| Cucurbitacin E Induces Cell Cycle G2/M Phase Arrest and Apoptosis in Triple Negative Breast Cancer | |
Kong, Yanjie1,3; Chen, Jianchao2; Zhou, Zhongmei1; Xia, Houjun1; Qiu, Ming-Hua2 ; Chen, Ceshi1; Qiu,MH (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming,Yunnan,Peoples R China.; qiuminghua@mail.kib.ac.cn; chenc@mail.kiz.ac.cn
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| 2014-07-29 | |
| 发表期刊 | PLOS ONE
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| ISSN | 1932-6203 |
| 卷号 | 9期号:7页码:e103760 |
| 摘要 | Triple negative breast cancer (TNBC) is a highly aggressive form of breast cancer resistant to many common treatments. In this study, we compared the effects of 12 phytochemical drugs on four cancer cell lines, and noticed that Cucurbitacin E (CuE) significantly inhibited TNBC cell growth by inducing cell cycle G2/M phase arrest and apoptosis. CuE reduced expression of Cyclin D1, Survivin, XIAP, Bcl2, and Mcl-1 in MDA-MB-468 and SW527, and within MDA-MB-468, CuE significantly increased activation of JNK and inhibited activation of AKT and ERK. Collectively, these results suggest that CuE may be a viable compound for developing novel TNBC therapeutics. |
| 关键词 | Inhibitory-activity Signaling Pathway Carcinoma Growth Activation |
| 学科领域 | Science & Technology - Other Topics |
| DOI | 10.1371/journal.pone.0103760 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000341307600085 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/18394 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Qiu,MH (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming,Yunnan,Peoples R China.; qiuminghua@mail.kib.ac.cn; chenc@mail.kiz.ac.cn |
| 作者单位 | 1.Chinese Acad Sci, Chinese Acad Sci & Yunnan Prov, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Kunming Coll Life Sci, Kunming, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Kong, Yanjie,Chen, Jianchao,Zhou, Zhongmei,et al. Cucurbitacin E Induces Cell Cycle G2/M Phase Arrest and Apoptosis in Triple Negative Breast Cancer[J]. PLOS ONE,2014,9(7):e103760. |
| APA | Kong, Yanjie.,Chen, Jianchao.,Zhou, Zhongmei.,Xia, Houjun.,Qiu, Ming-Hua.,...&chenc@mail.kiz.ac.cn.(2014).Cucurbitacin E Induces Cell Cycle G2/M Phase Arrest and Apoptosis in Triple Negative Breast Cancer.PLOS ONE,9(7),e103760. |
| MLA | Kong, Yanjie,et al."Cucurbitacin E Induces Cell Cycle G2/M Phase Arrest and Apoptosis in Triple Negative Breast Cancer".PLOS ONE 9.7(2014):e103760. |
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| Kong-2014-Cucurbitac（3184KB） | 开放获取 | CC BY-NC-SA | 浏览 下载 | |||
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