New aporphine alkaloids with selective cytotoxicity against glioma stem cells from Thalictrum foetidum
Ding Cai-Feng1,6; Dai Zhi1; Yu Hao-Fei1,4,5; Zhao Xu-Dong2; Luo Xiao-Dong1,3
Corresponding AuthorZhao Xu-Dong(zhaoxudong@mail.kiz.ac.cn) ; Luo Xiao-Dong(xdluo@mail.kib.ac.cn)
2019-09-01
Source PublicationCHINESE JOURNAL OF NATURAL MEDICINES
ISSN2095-6975
Volume17Issue:9Pages:698-706
AbstractSeven new isoquinoline alkaloids, 9-(2'-formyl-5', 6 '-dimethoxyphenoxy)-1, 2, 3, 10-tetramethoxy dehydroaporphine (1), 9-(2'-formyl-5, 6'-dimethoxyphenoxy)-1, 2, 3, 10-tetramethoxy oxoaporphine (2), 3-methoxy-2'-formyl oxohemandalin (3), (-)-9-(2'-methoxycarbonyl-5', 6 '-dimethoxyphenoxy)-1, 2, 3, 10-tetramethoxy aporphine (4), (-)-2'-methoxycarbonyl thaliadin (5), (-)-9-(2'-methoxyethy1-5', 6'-dimethoxyphenoxy)-1, 2, 3, 10-tetramethoxy aporphine (6), (-)-3-methoxy hydroxyhemandalinol (7), together with six known isoquinoline alkaloids (8-13) were isolated from the roots of Thalictrum foetidum. Their structures were elucidated by extensive spectroscopic measurements. Compounds 1 and 2 showed significant selective cytotoxicity against glioma stem cells (GSC-3(#) and GSC-18(#) ) with IC50 values ranging from 2.36 to 5.37 mu g.mL(-1).
KeywordThalictrum foetidum Aporphine alkaloids Selective cytotoxicity Glioma stem cells
Indexed BySCI
Language英语
WOS IDWOS:000485870100007
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/68651
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorZhao Xu-Dong; Luo Xiao-Dong
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, Key Lab Phytochem & Plant Resources West China, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Zool, Key Lab Bioact Peptides Yunnan Prov, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China
3.Yunnan Univ, Sch Chem Sci & Technol, Minist Educ & Yunnan Prov, Key Lab Med Chem Nat Resource, Kunming 650091, Yunnan, Peoples R China
4.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Yunnan, Peoples R China
5.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Yunnan, Peoples R China
6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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GB/T 7714
Ding Cai-Feng,Dai Zhi,Yu Hao-Fei,et al. New aporphine alkaloids with selective cytotoxicity against glioma stem cells from Thalictrum foetidum[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2019,17(9):698-706.
APA Ding Cai-Feng,Dai Zhi,Yu Hao-Fei,Zhao Xu-Dong,&Luo Xiao-Dong.(2019).New aporphine alkaloids with selective cytotoxicity against glioma stem cells from Thalictrum foetidum.CHINESE JOURNAL OF NATURAL MEDICINES,17(9),698-706.
MLA Ding Cai-Feng,et al."New aporphine alkaloids with selective cytotoxicity against glioma stem cells from Thalictrum foetidum".CHINESE JOURNAL OF NATURAL MEDICINES 17.9(2019):698-706.
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