| Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways | |
Li, Lin1,2,3; Yue, Grace G. L.1,3; Lau, Clara B. S.1,3; Sun, Handong4 ; Fung, Kwok Pui1,2,3; Leung, Ping Chung1,3; Han, Quanbin1,3,5; Leung, Po Sing2
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| 通讯作者 | Han, QB (reprint author), Chinese Univ Hong Kong, Inst Chinese Med, Hong Kong, Hong Kong, Peoples R China,simonhan@hkbu.edu.hk ; psleung@cuhk.edu.hk |
| 2012-07-01 | |
| 发表期刊 | TOXICOLOGY AND APPLIED PHARMACOLOGY
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| ISSN | 0041-008X |
| 卷号 | 262期号:1页码:80-90 |
| 摘要 | Pancreatic cancer is difficult to detect early and responds poorly to chemotherapy. A breakthrough in the development of new therapeutic agents is urgently needed. Eriocalyxin B (EriB), isolated from the Isodon eriocalyx plant, is an ent-kaurane diterpenoid with promise as a broad-spectrum anti-cancer agent. The anti-leukemic activity of EriB, including the underlying mechanisms involved, has been particularly well documented. In this study, we demonstrated for the first time EriB's potent cytotoxicity against four pancreatic adenocarcinoma cell lines, namely PANC-1, SW1990, CAPAN-1, and CAPAN-2. The effects were comparable to that of the chemotherapeutic camptothecin (CAM), but with much lower toxicity against normal human liver WRL68 cells. EriB's cytoxicity against CAPAN-2 cells was found to involve caspase-dependent apoptosis and cell cycle arrest at the G2/M phase. Moreover, the p53 pathway was found to be activated by EriB in these cells. Furthermore, in vivo studies showed that EriB inhibited the growth of human pancreatic tumor xenografts in BALB/c nude mice without significant secondary adverse effects. These results suggest that EriB should be considered a candidate for pancreatic cancer treatment. (C) 2012 Elsevier Inc. All rights reserved. |
| 关键词 | Eriocalyxin b Pancreatic Cancer Apoptosis Cell Cycle Arrest P53 |
| 学科领域 | Pharmacology & Pharmacy ; Toxicology |
| DOI | 10.1016/j.taap.2012.04.021 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000305382200009 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/17616 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Univ Hong Kong, Inst Chinese Med, Hong Kong, Hong Kong, Peoples R China 2.Chinese Univ Hong Kong, Sch Biomed Sci, Hong Kong, Hong Kong, Peoples R China 3.Chinese Univ Hong Kong, State Key Lab Phytochem & Plant Resources W China, Hong Kong, Hong Kong, Peoples R China 4.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming, Yunnan, Peoples R China 5.Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong, Hong Kong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Lin,Yue, Grace G. L.,Lau, Clara B. S.,et al. Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways[J]. TOXICOLOGY AND APPLIED PHARMACOLOGY,2012,262(1):80-90. |
| APA | Li, Lin.,Yue, Grace G. L..,Lau, Clara B. S..,Sun, Handong.,Fung, Kwok Pui.,...&Leung, Po Sing.(2012).Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways.TOXICOLOGY AND APPLIED PHARMACOLOGY,262(1),80-90. |
| MLA | Li, Lin,et al."Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways".TOXICOLOGY AND APPLIED PHARMACOLOGY 262.1(2012):80-90. |
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