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USP47 maintains the stemness of colorectal cancer cells and is inhibited by parthenolide 期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021, 卷号: 562, 页码: 21-28
作者:  Zhang,Shaohua;  Ju,Xiaoman;  Yang,Qihong;  Zhu,Yiying;  Fan,Dongmei;  Su,Guifeng;  Kong,Lingmei;  Li,Yan
浏览  |  Adobe PDF(2615Kb)  |  收藏  |  浏览/下载：156/37  |  提交时间：2022/04/02
USP47  Cancer stem cell  Colorectal cancer  Parthenolide  Deubiquitinase  SESQUITERPENE LACTONE PARTHENOLIDE  DEUBIQUITINASES  STABILIZATION  LEUKEMIA  
Parthenolide inhibits ubiquitin-specific peptidase 7 (USP7), Wnt signaling, and colorectal cancer cell growth 期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2020
作者:  Li, Xue;  Kong, Lingmei;  Yang, Qihong;  Duan, Aizhu;  Ju, Xiaoman;  Cai, Bicheng;  Chen, Lin;  An, Tao;  Li, Yan
浏览  |  Adobe PDF(2381Kb)  |  收藏  |  浏览/下载：147/57  |  提交时间：2021/01/05
RNF220 is required for cerebellum development and regulates medulloblastoma progression through epigenetic modulation of Shh signaling 期刊论文
DEVELOPMENT, 2020
作者:  Ma, Pengcheng;  An, Tao;  Zhu, Liang;  Zhang, Longlong;  Wang, Huishan;  Ren, Biyu;  Sun, Bin;  Zhou, Xia;  Li, Yan;  Mao, Bingyu
浏览  |  Adobe PDF(1986Kb)  |  收藏  |  浏览/下载：114/32  |  提交时间：2021/01/05
Fine-Tuning of Shh/Gli Signaling Gradient by Non-proteolytic Ubiquitination during Neural Patterning 期刊论文
CELL REPORTS, 2019, 卷号: 28, 期号: 2, 页码: 541-+
作者:  Ma, Pengcheng;  Song, Ning-Ning;  Li, Yongxin;  Zhang, Qiong;  Zhang, Lei;  Zhang, Longlong;  Kong, Qinghua;  Ma, Li;  Yang, Xiangcai;  Ren, Biyu;  Li, Chaocui;  Zhao, Xudong;  Li, Yan;  Xu, Ying;  Gao, Xiang;  Ding, Yu-Qiang;  Mao, Bingyu
浏览  |  Adobe PDF(5547Kb)  |  收藏  |  浏览/下载：253/45  |  提交时间：2019/08/19
Design, Synthesis, and Biological Activities of Vibsanin B Derivatives: A New Class of HSP90 C-Terminal Inhibitors 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 21, 页码: 9053-9066
作者:  Shao, Li-Dong;  Su, Jia;  Ye, Baixin;  Liu, Jiang-Xin;  Zuo, Zhi-Li;  Li, Yan;  Wang, Yue-Ying;  Xia, Chengfeng;  Zhao, Qin-Shi
浏览  |  Adobe PDF(5724Kb)  |  收藏  |  浏览/下载：385/42  |  提交时间：2017/12/18
Star-PAP, a poly(A) polymerase, functions as a tumor suppressor in an orthotopic human breast cancer model 期刊论文
CELL DEATH & DISEASE, 2017, 卷号: 8, 期号: 1, 页码: e2582
作者:  Yu, C.;  Gong, Y.;  Zhou, H.;  Wang, M.;  Kong, L.;  Liu, J.;  An, T.;  Zhu, H.;  Li, Y.
