Natural products against hematological malignancies and identification of their targets

doi:10.1007/s11427-015-4922-4

	Natural products against hematological malignancies and identification of their targets
	Xu Ying 1,2; Liu JinBao 3; Wu YingLi 1; Guo QingLong 4; Sun HanDong5 ; Chen GuoQiang 1,2
	2015-12-01
发表期刊	SCIENCE CHINA-LIFE SCIENCES
卷号	58 期号:12 页码:1191-1201
摘要	Naturally occurring molecules derived from higher plants, animals, microorganisms and minerals play an important role in the discovery and development of novel therapeutic agents. The identification of molecular targets is of interest to elucidate the mode of action of these compounds, and it may be employed to set up target-based assays and allow structure-activity relationship studies to guide medicinal chemistry efforts toward lead optimization. In recent years, plant-derived natural compounds possessing potential anti-tumor activities have been garnering much interest and efforts are underway to identify their molecular targets. Here, we attempt to summarize the discoveries of several natural compounds with activities against hematological malignancies, such as adenanthin, oridonin, gambogic acid and wogonoside, the identification of their targets, and their modes of actions.
关键词	Natural Products Adenanthin Hematological Malignancies Target Identification
DOI	10.1007/s11427-015-4922-4
收录类别	SCI
语种	英语
WOS记录号	WOS:000368529300002
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/25455
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Shanghai Jiao Tong Univ, Sch Med,Shanghai Univ E Inst, Dept Pathophysiol,Minist Educ, Chem Biol Div,Key Lab Cell Differentiat & Apoptos, Shanghai 200025, Peoples R China 2.Shanghai Jiao Tong Univ, Chinese Acad Sci, Sch Med, Inst Hlth Sci,Shanghai Inst Biol Sci, Shanghai 200025, Peoples R China 3.Guangzhou Med Univ, State Key Lab Resp Dis, Prot Modificat & Degradat Lab, Dept Pathophysiol, Guangzhou 510182, Guangdong, Peoples R China 4.China Pharmaceut Univ, State Key Lab Nat Med, Jiangsu Key Lab Carcinogenesis & Intervent, Nanjing 211198, Jiangsu, Peoples R China 5.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Peoples R China
推荐引用方式 GB/T 7714	Xu Ying,Liu JinBao,Wu YingLi,et al. Natural products against hematological malignancies and identification of their targets[J]. SCIENCE CHINA-LIFE SCIENCES,2015,58(12):1191-1201.
APA	Xu Ying,Liu JinBao,Wu YingLi,Guo QingLong,Sun HanDong,&Chen GuoQiang.(2015).Natural products against hematological malignancies and identification of their targets.SCIENCE CHINA-LIFE SCIENCES,58(12),1191-1201.
MLA	Xu Ying,et al."Natural products against hematological malignancies and identification of their targets".SCIENCE CHINA-LIFE SCIENCES 58.12(2015):1191-1201.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
art%3A10.1007%2Fs114（756KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览下载