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Chaetolactam A, an Azaphilone Derivative from the Endophytic Fungus Chaetomium sp. g1 | |
Zu,Wen-Yu; Tang,Jian-Wei; Hu,Kun![]() ![]() | |
2021 | |
Source Publication | JOURNAL OF ORGANIC CHEMISTRY
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ISSN | 0022-3263 |
Volume | 86Issue:1Pages:475-483 |
Abstract | Chaetolactam A (1), an unprecedented azaphilone derivative bearing a unique 9-oxa-7-azabicyclo[4.2.1]octan-8-onering system, together with two new compounds, 11-epi-chaetomugilide B (2) and chaetomugilide D (3) was isolated from an endophytic fungus, Chaetomium sp. g1. Notably, extensive NMR data analyses, NMR calculations with DP4 and DP4+ analyses, ECD calculations, and the RDC method were employed to establish the structure of 1. Furthermore, 2 exhibited potent apoptosis induction activity by mediating caspase-3 activation and PARP degradation at 3 mu M in HL-60. |
Keyword | MASS-SPECTROMETRY A-D CASPASE-3 H-1 |
DOI | 10.1021/acs.joc.0c02214 |
WOS ID | WOS:000606840200037 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.kib.ac.cn/handle/151853/73362 |
Collection | 中国科学院昆明植物研究所 |
Affiliation | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China |
Recommended Citation GB/T 7714 | Zu,Wen-Yu,Tang,Jian-Wei,Hu,Kun,et al. Chaetolactam A, an Azaphilone Derivative from the Endophytic Fungus Chaetomium sp. g1[J]. JOURNAL OF ORGANIC CHEMISTRY,2021,86(1):475-483. |
APA | Zu,Wen-Yu.,Tang,Jian-Wei.,Hu,Kun.,Zhou,Yuan-Fei.,Gou,Lei-Lei.,...&Puno,Pema-Tenzin.(2021).Chaetolactam A, an Azaphilone Derivative from the Endophytic Fungus Chaetomium sp. g1.JOURNAL OF ORGANIC CHEMISTRY,86(1),475-483. |
MLA | Zu,Wen-Yu,et al."Chaetolactam A, an Azaphilone Derivative from the Endophytic Fungus Chaetomium sp. g1".JOURNAL OF ORGANIC CHEMISTRY 86.1(2021):475-483. |
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098-G11-146-祖-JOC.pd(2707KB) | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download |
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