| Bioactive ent-kaurane diterpenoids from Isodon rubescens | |
Zhang, Yuan-Yuan1,2,3; Jiang, Hua-Yi1,3; Liu, Miao1,3; Hu, Kun1,3 ; Wang, Wei-Guang1,3; Du, Xue1,3; Li, Xiao-Nian1,3; Pu, Jian-Xin1,3; Sun, Han-Dong1,3
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| 2017-11-01 | |
| 发表期刊 | PHYTOCHEMISTRY
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| ISSN | 0031-9422 |
| 卷号 | 143页码:199-207 |
| 摘要 | Seven previously undescribed 7,20-epoxy-ent-kaurane diterpenoids, isojiangrubesins A-G, along with seventeen known ones, were isolated from the aerial parts of Isodon rubescens. Their structures were characterized on the basis of spectroscopic methods and signal-crystal X-ray diffraction. All of these compounds were evaluated for their in vitro cytotoxicity against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480). Four isolates exhibited significant inhibitory ability against all cell lines, with IC50 values ranging from 0.5 to 6.5 AM; They also strongly inhibited NO production in LPS-stimulated RAW264.7 cells. (C) 2017 Published by Elsevier Ltd. |
| 关键词 | Isodon Rubescens Lamiaceae Cytotoxicity 7 Anti-inflammatory 20-epoxy-ent-kaurane Diterpenoids |
| DOI | 10.1016/j.phytochem.2017.08.009 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000413128900025 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/54989 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 10039, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Yuan-Yuan,Jiang, Hua-Yi,Liu, Miao,et al. Bioactive ent-kaurane diterpenoids from Isodon rubescens[J]. PHYTOCHEMISTRY,2017,143:199-207. |
| APA | Zhang, Yuan-Yuan.,Jiang, Hua-Yi.,Liu, Miao.,Hu, Kun.,Wang, Wei-Guang.,...&Sun, Han-Dong.(2017).Bioactive ent-kaurane diterpenoids from Isodon rubescens.PHYTOCHEMISTRY,143,199-207. |
| MLA | Zhang, Yuan-Yuan,et al."Bioactive ent-kaurane diterpenoids from Isodon rubescens".PHYTOCHEMISTRY 143(2017):199-207. |
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| 19.pdf（1170KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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