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Acetyl-macrocalin B suppresses tumor growth in esophageal squamous cell carcinoma and exhibits synergistic anti-cancer effects with the Chk1/2 inhibitor AZD7762 期刊论文
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2019, 卷号: 365, 页码: 71-83
作者:  Wang, Jing-Nan;  Che, Yun;  Yuan, Zu-Yang;  Lu, Zhi-Liang;  Li, Yuan;  Zhang, Zhi-Rong;  Li, Ning;  Li, Ren-Da;  Wan, Jun;  Sun, Han-Dong;  Sun, Nan;  Puno, Pema-Tenzin;  He, Jie
浏览  |  Adobe PDF(3457Kb)  |  收藏  |  浏览/下载：350/77  |  提交时间：2019/03/18
Acetyl-macrocalin B  Reactive oxygen species  p38 MAPK  Chk1/Chk2  Esophageal squamous cell carcinoma  
Bioactive ent-kaurane diterpenoids from Isodon rubescens 期刊论文
PHYTOCHEMISTRY, 2017, 卷号: 143, 页码: 199-207
作者:  Zhang, Yuan-Yuan;  Jiang, Hua-Yi;  Liu, Miao;  Hu, Kun;  Wang, Wei-Guang;  Du, Xue;  Li, Xiao-Nian;  Pu, Jian-Xin;  Sun, Han-Dong
浏览  |  Adobe PDF(1170Kb)  |  收藏  |  浏览/下载：452/74  |  提交时间：2017/11/20
Isodon Rubescens  Lamiaceae  Cytotoxicity  7  Anti-inflammatory  20-epoxy-ent-kaurane Diterpenoids  
The Natural Diterpenoid Isoforretin A Inhibits Thioredoxin-1 and Triggers Potent ROS-Mediated Antitumor Effects 期刊论文
CANCER RESEARCH, 2017, 卷号: 77, 期号: 4, 页码: 926-936
作者:  Sun, Xiaoyan;  Wang, Weiguang;  Chen, Jiao;  Cai, Xueting;  Yang, Jie;  Yang, Yang;  Yan, Huaijiang;  Cheng, Xiaolan;  Ye, Juan;  Lu, Wuguang;  Hu, Chunping;  Sun, Handong;  Pu, Jianxin;  Cao, Peng
浏览  |  Adobe PDF(1370Kb)  |  收藏  |  浏览/下载：509/233  |  提交时间：2017/02/28
Natural products against hematological malignancies and identification of their targets 期刊论文
SCIENCE CHINA-LIFE SCIENCES, 2015, 卷号: 58, 期号: 12, 页码: 1191-1201
作者:  Xu Ying;  Liu JinBao;  Wu YingLi;  Guo QingLong;  Sun HanDong;  Chen GuoQiang
Adobe PDF(756Kb)  |  收藏  |  浏览/下载：214/33  |  提交时间：2016/05/04
Natural Products  Adenanthin  Hematological Malignancies  Target Identification  
Xerophilusin B Induces Cell Cycle Arrest and Apoptosis in Esophageal Squamous Cell Carcinoma Cells and Does Not Cause Toxicity in Nude Mice 期刊论文
JOURNAL OF NATURAL PRODUCTS, 2015, 卷号: 78, 期号: 1, 页码: 10-16
作者:  Yao, Ran;  Chen, Zhaoli;  Zhou, Chengcheng;  Luo, Mei;  Shi, Xuejiao;  Li, Jiagen;  Gao, Yibo;  Zhou, Fang;  Pu, Jianxin;  Sun, Handong;  He, Jie
Adobe PDF(6589Kb)  |  收藏  |  浏览/下载：343/63  |  提交时间：2015/06/29
Peroxiredoxin-1 protects estrogen receptor alpha from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer 期刊论文
BREAST CANCER RESEARCH, 2014, 卷号: 16, 期号: 4, 页码: 8220-8224
