Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus
Federica Facciotti; Gundimeda S Ramanjaneyulu; Marco Lepore; Sebastiano Sansano; Marco Cavallari; Magdalena Kistowska; Sonja Forss-Petter; Guanghui Ni; Alessia Colone; Amit Singhal; Johannes Berger; Chengfeng Xia; Lucia Mori; Gennaro De Libero
2012-05-01
发表期刊NATURE IMMUNOLOGY
ISSN1529-2908
卷号13期号:5页码:474-U73
摘要The development and maturation of semi-invariant natural killer T cells (iNKT cells) rely on the recognition of self antigens presented by CD1d restriction molecules in thymus. The nature of the stimulatory thymic self lipids remains elusive. We isolated lipids from thymocytes and found that ether-bonded mono-alkyl glycerophosphates and the precursors and degradation products of plasmalogens stimulated iNKT cells. Synthetic analogs showed high potency in activating thymic and peripheral iNKT cells. Mice deficient in the peroxisomal enzyme glyceronephosphate O-acyltransferase (GNPAT), essential for the synthesis of ether lipids, had significant alteration of the thymic maturation of iNKT cells and fewer iNKT cells in both thymus and peripheral organs, which confirmed the role of ether-bonded lipids as iNKT cell antigens. Thus, peroxisome-derived lipids are nonredundant self antigens required for the generation of a full iNKT cell repertoire.
关键词Anticancer Drug Garcinia Oligantha Xanthone Apoptosis Caspase-3 Derivatives Activation
资助信息Swiss National Foundation[3100AO-122464/1, Sinergia CRS133-124819]; Yunnan High-End Technology Professionals Introduction Program[2010CI117]; Oncosuisse
收录类别SCI
语种英语
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/10361
专题植物化学与西部植物资源持续利用国家重点实验室
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Federica Facciotti,Gundimeda S Ramanjaneyulu,Marco Lepore,et al. Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus[J]. NATURE IMMUNOLOGY,2012,13(5):474-U73.
APA Federica Facciotti.,Gundimeda S Ramanjaneyulu.,Marco Lepore.,Sebastiano Sansano.,Marco Cavallari.,...&Gennaro De Libero.(2012).Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus.NATURE IMMUNOLOGY,13(5),474-U73.
MLA Federica Facciotti,et al."Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus".NATURE IMMUNOLOGY 13.5(2012):474-U73.
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