New aporphine alkaloids with selective cytotoxicity against glioma stem cells from Thalictrum foetidum

	New aporphine alkaloids with selective cytotoxicity against glioma stem cells from Thalictrum foetidum
	Ding Cai-Feng1,6 ; Dai Zhi 1; Yu Hao-Fei 1,4,5; Zhao Xu-Dong 2; Luo Xiao-Dong1,3
通讯作者	Zhao Xu-Dong(zhaoxudong@mail.kiz.ac.cn) ; Luo Xiao-Dong(xdluo@mail.kib.ac.cn)
	2019-09-01
发表期刊	CHINESE JOURNAL OF NATURAL MEDICINES
ISSN	2095-6975
卷号	17 期号:9 页码:698-706
摘要	Seven new isoquinoline alkaloids, 9-(2'-formyl-5', 6 '-dimethoxyphenoxy)-1, 2, 3, 10-tetramethoxy dehydroaporphine (1), 9-(2'-formyl-5, 6'-dimethoxyphenoxy)-1, 2, 3, 10-tetramethoxy oxoaporphine (2), 3-methoxy-2'-formyl oxohemandalin (3), (-)-9-(2'-methoxycarbonyl-5', 6 '-dimethoxyphenoxy)-1, 2, 3, 10-tetramethoxy aporphine (4), (-)-2'-methoxycarbonyl thaliadin (5), (-)-9-(2'-methoxyethy1-5', 6'-dimethoxyphenoxy)-1, 2, 3, 10-tetramethoxy aporphine (6), (-)-3-methoxy hydroxyhemandalinol (7), together with six known isoquinoline alkaloids (8-13) were isolated from the roots of Thalictrum foetidum. Their structures were elucidated by extensive spectroscopic measurements. Compounds 1 and 2 showed significant selective cytotoxicity against glioma stem cells (GSC-3(#) and GSC-18(#) ) with IC50 values ranging from 2.36 to 5.37 mu g.mL(-1).
关键词	Thalictrum foetidum Aporphine alkaloids Selective cytotoxicity Glioma stem cells
收录类别	SCI
语种	英语
WOS记录号	WOS:000485870100007
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/68651
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Zhao Xu-Dong; Luo Xiao-Dong
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, Key Lab Phytochem & Plant Resources West China, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Zool, Key Lab Bioact Peptides Yunnan Prov, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China 3.Yunnan Univ, Sch Chem Sci & Technol, Minist Educ & Yunnan Prov, Key Lab Med Chem Nat Resource, Kunming 650091, Yunnan, Peoples R China 4.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Yunnan, Peoples R China 5.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Yunnan, Peoples R China 6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Ding Cai-Feng,Dai Zhi,Yu Hao-Fei,et al. New aporphine alkaloids with selective cytotoxicity against glioma stem cells from Thalictrum foetidum[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2019,17(9):698-706.
APA	Ding Cai-Feng,Dai Zhi,Yu Hao-Fei,Zhao Xu-Dong,&Luo Xiao-Dong.(2019).New aporphine alkaloids with selective cytotoxicity against glioma stem cells from Thalictrum foetidum.CHINESE JOURNAL OF NATURAL MEDICINES,17(9),698-706.
MLA	Ding Cai-Feng,et al."New aporphine alkaloids with selective cytotoxicity against glioma stem cells from Thalictrum foetidum".CHINESE JOURNAL OF NATURAL MEDICINES 17.9(2019):698-706.

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