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Discovery of Natural Potent HMG-CoA Reductase Degraders for Lowering Cholesterol 期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2023
作者:  Su,Xiao-Zheng;  Zhang,Lin-Fei;  Hu,Kun;  An,Yang;  Zhang,Qiao-Peng;  Tang,Jian-Wei;  Yan,Bing-Chao;  Li,Xing-Ren;  Cai,Jie;  Li,Xiao-Nian;  Sun,Han-Dong;  Jiang,Shi-You;  Puno,Pema-Tenzin
浏览  |  Adobe PDF(7289Kb)  |  收藏  |  浏览/下载：13/1  |  提交时间：2024/07/10
Enzymes  Meroterpenoids  Natural Products  Proteomics  Semisynthesis  STATIN  FUNGUS  RISK  ACID  
A Mushroom P450-Monooxygenase Enables Regioand Stereoselective Biocatalytic Synthesis of Epoxycyclohexenones 期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2023, 卷号: 62, 期号: 49
作者:  Yang,Yan-Long;  Zhou,Man;  Yang,Lin;  Gressler,Markus;  Rassbach,Johannes;  Wurlitzer,Jacob M.;  Zeng,Ying;  Gao,Kun;  Hoffmeister,Dirk
浏览  |  Adobe PDF(1998Kb)  |  收藏  |  浏览/下载：10/1  |  提交时间：2024/07/10
Biocatalysis  Biosynthesis  Cytochrome P450  Epoxycyclohexenone  Natural Products  OPPOSITE FACIAL SPECIFICITY  NATURAL-PRODUCTS  STREPTOMYCES LL-C10037  BIOSYNTHESIS  EPOXYQUINONE  CYTOCHROME-P450  FERMENTATION  PANEPOXYDONE  EPOXIDATION  INHIBITION  
A Cryptic Plant Terpene Cyclase Producing Unconventional 18-and 14-Membered Macrocyclic C-25 and C-20 Terpenoids with Immunosuppressive Activity 期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 卷号: 60, 期号: 48, 页码: 25468-25476
作者:  Chen,Yue-Gui;  Li,De-Sen;  Ling,Yi;  Liu,Yan-Chun;  Zuo,Zhi-Li;  Gan,Li-She;  Luo,Shi-Hong;  Hua,Juan;  Chen,Ding-Yuan;  Xu,Fan;  Li,Man;  Guo,Kai;  Liu,Yan;  Gershenzon,Jonathan;  Li,Sheng-Hong
浏览  |  Adobe PDF(2177Kb)  |  收藏  |  浏览/下载：137/60  |  提交时间：2022/04/02
enzyme engineering  immunosuppressive activity  Leucosceptrum canum  macrocyclic terpenoids  sesterterpene synthase  GERANYLFARNESYL DIPHOSPHATE SYNTHASE  GLANDULAR TRICHOMES  LEUCOSCEPTRUM-CANUM  SCALE INSECT  SESTERTERPENOIDS  CONVERSION  EVOLUTION  PRECURSOR  HARBOR  
Bioinspired Network Analysis Enabled Divergent Syntheses and Structure Revision of Pentacyclic Cytochalasans 期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 卷号: 60, 期号: 29, 页码: 15963-15971
作者:  Wu,Hai;  Ding,Yiming;  Hu,Kun;  Long,Xianwen;  Qu,Chunlei;  Puno,Pema-Tenzin;  Deng,Jun
浏览  |  Adobe PDF(2675Kb)  |  收藏  |  浏览/下载：105/25  |  提交时间：2022/04/02
bioinspired network analysis  biomimetic synthesis  natural products  pentacyclic cytochalasans  structure elucidation  DIELS-ALDER REACTION  ISOINDOLONE NUCLEUS  RING-SYSTEM  MEROCYTOCHALASANS  REASSIGNMENT  DESATURATION  GENERATION  ALKALOIDS  CARBONATE  SKELETONS  
Merging Reagent Modulation and Remote Anchimeric Assistance for Glycosylation: Highly Stereoselective Synthesis of alpha-Glycans up to a 30-mer 期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 卷号: 60, 期号: 22, 页码: 12597-12606
作者:  Zhang,Yunqin;  He,Haiqing;  Chen,Zixi;  Huang,Yingying;  Xiang,Guisheng;  Li,Penghua;  Yang,Xingkuan;  Lu,Gang;  Xiao,Guozhi
浏览  |  Adobe PDF(3663Kb)  |  收藏  |  浏览/下载：102/22  |  提交时间：2022/04/02
1  2-cis glycosylation  reagent modulation  remote anchimeric assistance  structure elucidation  synthetic methods  
(-)-Isoscopariusin A, a Naturally Occurring Immunosuppressive Meroditerpenoid: Structure Elucidation and Scalable Chemical Synthesis 期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 卷号: 60, 期号: 23, 页码: 12859-12867
作者:  Yan,Bing-Chao;  Zhou,Min;  Li,Jian;  Li,Xiao-Nian;  He,Shi-Jun;  Zuo,Jian-Ping;  Sun,Han-Dong;  Li,Ang;  Puno,Pema-Tenzin
浏览  |  Adobe PDF(1930Kb)  |  收藏  |  浏览/下载：114/25  |  提交时间：2022/04/02
bioactivity  cyclobutane  natural products  scalable synthesis  structure elucidation  
Functional Genome Mining Reveals a Class V Lanthipeptide Containing ad-Amino Acid Introduced by an F420H2-Dependent Reductase 期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020
作者:  Xu, Min;  Zhang, Fei;  Cheng, Zhuo;  Bashiri, Ghader;  Wang, Jing;  Hong, Jiali;  Wang, Yemin;  Xu, Lijun;  Chen, Xuefei;  Huang, Sheng-Xiong;  Lin, Shuangjun;  Deng, Zixin;  Tao, Meifeng
浏览  |  Adobe PDF(1545Kb)  |  收藏  |  浏览/下载：188/46  |  提交时间：2021/01/05
Modular Synthesis of Nona-Decasaccharide Motif from Psidium guajava Polysaccharides: Orthogonal One-Pot Glycosylation Strategy 期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020
作者:  Zhang, Yunqin;  Chen, Zixi;  Huang, Yingying;  He, Shaojun;  Yang, Xingkuan;  Wu, Zhibing;  Wang, Xiufang;  Xiao, Guozhi
浏览  |  Adobe PDF(10000Kb)  |  收藏  |  浏览/下载：73/7  |  提交时间：2021/01/05
A Hydrolase-Catalyzed Cyclization Forms the Fused Bicyclic beta-Lactone in Vibralactone 期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020
作者:  Feng, Ke-Na;  Yang, Yan-Long;  Xu, Yu-Xing;  Zhang, Yue;  Feng, Tao;  Huang, Sheng-Xiong;  Liu, Ji-Kai;  Zeng, Ying
浏览  |  Adobe PDF(1157Kb)  |  收藏  |  浏览/下载：150/33  |  提交时间：2021/01/05
Total Synthesis of (-)-Perezoperezone through an Intermolecular [5+2] Homodimerization of Hydroxy p-Quinone 期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2019, 页码: 6
作者:  Long, Yang;  Ding, Yiming;  Wu, Hai;  Qu, Chunlei;  Liang, Hong;  Zhang, Min;  Zhao, Xiaoli;  Long, Xianwen;  Wang, Shu;  Puno, Pema-Tenzin;  Deng, Jun
浏览  |  Adobe PDF(2181Kb)  |  收藏  |  浏览/下载：323/86  |  提交时间：2020/03/26
5+2 cycloaddition  dimerization  natural products  perezoperezone  total synthesis