cytochrome c Into The Cytosol  Which Caused The Cleavage Of Caspase And Poly(Adp-ribose)  Polymerase And Finally Triggered The Apoptosis. furThermore  The P53/p21/cdc2-cyclin B1 Signaling Was  Found Related To The G2/m Arrest Caused By Mta. The Over-expression Of P21 And Down-expression Of  Cyclin B1 Caused By Mta Inactivated The cdc2-Cyclin B1 Complex Of G2/m Checkpoint And Finally Caused  The G2/m Arrest In Hela Cells. ThIs Study Demonstrated That Mta Is a Potential Anti-cancer Component Of  R. Yunnanensis  a Folk Anti-cancer Herb Used In Yunnan  China.  
Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus 期刊论文
NATURE IMMUNOLOGY, 2012, 卷号: 13, 期号: 5, 页码: 474-U73
Authors:  Federica Facciotti;  Gundimeda S Ramanjaneyulu;  Marco Lepore;  Sebastiano Sansano;  Marco Cavallari;  Magdalena Kistowska;  Sonja Forss-Petter;  Guanghui Ni;  Alessia Colone;  Amit Singhal;  Johannes Berger;  Chengfeng Xia;  Lucia Mori;  Gennaro De Libero
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Anticancer Drug  Garcinia Oligantha  Xanthone  Apoptosis  Caspase-3  Derivatives  Activation  
Identification and evaluation of apoptotic compounds from Garcinia oligantha 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 卷号: 22, 期号: 6, 页码: 2350-2353
Authors:  Gao, Xue-Mei;  Yu, Ting;  Cui, Ming-zhu;  Pu, Jian-Xin;  Du, Xue;  Han, Quan-bin;  Hu, Qiu-fen;  Liu, Tian-Cheng;  Luo, Kathy Qian;  Xu, Hong-Xi
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Anticancer Drug  Garcinia Oligantha  Xanthone  Apoptosis  Caspase-3  
Quick identification of apoptosis inducer from Isodon eriocalyx by a drug discovery platform composed of analytical high-speed counter-current chromatography and the fluorescence-based caspase-3 biosensor detection 期刊论文
TALANTA, 2010, 卷号: 82, 期号: 4, 页码: 1521-1527
Authors:  Han, Quan-Bin;  Yu, Ting;  Lai, Fanny;  Zhou, Yan;  Feng, Chao;  Wang, Wei-Na;  Fu, Xiao-Hui;  Lau, Clara Bik-San;  Luo, Kathy Q.;  Xu, Hong-Xi;  Sun, Han-Dong;  Fung, Kwok-Pui;  Leung, Ping-Chung
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Analytical High-speed Counter-current Chromatography  Caspase-3 Biosensor  Isodon Eriocalyx  Apoptosis Inducer  Eriocalyxin b  
A petrol ether extract of the roots of Onosma paniculatum induces cell death in a caspase dependent manner 期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2010, 卷号: 129, 期号: 2, 页码: 182-188
Authors:  Rinner, Beate;  Kretschmer, Nadine;  Knausz, Heike;  Mayer, Andrea;  Boechzelt, Herbert;  Hao, Xiao-Jiang;  Heubl, Guenther;  Efferth, Thomas;  Schaider, Helmut;  Bauer, Rudolf
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Onosma Paniculatum  Zicao  Cancer  Cell Cycle  Caspase-3  
Electrospray tandem mass spectrometry of longipedlactone triterpenoids 期刊论文
JOURNAL OF MASS SPECTROMETRY, 2010, 卷号: 45, 期号: 4, 页码: 451-455
Authors:  Wu, Zhi-Jun;  Pu, Jian-Xin;  Li, Li-Mei;  Fang, Dong-Mei;  Qi, Hua-Yi;  Chen, Jian-Zhong;  Li, Guo-You;  Sun, Han-Dong;  Zhang, Guo-Lin
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Onosma Paniculatum  Zicao  Cancer  Cell Cycle  Caspase-3  Traditional Chinese Medicine  Naphthoquinone Derivatives  Induced Apoptosis  Natural-products  Cancer-therapy  In-vitro  Shikonin  Dna  Pharmacogenomics  Induction