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题名: Bioactive ent-kaurane diterpenoids from Isodon rubescens
作者: Zhang, Yuan-Yuan1, 2, 3; Jiang, Hua-Yi1, 3; Liu, Miao1, 3; Hu, Kun1, 3; Wang, Wei-Guang1, 3; Du, Xue1, 3; Li, Xiao-Nian1, 3; Pu, Jian-Xin1, 3; Sun, Han-Dong1, 3
刊名: PHYTOCHEMISTRY
关键词: Isodon rubescens ; Lamiaceae ; 7,20-Epoxy-ent-kaurane diterpenoids ; Cytotoxicity ; Anti-inflammatory
英文摘要: Seven previously undescribed 7,20-epoxy-ent-kaurane diterpenoids, isojiangrubesins A-G, along with seventeen known ones, were isolated from the aerial parts of Isodon rubescens. Their structures were characterized on the basis of spectroscopic methods and signal-crystal X-ray diffraction. All of these compounds were evaluated for their in vitro cytotoxicity against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480). Four isolates exhibited significant inhibitory ability against all cell lines, with IC50 values ranging from 0.5 to 6.5 AM; They also strongly inhibited NO production in LPS-stimulated RAW264.7 cells. (C) 2017 Published by Elsevier Ltd.
出版日期: 2017-11-01
卷号: 143, 页码:199-207
DOI标识: 10.1016/j.phytochem.2017.08.009
语种: 英语
ISSN号: 0031-9422
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/54989
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 10039, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China

Recommended Citation:
Yuan-Yuan Zhang;Hua-Yi Jiang;Miao Liu;Kun Hu; Wei-Guang Wang;Xue Du;Xiao-Nian Li;Jian-Xin Pu;Han-Dong Sun. Bioactive ent-Kaurane Diterpenoids from Isodon rubescens[J]. Phytochemistry,2017,143:199e207.
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