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中国科学院昆明植物研究所知识管理系统
Knowledge Management System of Kunming Institute of Botany,CAS
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植物化学与西部植物资... [8]
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Physalis peruviana-Derived 4 beta-Hydroxywithanolide E, a Novel Antagonist of Wnt Signaling, Inhibits Colorectal Cancer In Vitro and In Vivo
期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 6, 页码: 13
作者:
Ye, Zhen-Nan
;
Yuan, Feng
;
Liu, Jie-Qing
;
Peng, Xing-Rong
;
An, Tao
;
Li, Xue
;
Kong, Ling-Mei
;
Qiu, Ming-Hua
;
Li, Yan
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浏览/下载:187/39
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提交时间:2019/07/29
4 beta HWE
Wnt signaling pathway
beta-catenin
colorectal cancer
Rubipodanones A-D, naphthohydroquinone dimers from rhizomes of &ITRubia podantha &IT
期刊论文
PHYTOCHEMISTRY, 2018, 卷号: 145, 页码: 153-160
作者:
Wang, Zhe
;
Zhao, Si-Meng
;
Hu, Yan-Yun
;
Feng, Li
;
Zhao, Li-Mei
;
Di, Ying-Tong
;
Tan, Ning-Hua
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浏览/下载:251/53
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提交时间:2018/05/08
Rubia Podantha
Rubiaceae
Naphthohydroquinone Dimers
Rubipodanones A-d
Cytotoxicity
Nf-kappa b Signaling Pathway
1,4-Naphthoquinone Triggers Nematode Lethality by Inducing Oxidative Stress and Activating Insulin/IGF Signaling Pathway in Caenorhabditis elegans10.3390/molecules22050798
期刊论文
MOLECULES, 2017, 卷号: 22, 期号: 5, 页码: 798
作者:
Wang, Jia
;
Zeng, Guangzhi
;
Huang, Xiaobing
;
Wang, Zhe
;
Tan, Ninghua
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浏览/下载:226/41
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提交时间:2017/07/31
Plant-parasitic Nematode
Phytochemical
Nematocidal
Oxidative Stress
1
Insulin/igf Signaling Pathway
4-naphthoquinone
Caenorhabditis Elegans
Rubicordins A-C, new cyclopeptides from Rubia cordifolia with cytotoxicity and inhibiting NF-kappa B signaling pathway
期刊论文
TETRAHEDRON, 2015, 卷号: 71, 期号: 52, 页码: 9673-9678
作者:
Chen, Xiao-Qiang
;
Zhao, Si-Meng
;
Wang, Zhe
;
Zeng, Guang-Zhi
;
Huang, Mao-Bo
;
Tan, Ning-Hua
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浏览/下载:721/152
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提交时间:2016/02/01
Rubia Cordifolia
Rubicordins A-c
Cyclopeptides
Cytotoxicity
Nf-kappa b Signaling Pathway
Neoalbaconol induces cell death through necroptosis by regulating RIPK-dependent autocrine TNF alpha and ROS production
期刊论文
ONCOTARGET, 2015, 卷号: 6, 期号: 4, 页码: 1995-2008
作者:
Yu, Xinfang
;
Deng, Qipan
;
Li, Wei
;
Xiao, Lanbo
;
Luo, Xiangjian
;
Liu, Xiaolan
;
Yang, Lifang
;
Peng, Songling
;
Ding, Zhihui
;
Feng, Tao
;
Zhou, Jian
;
Fan, Jia
;
Bode, Ann M.
;
Dong, Zigang
;
Liu, Jikai
;
Cao, Ya
;
Liu,JK (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Beijing 100864,Yunnan,Peoples R China.
;
jkliu@mail.kib.ac.cn
;
ycao98@vip.sina.com
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浏览/下载:441/61
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提交时间:2015/06/29
Necoalbaconol
Necroptosis
Ripk
Tnf Alpha
Nf-kappa b Signaling Pathway
Ros
Adenanthin targets peroxiredoxin I/II to kill hepatocellular carcinoma cells
期刊论文
CELL DEATH & DISEASE, 2014, 卷号: 5, 页码: e1400
作者:
Hou, J-K
;
Huang, Y.
;
He, W.
;
Yan, Z-W
;
Fan, L.
;
Liu, M-H
;
Xiao, W-L
;
Sun, H-D
;
Chen, G-Q
;
Chen,GQ (reprint author),Shandong Jiaotong Univ,Sch Med,Dept Pathophysiol,280 Chong Qing South Rd,Shanghai 200025,Peoples R China.
;
huangying@shsmu.edu.cn
;
hdsun@mail.kib.ac.cn
;
chengq@shsmu.edu.cn
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浏览/下载:275/71
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提交时间:2014/11/25
Reactive Oxygen
Cancer-cells
Signaling Pathway
Mechanisms
Apoptosis
Ros
Roles
Death
Prdx1
Cucurbitacin E Induces Cell Cycle G2/M Phase Arrest and Apoptosis in Triple Negative Breast Cancer
期刊论文
PLOS ONE, 2014, 卷号: 9, 期号: 7, 页码: e103760
作者:
Kong, Yanjie
;
Chen, Jianchao
;
Zhou, Zhongmei
;
Xia, Houjun
;
Qiu, Ming-Hua
;
Chen, Ceshi
;
Qiu,MH (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming,Yunnan,Peoples R China.
;
qiuminghua@mail.kib.ac.cn
;
chenc@mail.kiz.ac.cn
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浏览/下载:216/43
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提交时间:2014/11/25
Inhibitory-activity
Signaling Pathway
Carcinoma
Growth
Activation
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells
期刊论文
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:
Zeng, Guang-Zhi
;
Fan, Jun-Ting
;
Xu, Jun-Ju
;
Li, Yan
;
Tan, Ning-Hua
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浏览/下载:282/50
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提交时间:2015/05/14
One Of The Major compOnents Isolated From The Traditional
2-methyl-1
Chinese Medicine Rubia Yunnanensis
3
Exhibited Inhibitory Activity On The proliferatiOn Of Several
6-trihydroxy-9
HumAn CAncer Cell Lines. The Results From An Annexin V-fitc (fluoresein-5-isothiocyAnate) Apoptosis Assay
10-anthraquinone (Mta)
And Dna Content Analysis Showed That Mta Exerted Cytotoxicity Via Apoptosis Induction And G2/m Cell Cycle
Arrest In Human Cervical carcInoma Hela Cells. Further
Mta Was Found To Induce apopTosis Of Hela Cells
Through The MITochondria-mediated Pathway. It Caused The Translocation Of Bax To The mITochondria And
Release Of Cytochrome c Into The Cytosol
Which Caused The Cleavage Of Caspase And Poly(Adp-ribose)
Polymerase And Finally Triggered The Apoptosis. furThermore
The P53/p21/cdc2-cyclin B1 Signaling Was
Found Related To The G2/m Arrest Caused By Mta. The Over-expression Of P21 And Down-expression Of
Cyclin B1 Caused By Mta Inactivated The cdc2-Cyclin B1 Complex Of G2/m Checkpoint And Finally Caused
The G2/m Arrest In Hela Cells. ThIs Study Demonstrated That Mta Is a Potential Anti-cancer Component Of
R. Yunnanensis
a Folk Anti-cancer Herb Used In Yunnan
China.