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题名: Rubipodanones A-D, naphthohydroquinone dimers from rhizomes of &ITRubia podantha &IT
作者: Wang, Zhe1, 2, 3; Zhao, Si-Meng3; Hu, Yan-Yun1, 2; Feng, Li1, 2; Zhao, Li-Mei3; Di, Ying-Tong3; Tan, Ning-Hua1, 2, 3
刊名: PHYTOCHEMISTRY
关键词: Rubia podantha ; Rubiaceae ; Naphthohydroquinone dimers ; Rubipodanones A-D ; Cytotoxicity ; NF-kappa B signaling pathway
英文摘要: Four previously undescribed naphthohydroquinone dimers named rubipodanones AD, together with 19 known quinones containing three known napthohydroquinone dimers named rubioncolin C, methyl 5-hydroxy-dinaphtho[1,2-2',3']furan-7,12-dione-6-carboxylate and rubialatin B, were isolated from the roots and rhizomes of Rubia podantha. Their structures and absolute configurations were determined mainly by NMR, X-ray diffraction, and computational methods. Rubipodanones C and D, the glycosides of rubipodanone A and a pair of C-3 epimer, are the first identified dimeric napthohydroquinone glycosides from the Rubia plants. All naphthohydroquinone dimers were evaluated for their cytotoxicities against ten tumor cell lines and effects on the tumor-associated NF-kappa B signaling pathway, and rubioncolin C showed the best cytotoxicity with IC50 value of 1.53 mu M and NF-kappa B inhibitory activity with IC50 value of 2.97 mu M. These results also demonstrated that the key roles of C-3 configuration and sugar group for biological activities of rubipodanone C. (C) 2017 Elsevier Ltd. All rights reserved.
出版日期: 2018
卷号: 145, 页码:153-160
DOI标识: 10.1016/j.phytochem.2017.11.002
语种: 英语
ISSN号: 0031-9422
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/60585
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.China Pharmaceut Univ, Sch Tradit Chinese Pharm, Nanjing 211198, Jiangsu, Peoples R China
2.China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 211198, Jiangsu, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Chi, Kunming 650201, Yunnan, Peoples R China

Recommended Citation:
Wang, Zhe,Zhao, Si-Meng,Hu, Yan-Yun,et al. Rubipodanones A-D, naphthohydroquinone dimers from rhizomes of &ITRubia podantha &IT[J]. PHYTOCHEMISTRY,2018,145:153-160.
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