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Chaetolactam A, an Azaphilone Derivative from the Endophytic Fungus Chaetomium sp. g1
Zu,Wen-Yu; Tang,Jian-Wei; Hu,Kun; Zhou,Yuan-Fei; Gou,Lei-Lei; Su,Xiao-Zheng; Lei,Xinxiang; Sun,Han-Dong; Puno,Pema-Tenzin
2021
Source PublicationJOURNAL OF ORGANIC CHEMISTRY
ISSN0022-3263
Volume86Issue:1Pages:475-483
AbstractChaetolactam A (1), an unprecedented azaphilone derivative bearing a unique 9-oxa-7-azabicyclo[4.2.1]octan-8-onering system, together with two new compounds, 11-epi-chaetomugilide B (2) and chaetomugilide D (3) was isolated from an endophytic fungus, Chaetomium sp. g1. Notably, extensive NMR data analyses, NMR calculations with DP4 and DP4+ analyses, ECD calculations, and the RDC method were employed to establish the structure of 1. Furthermore, 2 exhibited potent apoptosis induction activity by mediating caspase-3 activation and PARP degradation at 3 mu M in HL-60.
KeywordMASS-SPECTROMETRY A-D CASPASE-3 H-1
DOI10.1021/acs.joc.0c02214
WOS IDWOS:000606840200037
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Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/73362
Collection中国科学院昆明植物研究所
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Zu,Wen-Yu,Tang,Jian-Wei,Hu,Kun,et al. Chaetolactam A, an Azaphilone Derivative from the Endophytic Fungus Chaetomium sp. g1[J]. JOURNAL OF ORGANIC CHEMISTRY,2021,86(1):475-483.
APA Zu,Wen-Yu.,Tang,Jian-Wei.,Hu,Kun.,Zhou,Yuan-Fei.,Gou,Lei-Lei.,...&Puno,Pema-Tenzin.(2021).Chaetolactam A, an Azaphilone Derivative from the Endophytic Fungus Chaetomium sp. g1.JOURNAL OF ORGANIC CHEMISTRY,86(1),475-483.
MLA Zu,Wen-Yu,et al."Chaetolactam A, an Azaphilone Derivative from the Endophytic Fungus Chaetomium sp. g1".JOURNAL OF ORGANIC CHEMISTRY 86.1(2021):475-483.
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