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High throughput-screening of native herbal compounds identifies taccaoside A as a cytotoxic compound that mediates RAS signaling in cancer stem cells 期刊论文
PHYTOMEDICINE, 2023, 卷号: 108, 页码: 154492
作者:  Yang,Dong;  Dai,Zhi;  Zhu,Peifeng;  Wang,Gan;  Sun,Bin;  Li,Shirong;  Hao,Junjun;  Wang,Yifen;  Liu,Yaping;  Yu,Shuaishuai;  Lai,Ren;  Luo,Xiao-Dong;  Zhao,Xudong
浏览  |  Adobe PDF(6987Kb)  |  收藏  |  浏览/下载：1/1  |  提交时间：2024/07/17
Natural product  Furostanol saponin  Taccaoside A  Cancer stem cell  RAS  STEROIDAL SAPONINS  NATURAL-PRODUCTS  PI3K/AKT  PROLIFERATION  MAINTENANCE  STATISTICS  MAPK/ERK  
Neothalfine, a potent natural anti-tumor agent against metastatic colorectal cancer and its primary mechanism 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 29, 页码: 115849
作者:  Zhu,Yan-Yan;  Jin,Qiong;  Chen,Shan-Shan;  Jin,Dan-Ni;  Wang,Zhao-Jie;  He,Ying-Jie;  Chen,Hui-Cheng;  Zhao,Yun-Li;  Zhao,Li-Xing;  Dai,Zhi;  Luo,Xiao-Dong
浏览  |  Adobe PDF(2120Kb)  |  收藏  |  浏览/下载：213/48  |  提交时间：2022/04/02
Neothalfine  Bisbenzylisoquinoline alkaloid  Metastatic colorectal cancer  Metabolomic  Mitochondrial apoptosis  SMALL MOLECULES  IRINOTECAN  RESISTANCE  CELL  IMMUNOTHERAPY  OPPORTUNITIES  CHEMOTHERAPY  VINORELBINE  ALKALOIDS  PATHWAY  
Structures/cytotoxicity/selectivity relationship of natural steroidal saponins against GSCs and primary mechanism of tribulosaponin A 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 210, 页码: 113068
作者:  Dai,Zhi;  Liu,Hui;  Wang,Bei;  Yang,Dong;  Zhu,Yan-Yan;  Yan,Huan;  Zhu,Pei-Feng;  Liu,Ya-Ping;  Chen,Hui-Cheng;  Zhao,Yun-li;  Zhao,Li-Xing;  Zhao,Xu-Dong;  Liu,Hai-Yang;  Luo,Xiao-Dong
浏览  |  Adobe PDF(2630Kb)  |  收藏  |  浏览/下载：168/86  |  提交时间：2022/04/02
Steroidal saponins  Structure-activity relationship  Tribulosaponin A  Glioma stem cells  ROS  SMALL MOLECULES  CARDIAC-ARREST  STEM-CELL  IDENTIFICATION  THERAPY  BRAIN  OPPORTUNITIES  GLIOMA  TUMORS  NOX2  
New aporphine alkaloids with selective cytotoxicity against glioma stem cells from Thalictrum foetidum 期刊论文
CHINESE JOURNAL OF NATURAL MEDICINES, 2019, 卷号: 17, 期号: 9, 页码: 698-706
作者:  Ding Cai-Feng;  Dai Zhi;  Yu Hao-Fei;  Zhao Xu-Dong;  Luo Xiao-Dong
浏览  |  Adobe PDF(3366Kb)  |  收藏  |  浏览/下载：201/79  |  提交时间：2019/10/28
Thalictrum foetidum  Aporphine alkaloids  Selective cytotoxicity  Glioma stem cells  
Novel nor-monoterpenoid indole alkaloids inhibiting glioma stem cells from fruits of Alstonia scholaris 期刊论文
PHYTOMEDICINE, 2018, 卷号: 48, 页码: 170-178
