Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways
Li, Lin1,2,3; Yue, Grace G. L.1,3; Lau, Clara B. S.1,3; Sun, Handong4; Fung, Kwok Pui1,2,3; Leung, Ping Chung1,3; Han, Quanbin1,3,5; Leung, Po Sing2
2012-07-01
发表期刊TOXICOLOGY AND APPLIED PHARMACOLOGY
ISSN0041-008X
卷号262期号:1页码:80-90
摘要Pancreatic cancer is difficult to detect early and responds poorly to chemotherapy. A breakthrough in the development of new therapeutic agents is urgently needed. Eriocalyxin B (EriB), isolated from the Isodon eriocalyx plant, is an ent-kaurane diterpenoid with promise as a broad-spectrum anti-cancer agent. The anti-leukemic activity of EriB, including the underlying mechanisms involved, has been particularly well documented. In this study, we demonstrated for the first time EriB's potent cytotoxicity against four pancreatic adenocarcinoma cell lines, namely PANC-1, SW1990, CAPAN-1, and CAPAN-2. The effects were comparable to that of the chemotherapeutic camptothecin (CAM), but with much lower toxicity against normal human liver WRL68 cells. EriB's cytoxicity against CAPAN-2 cells was found to involve caspase-dependent apoptosis and cell cycle arrest at the G2/M phase. Moreover, the p53 pathway was found to be activated by EriB in these cells. Furthermore, in vivo studies showed that EriB inhibited the growth of human pancreatic tumor xenografts in BALB/c nude mice without significant secondary adverse effects. These results suggest that EriB should be considered a candidate for pancreatic cancer treatment. (C) 2012 Elsevier Inc. All rights reserved.
关键词Eriocalyxin b Pancreatic Cancer Apoptosis Cell Cycle Arrest P53
学科领域Pharmacology & Pharmacy ; Toxicology
DOI10.1016/j.taap.2012.04.021
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy ; Toxicology
WOS类目Pharmacology & Pharmacy ; Toxicology
WOS记录号WOS:000305382200009
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/17616
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Univ Hong Kong, Inst Chinese Med, Hong Kong, Hong Kong, Peoples R China
2.Chinese Univ Hong Kong, Sch Biomed Sci, Hong Kong, Hong Kong, Peoples R China
3.Chinese Univ Hong Kong, State Key Lab Phytochem & Plant Resources W China, Hong Kong, Hong Kong, Peoples R China
4.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming, Yunnan, Peoples R China
5.Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong, Hong Kong, Peoples R China
推荐引用方式
GB/T 7714
Li, Lin,Yue, Grace G. L.,Lau, Clara B. S.,et al. Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways[J]. TOXICOLOGY AND APPLIED PHARMACOLOGY,2012,262(1):80-90.
APA Li, Lin.,Yue, Grace G. L..,Lau, Clara B. S..,Sun, Handong.,Fung, Kwok Pui.,...&Leung, Po Sing.(2012).Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways.TOXICOLOGY AND APPLIED PHARMACOLOGY,262(1),80-90.
MLA Li, Lin,et al."Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways".TOXICOLOGY AND APPLIED PHARMACOLOGY 262.1(2012):80-90.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Li-2012-Eriocalyxin (2066KB) 开放获取CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, Lin]的文章
[Yue, Grace G. L.]的文章
[Lau, Clara B. S.]的文章
百度学术
百度学术中相似的文章
[Li, Lin]的文章
[Yue, Grace G. L.]的文章
[Lau, Clara B. S.]的文章
必应学术
必应学术中相似的文章
[Li, Lin]的文章
[Yue, Grace G. L.]的文章
[Lau, Clara B. S.]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。