Cucurbitacin E Induces Cell Cycle G2/M Phase Arrest and Apoptosis in Triple Negative Breast Cancer
Kong, Yanjie1,3; Chen, Jianchao2; Zhou, Zhongmei1; Xia, Houjun1; Qiu, Ming-Hua2; Chen, Ceshi1; Qiu,MH (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming,Yunnan,Peoples R China.; qiuminghua@mail.kib.ac.cn; chenc@mail.kiz.ac.cn
2014-07-29
发表期刊PLOS ONE
ISSN1932-6203
卷号9期号:7页码:e103760
摘要Triple negative breast cancer (TNBC) is a highly aggressive form of breast cancer resistant to many common treatments. In this study, we compared the effects of 12 phytochemical drugs on four cancer cell lines, and noticed that Cucurbitacin E (CuE) significantly inhibited TNBC cell growth by inducing cell cycle G2/M phase arrest and apoptosis. CuE reduced expression of Cyclin D1, Survivin, XIAP, Bcl2, and Mcl-1 in MDA-MB-468 and SW527, and within MDA-MB-468, CuE significantly increased activation of JNK and inhibited activation of AKT and ERK. Collectively, these results suggest that CuE may be a viable compound for developing novel TNBC therapeutics.
关键词Inhibitory-activity Signaling Pathway Carcinoma Growth Activation
资助信息National Natural Science Foundation of China [81120108019, U1132605, 81325016, U1192604, 39970086]
收录类别SCI
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18394
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Qiu,MH (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming,Yunnan,Peoples R China.; qiuminghua@mail.kib.ac.cn; chenc@mail.kiz.ac.cn
作者单位1.Chinese Acad Sci, Chinese Acad Sci & Yunnan Prov, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
3.Univ Chinese Acad Sci, Kunming Coll Life Sci, Kunming, Yunnan, Peoples R China
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Kong, Yanjie,Chen, Jianchao,Zhou, Zhongmei,et al. Cucurbitacin E Induces Cell Cycle G2/M Phase Arrest and Apoptosis in Triple Negative Breast Cancer[J]. PLOS ONE,2014,9(7):e103760.
APA Kong, Yanjie.,Chen, Jianchao.,Zhou, Zhongmei.,Xia, Houjun.,Qiu, Ming-Hua.,...&chenc@mail.kiz.ac.cn.(2014).Cucurbitacin E Induces Cell Cycle G2/M Phase Arrest and Apoptosis in Triple Negative Breast Cancer.PLOS ONE,9(7),e103760.
MLA Kong, Yanjie,et al."Cucurbitacin E Induces Cell Cycle G2/M Phase Arrest and Apoptosis in Triple Negative Breast Cancer".PLOS ONE 9.7(2014):e103760.
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