KIB OpenIR
Bioinspired Network Analysis Enabled Divergent Syntheses and Structure Revision of Pentacyclic Cytochalasans
Wu,Hai; Ding,Yiming; Hu,Kun; Long,Xianwen; Qu,Chunlei; Puno,Pema-Tenzin; Deng,Jun
2021
发表期刊ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN1433-7851
卷号60期号:29页码:15963-15971
摘要We accomplished the divergent total syntheses of ten pentacyclic cytochalasans (aspergillin PZ, trichodermone, trichoderones, flavipesines, and flavichalasines) from a common precursor aspochalasin D and revised the structures of trichoderone B, spicochalasin A, flavichalasine C, aspergilluchalasin based on structure network analysis of the cytochalasans biosynthetic pathways and DFT calculations. The key steps of the syntheses include transannular alkene/epoxyalkene and carbonyl-ene cyclizations to establish the C/D ring of pentacyclic aspochalasans. Our bioinspired approach to these pentacyclic cytochalasans validate the proposed biosynthetic speculation from a chemical view and provide a platform for the synthesis of more than 400 valuable cytochalasans bearing different macrocycles and amino-acid residues.
关键词bioinspired network analysis biomimetic synthesis natural products pentacyclic cytochalasans structure elucidation DIELS-ALDER REACTION ISOINDOLONE NUCLEUS RING-SYSTEM MEROCYTOCHALASANS REASSIGNMENT DESATURATION GENERATION ALKALOIDS CARBONATE SKELETONS
DOI10.1002/anie.202102831
WOS记录号WOS:000662299400001
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/73360
专题中国科学院昆明植物研究所
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Nankai Univ, Coll Chem, State Key Lab, Tianjin 300071, Peoples R China
4.Nankai Univ, Coll Chem, Inst Elementoorgan Chem, Tianjin 300071, Peoples R China
推荐引用方式
GB/T 7714
Wu,Hai,Ding,Yiming,Hu,Kun,et al. Bioinspired Network Analysis Enabled Divergent Syntheses and Structure Revision of Pentacyclic Cytochalasans[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2021,60(29):15963-15971.
APA Wu,Hai.,Ding,Yiming.,Hu,Kun.,Long,Xianwen.,Qu,Chunlei.,...&Deng,Jun.(2021).Bioinspired Network Analysis Enabled Divergent Syntheses and Structure Revision of Pentacyclic Cytochalasans.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,60(29),15963-15971.
MLA Wu,Hai,et al."Bioinspired Network Analysis Enabled Divergent Syntheses and Structure Revision of Pentacyclic Cytochalasans".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 60.29(2021):15963-15971.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
143-I05-145-吴海-胡坤-An(2675KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wu,Hai]的文章
[Ding,Yiming]的文章
[Hu,Kun]的文章
百度学术
百度学术中相似的文章
[Wu,Hai]的文章
[Ding,Yiming]的文章
[Hu,Kun]的文章
必应学术
必应学术中相似的文章
[Wu,Hai]的文章
[Ding,Yiming]的文章
[Hu,Kun]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 143-I05-145-吴海-胡坤-Angew.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。