作者:  Wang, Bei;  Dai, Zhi;  Yang, Xiong-Wu;  Liu, Ya-Ping;  Khan, Afsar;  Yang, Zi-Feng;  Huang, Wan-Yi;  Wang, Xin-Hua;  Zhao, Xu-Dong;  Luo, Xiao-Dong
收藏  |  浏览/下载：216/0  |  提交时间：2018/10/04
Glioma stem cells  Antitumor activity  Alstonia scholaris  Nor-monoterpenoid indole alkaloids  
Isocostunolide inhibited glioma stem cell by suppression proliferation and inducing caspase dependent apoptosis 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 页码: 2863-2867
作者:  Dai, Zhi;  Li, Shi-Rong;  Zhu, Pei-Feng;  Liu, Lu;  Wang, Bei;  Liu, Ya-Ping;  Luo, Xiao-Dong;  Zhao, Xu-Dong
浏览  |  Adobe PDF(2209Kb)  |  收藏  |  浏览/下载：296/66  |  提交时间：2017/07/18
Isocostunolide  Glioma Stem Cells  Cell Proliferation  Apoptosis  Colony Formation  
Cytotoxic Indole Alkaloid 3 alpha-Acetonyltabersonine Induces Glioblastoma Apoptosis via Inhibition of DNA Damage Repair 期刊论文
TOXINS, 2017, 卷号: 9, 期号: 5, 页码: 150
作者:  Li, Yuan;  Zhao, Yunli;  Zhou, Xia;  Ni, Wei;  Dai, Zhi;  Yang, Dong;  Hao, Junjun;  Luo, Lin;  Liu, Yaping;  Luo, Xiaodong;  Zhao, Xudong
浏览  |  Adobe PDF(3339Kb)  |  收藏  |  浏览/下载：217/49  |  提交时间：2017/07/31
Melodinus Suaveolens  Indole Alkaloid  3 Alpha-acetonyltabersonine  Glioblastoma  Cell Apoptosis  Dna Damage Repair  
Three New Pyridine Alkaloids from Vinca major Cultivated in Pakistan. 期刊论文
Natural products and bioprospecting, 2017, 卷号: 7, 期号: 4, 页码: 323-327
作者:  Wei, Xin;  Khan, Afsar;  Song, Da;  Dai, Zhi;  Liu, Ya-Ping;  Yu, Hao-Fei;  Wang, Bei;  Zhu, Pei-Feng;  Ding, Cai-Feng;  Zhao, Xu-Dong;  Wang, Yi-Fen;  Luo, Xiao-Dong
收藏  |  浏览/下载：75/0  |  提交时间：2019/03/29
Neoalbaconol induces energy depletion and multiple cell death in cancer cells by targeting PDK1-PI3-K/Akt signaling pathway 期刊论文
CELL DEATH & DISEASE, 2013, 卷号: 4, 页码: e804
作者:  Deng, Q.;  Yu, X.;  Xiao, L.;  Hu, Z.;  Luo, X.;  Tao, Y.;  Yang, L.;  Liu, X.;  Chen, H.;  Ding, Z.;  Feng, T.;  Tang, Y.;  Weng, X.;  Gao, J.;  Yi, W.;  Bode, A. M.;  Dong, Z.;  Liu, J.;  Cao, Y.
Adobe PDF(1755Kb)  |  收藏  |  浏览/下载：630/73  |  提交时间：2013/11/12
Neoalbaconol  Pdk1  Pi3-k/akt  Energy Depletion  Cancer Cell Death  
Meliaceous Limonoids: Chemistry and Biological Activities 期刊论文
CHEMICAL REVIEWS, 2011, 卷号: 111, 期号: 11, 页码: 7437-7522
作者:  Tan, Qin-Gang;  Luo, Xiao-Dong
Adobe PDF(8269Kb)  |  收藏  |  浏览/下载：1286/403  |  提交时间：2012/04/10
Mangrove Xylocarpus-granatum  Azadirachta-indica Juss  West African Timbers  A.  Performance Liquid-chromatography  Var-japonica-makino  C-seco Limonoids  Insect Antifeedant Azadirachtin  Swietenia-mahagoni Jacq  Chisocheton-paniculatus Hiern  Khaya-senegalensis Meliaceae