Rubipodanones A-D, naphthohydroquinone dimers from rhizomes of &ITRubia podantha &IT
Wang, Zhe1,2,3; Zhao, Si-Meng3; Hu, Yan-Yun1,2; Feng, Li1,2; Zhao, Li-Mei3; Di, Ying-Tong3; Tan, Ning-Hua1,2,3
2018
发表期刊PHYTOCHEMISTRY
ISSN0031-9422
卷号145页码:153-160
摘要Four previously undescribed naphthohydroquinone dimers named rubipodanones AD, together with 19 known quinones containing three known napthohydroquinone dimers named rubioncolin C, methyl 5-hydroxy-dinaphtho[1,2-2',3']furan-7,12-dione-6-carboxylate and rubialatin B, were isolated from the roots and rhizomes of Rubia podantha. Their structures and absolute configurations were determined mainly by NMR, X-ray diffraction, and computational methods. Rubipodanones C and D, the glycosides of rubipodanone A and a pair of C-3 epimer, are the first identified dimeric napthohydroquinone glycosides from the Rubia plants. All naphthohydroquinone dimers were evaluated for their cytotoxicities against ten tumor cell lines and effects on the tumor-associated NF-kappa B signaling pathway, and rubioncolin C showed the best cytotoxicity with IC50 value of 1.53 mu M and NF-kappa B inhibitory activity with IC50 value of 2.97 mu M. These results also demonstrated that the key roles of C-3 configuration and sugar group for biological activities of rubipodanone C. (C) 2017 Elsevier Ltd. All rights reserved.
关键词Rubia Podantha Rubiaceae Naphthohydroquinone Dimers Rubipodanones A-d Cytotoxicity Nf-kappa b Signaling Pathway
DOI10.1016/j.phytochem.2017.11.002
语种英语
WOS记录号WOS:000423245300018
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/60585
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.China Pharmaceut Univ, Sch Tradit Chinese Pharm, Nanjing 211198, Jiangsu, Peoples R China
2.China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 211198, Jiangsu, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Chi, Kunming 650201, Yunnan, Peoples R China
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Wang, Zhe,Zhao, Si-Meng,Hu, Yan-Yun,et al. Rubipodanones A-D, naphthohydroquinone dimers from rhizomes of &ITRubia podantha &IT[J]. PHYTOCHEMISTRY,2018,145:153-160.
APA Wang, Zhe.,Zhao, Si-Meng.,Hu, Yan-Yun.,Feng, Li.,Zhao, Li-Mei.,...&Tan, Ning-Hua.(2018).Rubipodanones A-D, naphthohydroquinone dimers from rhizomes of &ITRubia podantha &IT.PHYTOCHEMISTRY,145,153-160.
MLA Wang, Zhe,et al."Rubipodanones A-D, naphthohydroquinone dimers from rhizomes of &ITRubia podantha &IT".PHYTOCHEMISTRY 145(2018):153-160.
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