Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus

doi:10.1038/ni.2245

	Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus
	Federica Facciotti; Gundimeda S Ramanjaneyulu; Marco Lepore; Sebastiano Sansano; Marco Cavallari; Magdalena Kistowska; Sonja Forss-Petter; Guanghui Ni; Alessia Colone; Amit Singhal; Johannes Berger; Chengfeng Xia; Lucia Mori; Gennaro De Libero
通讯作者	De Libero, G (reprint author), Univ Basel Hosp, Dept Biomed, CH-4031 Basel, Switzerland, gennaro_delibero@immunol.a-star.edu.sg
	2012-05-01
发表期刊	NATURE IMMUNOLOGY
ISSN	1529-2908
卷号	13 期号:5 页码:474-U73
摘要	The development and maturation of semi-invariant natural killer T cells (iNKT cells) rely on the recognition of self antigens presented by CD1d restriction molecules in thymus. The nature of the stimulatory thymic self lipids remains elusive. We isolated lipids from thymocytes and found that ether-bonded mono-alkyl glycerophosphates and the precursors and degradation products of plasmalogens stimulated iNKT cells. Synthetic analogs showed high potency in activating thymic and peripheral iNKT cells. Mice deficient in the peroxisomal enzyme glyceronephosphate O-acyltransferase (GNPAT), essential for the synthesis of ether lipids, had significant alteration of the thymic maturation of iNKT cells and fewer iNKT cells in both thymus and peripheral organs, which confirmed the role of ether-bonded lipids as iNKT cell antigens. Thus, peroxisome-derived lipids are nonredundant self antigens required for the generation of a full iNKT cell repertoire.
关键词	Anticancer Drug Garcinia Oligantha Xanthone Apoptosis Caspase-3 Derivatives Activation
学科领域	Immunology
DOI	10.1038/ni.2245
收录类别	SCI
语种	英语
WOS记录号	WOS:000303048400011
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/10361
专题	植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Federica Facciotti,Gundimeda S Ramanjaneyulu,Marco Lepore,et al. Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus[J]. NATURE IMMUNOLOGY,2012,13(5):474-U73.
APA	Federica Facciotti.,Gundimeda S Ramanjaneyulu.,Marco Lepore.,Sebastiano Sansano.,Marco Cavallari.,...&Gennaro De Libero.(2012).Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus.NATURE IMMUNOLOGY,13(5),474-U73.
MLA	Federica Facciotti,et al."Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus".NATURE IMMUNOLOGY 13.5(2012):474-U73.

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