作者:  O'Leary, Patrick C.;  Terrile, Marta;  Bajor, Malgorzata;  Gaj, Pawel;  Hennessy, Bryan T.;  Mills, Gordon B.;  Zagozdzon, Agnieszka;  O'Connor, Darran P.;  Brennan, Donal J.;  Connor, Kate;  Li, Jane;  Gonzalez-Angulo, Ana Maria;  Sun, Han-Dong;  Pu, Jian-Xin;  Ponten, Fredrik;  Uhlen, Mathias;  Jirstrom, Karin;  Nowis, Dominika A.;  Crown, John P.;  Zagozdzon, Radoslaw;  Gallagher, William M.;  Zagozdzon,R (reprint author),UCD Sch Biomol & Biomed Sci,UCD Conway Inst,Canc Biol & Therapeut Lab,Dublin 4,Ireland.;  radoslaw.zagozdzon@wum.edu.pl;  william.gallagher@ucd.ie
Adobe PDF(2561Kb)  |  收藏  |  浏览/下载：231/71  |  提交时间：2015/01/20
Natural-products  Roots  Secretion  Norsesquiterpenoids  Norbisabolane  Pyrimidine  
Anti-tumour activity of longikaurin A (LK-A), a novel natural diterpenoid, in nasopharyngeal carcinoma 期刊论文
JOURNAL OF TRANSLATIONAL MEDICINE, 2013, 卷号: 11, 期号: 1, 页码: 200
作者:  Zou, Qing-Feng;  Du, Ji-Ke;  Zhang, Hua;  Wang, Hong-Bo;  Hu, Ze-Dong;  Chen, Shu-Peng;  Du, Yong;  Li, Man-Zhi;  Xie, Dan;  Zou, Juan;  Sun, Han-Dong;  Pu, Jian-Xin;  Zeng, Mu-Sheng
Adobe PDF(3788Kb)  |  收藏  |  浏览/下载：322/54  |  提交时间：2013/10/16
Longikaurin a (Lk-a)  Apoptosis  Caspase  Nasopharyngeal Carcinoma  
Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways 期刊论文
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2012, 卷号: 262, 期号: 1, 页码: 80-90
作者:  Li, Lin;  Yue, Grace G. L.;  Lau, Clara B. S.;  Sun, Handong;  Fung, Kwok Pui;  Leung, Ping Chung;  Han, Quanbin;  Leung, Po Sing
Adobe PDF(2066Kb)  |  收藏  |  浏览/下载：332/67  |  提交时间：2014/04/02
Eriocalyxin b  Pancreatic Cancer  Apoptosis  Cell Cycle Arrest  P53  
Quick identification of apoptosis inducer from Isodon eriocalyx by a drug discovery platform composed of analytical high-speed counter-current chromatography and the fluorescence-based caspase-3 biosensor detection 期刊论文
TALANTA, 2010, 卷号: 82, 期号: 4, 页码: 1521-1527
作者:  Han, Quan-Bin;  Yu, Ting;  Lai, Fanny;  Zhou, Yan;  Feng, Chao;  Wang, Wei-Na;  Fu, Xiao-Hui;  Lau, Clara Bik-San;  Luo, Kathy Q.;  Xu, Hong-Xi;  Sun, Han-Dong;  Fung, Kwok-Pui;  Leung, Ping-Chung
Adobe PDF(487Kb)  |  收藏  |  浏览/下载：379/146  |  提交时间：2012/03/21
Analytical High-speed Counter-current Chromatography  Caspase-3 Biosensor  Isodon Eriocalyx  Apoptosis Inducer  Eriocalyxin b  
Isolation of two bioactive ent-Kauranoids from the leaves of Isodon xerophilus 期刊论文
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2007, 卷号: 55, 期号: 15, 页码: 6039-6043
作者:  Weng, Zhi-Ying;  Huang, Sheng-Xiong;  Li, Ma-Lin;  Zeng, Yue-Qin;  Han, Quan-Bin;  Rios, Jose Luis;  Sun, Han-Dong
Adobe PDF(93Kb)  |  收藏  |  浏览/下载：407/134  |  提交时间：2012/10/12
Anti-inflammation  Cytotoxicity  Herbal Tea  Isodon Xerophilus  Ent-kaurene Diterpenoid