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题名: Cucurbitacin E Induces Cell Cycle G2/M Phase Arrest and Apoptosis in Triple Negative Breast Cancer
作者: Kong, Yanjie1, 3; Chen, Jianchao2; Zhou, Zhongmei1; Xia, Houjun1; null(邱明华)2; Chen, Ceshi1
刊名: PLOS ONE
出版日期: 2014-07-29
卷号: 9, 期号:7, 页码:e103760
关键词: INHIBITORY-ACTIVITY ; SIGNALING PATHWAY ; CARCINOMA ; GROWTH ; ACTIVATION
学科分类: Science & Technology - Other Topics
DOI: 10.1371/journal.pone.0103760
通讯作者: Qiu,MH (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming,Yunnan,Peoples R China. ; qiuminghua@mail.kib.ac.cn ; chenc@mail.kiz.ac.cn
文章类型: Article
英文摘要: Triple negative breast cancer (TNBC) is a highly aggressive form of breast cancer resistant to many common treatments. In this study, we compared the effects of 12 phytochemical drugs on four cancer cell lines, and noticed that Cucurbitacin E (CuE) significantly inhibited TNBC cell growth by inducing cell cycle G2/M phase arrest and apoptosis. CuE reduced expression of Cyclin D1, Survivin, XIAP, Bcl2, and Mcl-1 in MDA-MB-468 and SW527, and within MDA-MB-468, CuE significantly increased activation of JNK and inhibited activation of AKT and ERK. Collectively, these results suggest that CuE may be a viable compound for developing novel TNBC therapeutics.
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: INHIBITORY-ACTIVITY ; SIGNALING PATHWAY ; CARCINOMA ; GROWTH ; ACTIVATION
收录类别: SCI
语种: 英语
WOS记录号: WOS:000341307600085
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/18394
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Chinese Acad Sci & Yunnan Prov, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
3.Univ Chinese Acad Sci, Kunming Coll Life Sci, Kunming, Yunnan, Peoples R China

Recommended Citation:
Kong,Yanjie;Chen,Jianchao;Zhou,Zhongmei;Xia,Houjun;Qiu,Ming-Hua;Chen,Ceshi.Cucurbitacin E Induces Cell Cycle G2/M Phase Arrest and Apoptosis in Triple Negative Breast Cancer,PLOS ONE,2014,9(7):e103760
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