Bioactive ent-kaurane diterpenoids from Isodon rubescens
Zhang, Yuan-Yuan1,2,3; Jiang, Hua-Yi1,3; Liu, Miao1,3; Hu, Kun1,3; Wang, Wei-Guang1,3; Du, Xue1,3; Li, Xiao-Nian1,3; Pu, Jian-Xin1,3; Sun, Han-Dong1,3
2017-11-01
发表期刊PHYTOCHEMISTRY
ISSN0031-9422
卷号143页码:199-207
摘要Seven previously undescribed 7,20-epoxy-ent-kaurane diterpenoids, isojiangrubesins A-G, along with seventeen known ones, were isolated from the aerial parts of Isodon rubescens. Their structures were characterized on the basis of spectroscopic methods and signal-crystal X-ray diffraction. All of these compounds were evaluated for their in vitro cytotoxicity against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480). Four isolates exhibited significant inhibitory ability against all cell lines, with IC50 values ranging from 0.5 to 6.5 AM; They also strongly inhibited NO production in LPS-stimulated RAW264.7 cells. (C) 2017 Published by Elsevier Ltd.
关键词Isodon Rubescens Lamiaceae Cytotoxicity 7 Anti-inflammatory 20-epoxy-ent-kaurane Diterpenoids
DOI10.1016/j.phytochem.2017.08.009
收录类别SCI
语种英语
WOS记录号WOS:000413128900025
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/54989
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 10039, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
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Zhang, Yuan-Yuan,Jiang, Hua-Yi,Liu, Miao,et al. Bioactive ent-kaurane diterpenoids from Isodon rubescens[J]. PHYTOCHEMISTRY,2017,143:199-207.
APA Zhang, Yuan-Yuan.,Jiang, Hua-Yi.,Liu, Miao.,Hu, Kun.,Wang, Wei-Guang.,...&Sun, Han-Dong.(2017).Bioactive ent-kaurane diterpenoids from Isodon rubescens.PHYTOCHEMISTRY,143,199-207.
MLA Zhang, Yuan-Yuan,et al."Bioactive ent-kaurane diterpenoids from Isodon rubescens".PHYTOCHEMISTRY 143(2017):199-207.
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