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题名: Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus
作者: Federica Facciotti; Gundimeda S Ramanjaneyulu; Marco Lepore; Sebastiano Sansano; Marco Cavallari; Magdalena Kistowska; Sonja Forss-Petter; Guanghui Ni; Alessia Colone; Amit Singhal; Johannes Berger; Chengfeng Xia; Lucia Mori; Gennaro De Libero
刊名: NATURE IMMUNOLOGY
关键词: Anticancer drug ; Garcinia oligantha ; Xanthone ; Apoptosis ; Caspase-3 ; DERIVATIVES ; ACTIVATION
英文摘要: The development and maturation of semi-invariant natural killer T cells (iNKT cells) rely on the recognition of self antigens presented by CD1d restriction molecules in thymus. The nature of the stimulatory thymic self lipids remains elusive. We isolated lipids from thymocytes and found that ether-bonded mono-alkyl glycerophosphates and the precursors and degradation products of plasmalogens stimulated iNKT cells. Synthetic analogs showed high potency in activating thymic and peripheral iNKT cells. Mice deficient in the peroxisomal enzyme glyceronephosphate O-acyltransferase (GNPAT), essential for the synthesis of ether lipids, had significant alteration of the thymic maturation of iNKT cells and fewer iNKT cells in both thymus and peripheral organs, which confirmed the role of ether-bonded lipids as iNKT cell antigens. Thus, peroxisome-derived lipids are nonredundant self antigens required for the generation of a full iNKT cell repertoire.
出版日期: 2012-05-01
卷号: 13, 期号:5, 页码:474-U73
语种: 英语
收录类别: SCI
学科分类: Immunology
ISSN号: 1529-2908
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/10361
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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Recommended Citation:
Facciotti, F; Ramanjaneyulu, GS; Lepore, M; Sansano, S; Cavallari, M; Kistowska, M; Forss-Petter, S; Ni, GH; Colone, A; Singhal, A; Berger, J; Xia, CF; Mori, L; De Libero, G.Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus,NATURE IMMUNOLOGY,2012,13(5):474-U73
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文件名: Nature Immun 2012.13.474.pdf
格式: Adobe PDF
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