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ABT-263 enhances sorafenib-induced apoptosis associated with Akt activity and the expression of Bax and p21 (CIP1/WAF1) in human cancer cells1 期刊论文
出版物, 3111, 期号: 0, 页码: 1-35
作者:  Jingru Li;  Yicheng Chen;  Jiali Wan;  Xin Liu;  Chunrong Yu;  Wenhua Li
Adobe PDF(1198Kb)  |  收藏  |  浏览/下载:200/1  |  提交时间:2017/07/24
Abt-263  Sorafenib  Combination Therapy  Cancer  
The novel benzimidazole derivative BRP-7 inhibits leukotriene biosynthesis in vitro and in vivo by targeting 5-lipoxygenase-activating protein (FLAP)1 期刊论文
出版物, 3111, 期号: 0, 页码: 1-42
作者:  C Pergola;  J Gerstmeier;  B Monch;  B Çaliskan;  S Luderer;  C Weinige;  D Barz;  J Maczewsky;  S Pace;  A Rossi;  L Sautebin;  E Banoglu;  O Werz
Adobe PDF(1387Kb)  |  收藏  |  浏览/下载:308/1  |  提交时间:2017/07/24
Olmesartan prevents cardiac rupture in mice with myocardial infarction by modulating growth differentiation factor 15 and P53 期刊论文
出版物, 3111, 期号: 0, 页码: 1-37
作者:  Baihe Chen;  Di Lu;  Yujuan Fu;  Jingwen Zhang;  Xiaobo Huang;  Shiping Cao;  Dingli Xu;  Jianping Bin;  Masafumi Kitakaze;  Qiaobing Huang;  Yulin Liao
Adobe PDF(1769Kb)  |  收藏  |  浏览/下载:306/1  |  提交时间:2017/07/24
Cardiac Rupture  Olmesartan  P53  Gdf-15  Aldosterone  Myocardial Infarction  
Long-term use of standardised ginkgo biloba extract for theprevention of Alzheimer’s disease (GuidAge): a randomisedplacebo-controlled trial 期刊论文
出版物, 3111, 期号: 0, 页码: 1—9
作者:  Bruno Vellas;  Nicola Coley;  Pierre-Jean Ousset;  Gilles Berrut;  Jean-François Dartigues;  Bruno Dubois;  Hélène Grandjean;  Florence Pasquier;  François Piette;  Philippe Robert;  Jacques Touchon;  Philippe Garnier;  Hélène Mathiex-Fortunet;  Sandrine Andrieu;  for the GuidAge Study Group
Adobe PDF(230Kb)  |  收藏  |  浏览/下载:135/1  |  提交时间:2017/07/21
YC-1 inhibits proliferation of breast cancer cells by downregulating EZH2 expression via activation of c-Cbl and ERK 期刊论文
出版物, 3111, 期号: 0, 页码: 1-46
作者:  Ling-Chu Chang;  Hui-Yi Lin;  Meng-Tung Tsai;  Ruey-Hwang Chou;  Fang-Yu Lee;  Che-Ming Teng;  Min-Tsang Hsieh;  Hsin-Yi Hung;  Li-Jiau Huang;  Yung-Luen Yu;  Sheng-Chu Kuo
Adobe PDF(1357Kb)  |  收藏  |  浏览/下载:328/1  |  提交时间:2017/07/24
Yc-1  Triple-negative Breast Cancer  Erk  Ezh2  C-cbl  
High throughput-screening of native herbal compounds identifies taccaoside A as a cytotoxic compound that mediates RAS signaling in cancer stem cells 期刊论文
PHYTOMEDICINE, 2023, 卷号: 108, 页码: 154492
作者:  Yang,Dong;  Dai,Zhi;  Zhu,Peifeng;  Wang,Gan;  Sun,Bin;  Li,Shirong;  Hao,Junjun;  Wang,Yifen;  Liu,Yaping;  Yu,Shuaishuai;  Lai,Ren;  Luo,Xiao-Dong;  Zhao,Xudong
浏览  |  Adobe PDF(6987Kb)  |  收藏  |  浏览/下载:2/1  |  提交时间:2024/07/17
Natural product  Furostanol saponin  Taccaoside A  Cancer stem cell  RAS  STEROIDAL SAPONINS  NATURAL-PRODUCTS  PI3K/AKT  PROLIFERATION  MAINTENANCE  STATISTICS  MAPK/ERK  
Discovery of diverse sesquiterpenoids from Magnolia grandiflora with cytotoxic activities by inducing cell apoptosis 期刊论文
BIOORGANIC CHEMISTRY, 2023, 卷号: 139, 页码: 106707
作者:  Xu,Shuangyu;  Tang,Yunyan;  Li,Yanan;  Yang,Jue;  Gu,Wei;  Hao,Xiaojiang;  Yuan,Chunmao
浏览  |  Adobe PDF(5040Kb)  |  收藏  |  浏览/下载:2/1  |  提交时间:2024/07/22
Magnolia grandiflora  Sesquiterpenoids  Isolation and structural modification  Cytotoxic activity  Apoptosis  LACTONES  DERIVATIVES  LEAVES  AGENTS  
Microbiota-derived short-chain fatty acids mediate the effects of dengzhan shengmai in ameliorating cerebral ischemia via the gut-brain axis 期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2023, 卷号: 306, 页码: 116158
作者:  Guo,Hui-Hui;  Shen,Hao-Ran;  Tang,Ming-Ze;  Sheng,Ning;  Ding,Xiao;  Lin,Yuan;  Zhang,Jin-Lan;  Jiang,Jian-Dong;  Gao,Tian-Le;  Wang,Lu-Lu;  Han,Yan-Xing
浏览  |  Adobe PDF(14966Kb)  |  收藏  |  浏览/下载:0/0  |  提交时间:2024/07/25
Dengzhan shengmai  Microbiota-gut-brain axis  Short-chain fatty acids  Cerebral ischemia  Gut barrier  Fecal microbiota transplantation  STROKE  SCUTELLARIN  
雷公藤制剂对消化系统的毒性机理研究 学位论文
: 中国科学院大学, 2022
作者:  代曼云
Adobe PDF(10574Kb)  |  收藏  |  浏览/下载:11/0  |  提交时间:2024/05/14
代谢组学,雷公藤,药源性肝损伤,消化性溃疡,FXR,ET-1, 肠道血管屏障  Metabolomics, Tripterygium wilfordii, Drug-induced liver injury, peptic ulcer disease, FXR, ET-1, intestinal vascular barrier.  
肿瘤细胞抗凋亡调控因子c-FLIPs的结构与功能研究 学位论文
: 中国科学院大学, 2022
作者:  白志强
Adobe PDF(5263Kb)  |  收藏  |  浏览/下载:12/0  |  提交时间:2024/05/14
细胞凋亡  Apoptosis, c-FLIPS, NMR, Structural biology  c-FLIPS  核磁共振  结构生物学