浏览  |  Adobe PDF(3022Kb)  |  收藏  |  浏览/下载：201/45  |  提交时间：2017/04/19
The Ubiquitin Ligase RNF220 Enhances Canonical Wnt Signaling through USP7-Mediated Deubiquitination of beta-Catenin 期刊论文
MOLECULAR AND CELLULAR BIOLOGY, 2014, 卷号: 34, 期号: 23, 页码: 4355-4366
作者:  Ma, Pengcheng;  Yang, Xiangcai;  Kong, Qinghua;  Li, Chaocui;  Yang, Shuangjuan;  Li, Yan;  Mao, Bingyu;  Mao,BY (reprint author),Kunming Inst Zool,State Key Lab Genet Resources & Evolut,Kunming,Peoples R China.;  mao@mail.kiz.ac.cn
浏览  |  Adobe PDF(1708Kb)  |  收藏  |  浏览/下载：287/58  |  提交时间：2015/01/20
Stem-cell Fate  Shoot Apical Meristem  Arabidopsis Shoot  Crabs-claw  Nectary Development  Expression  Thaliana  Family  Loop  Polarity  Iayabby2  Ad-abaxial Polarity  Incarvillea Arguta  Arabidopsis Thaliana  
Identification and validation of p50 as the cellular target of eriocalyxin B 期刊论文
ONCOTARGET, 2014, 卷号: 5, 期号: 22, 页码: 11354-11364
作者:  Kong, Ling-Mei;  Deng, Xu;  Zuo, Zhi-Li;  Sun, Han-Dong;  Zhao, Qin-Shi;  Li, Yan
浏览  |  Adobe PDF(3014Kb)  |  收藏  |  浏览/下载：291/72  |  提交时间：2015/06/17
Erib  Activity-based Probes  P50  Nf-kappa b Signaling  Apoptosis  
Synthesis and cytotoxic activity of novel hybrid compounds between 2-alkylbenzofuran and imidazole 期刊论文
MEDICINAL CHEMISTRY RESEARCH, 2014, 卷号: 23, 期号: 3, 页码: 1599-1611
作者:  Wan, Wei-Chao;  Chen, Wen;  Liu, Lan-Xiang;  Li, Yan;  Yang, Li-Juan;  Deng, Xiao-Yan;  Zhang, Hong-Bin;  Yang, Xiao-Dong
Adobe PDF(509Kb)  |  收藏  |  浏览/下载：802/530  |  提交时间：2014/04/09
Hybrid Compound  Benzofuran  Imidazole  Cytotoxic Activity  Structure-activity Relationships  Molecular Docking  
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua
浏览  |  Adobe PDF(6299Kb)  |  收藏  |  浏览/下载：271/44  |  提交时间：2015/05/14
One Of The Major compOnents Isolated From The Traditional  2-methyl-1  Chinese Medicine Rubia Yunnanensis  3  Exhibited Inhibitory Activity On The proliferatiOn Of Several  6-trihydroxy-9  HumAn CAncer Cell Lines. The Results From An Annexin V-fitc (fluoresein-5-isothiocyAnate) Apoptosis Assay  10-anthraquinone (Mta)  And Dna Content Analysis Showed That Mta Exerted Cytotoxicity Via Apoptosis Induction And G2/m Cell Cycle  Arrest In Human Cervical carcInoma Hela Cells. Further  Mta Was Found To Induce apopTosis Of Hela Cells  Through The MITochondria-mediated Pathway. It Caused The Translocation Of Bax To The mITochondria And  Release Of Cytochrome c Into The Cytosol  Which Caused The Cleavage Of Caspase And Poly(Adp-ribose)  Polymerase And Finally Triggered The Apoptosis. furThermore  The P53/p21/cdc2-cyclin B1 Signaling Was  Found Related To The G2/m Arrest Caused By Mta. The Over-expression Of P21 And Down-expression Of  Cyclin B1 Caused By Mta Inactivated The cdc2-Cyclin B1 Complex Of G2/m Checkpoint And Finally Caused  The G2/m Arrest In Hela Cells. ThIs Study Demonstrated That Mta Is a Potential Anti-cancer Component Of  R. Yunnanensis  a Folk Anti-cancer Herb Used In Yunnan  China.