| New aporphine alkaloids with selective cytotoxicity against glioma stem cells from Thalictrum foetidum | |
Ding Cai-Feng1,6 ; Dai Zhi1; Yu Hao-Fei1,4,5; Zhao Xu-Dong2; Luo Xiao-Dong1,3
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| 通讯作者 | Zhao Xu-Dong(zhaoxudong@mail.kiz.ac.cn) ; Luo Xiao-Dong(xdluo@mail.kib.ac.cn) |
| 2019-09-01 | |
| 发表期刊 | CHINESE JOURNAL OF NATURAL MEDICINES
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| ISSN | 2095-6975 |
| 卷号 | 17期号:9页码:698-706 |
| 摘要 | Seven new isoquinoline alkaloids, 9-(2'-formyl-5', 6 '-dimethoxyphenoxy)-1, 2, 3, 10-tetramethoxy dehydroaporphine (1), 9-(2'-formyl-5, 6'-dimethoxyphenoxy)-1, 2, 3, 10-tetramethoxy oxoaporphine (2), 3-methoxy-2'-formyl oxohemandalin (3), (-)-9-(2'-methoxycarbonyl-5', 6 '-dimethoxyphenoxy)-1, 2, 3, 10-tetramethoxy aporphine (4), (-)-2'-methoxycarbonyl thaliadin (5), (-)-9-(2'-methoxyethy1-5', 6'-dimethoxyphenoxy)-1, 2, 3, 10-tetramethoxy aporphine (6), (-)-3-methoxy hydroxyhemandalinol (7), together with six known isoquinoline alkaloids (8-13) were isolated from the roots of Thalictrum foetidum. Their structures were elucidated by extensive spectroscopic measurements. Compounds 1 and 2 showed significant selective cytotoxicity against glioma stem cells (GSC-3(#) and GSC-18(#) ) with IC50 values ranging from 2.36 to 5.37 mu g.mL(-1). |
| 关键词 | Thalictrum foetidum Aporphine alkaloids Selective cytotoxicity Glioma stem cells |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000485870100007 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/68651 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Zhao Xu-Dong; Luo Xiao-Dong |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, Key Lab Phytochem & Plant Resources West China, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Zool, Key Lab Bioact Peptides Yunnan Prov, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China 3.Yunnan Univ, Sch Chem Sci & Technol, Minist Educ & Yunnan Prov, Key Lab Med Chem Nat Resource, Kunming 650091, Yunnan, Peoples R China 4.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Yunnan, Peoples R China 5.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Yunnan, Peoples R China 6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ding Cai-Feng,Dai Zhi,Yu Hao-Fei,et al. New aporphine alkaloids with selective cytotoxicity against glioma stem cells from Thalictrum foetidum[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2019,17(9):698-706. |
| APA | Ding Cai-Feng,Dai Zhi,Yu Hao-Fei,Zhao Xu-Dong,&Luo Xiao-Dong.(2019).New aporphine alkaloids with selective cytotoxicity against glioma stem cells from Thalictrum foetidum.CHINESE JOURNAL OF NATURAL MEDICINES,17(9),698-706. |
| MLA | Ding Cai-Feng,et al."New aporphine alkaloids with selective cytotoxicity against glioma stem cells from Thalictrum foetidum".CHINESE JOURNAL OF NATURAL MEDICINES 17.9(2019):698-706. |
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