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Synthesis and Anticancer Activity of Glucosylated Podophyllotoxin Derivatives Linked via 4 beta-Triazole Rings 期刊论文
MOLECULES, 2013, 卷号: 18, 期号: 11, 页码: 13992-14012
作者:  Zi, Cheng-Ting;  Xu, Feng-Qing;  Li, Gen-Tao;  Li, Yan;  Ding, Zhong-Tao;  Zhou, Jun;  Jiang, Zi-Hua;  Hu, Jiang-Miao
浏览  |  Adobe PDF(404Kb)  |  收藏  |  浏览/下载：194/52  |  提交时间：2015/05/13
Podophyllotoxin  4 Beta-triazole Ring  Click Chemistry  Anticancer Activity  
Identification of two novel inhibitors of mTOR signaling pathway based on high content screening 期刊论文
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2013, 卷号: 72, 期号: 4, 页码: 799-808
作者:  Yan, Juming;  Zhou, Hongyu;  Kong, Lingmei;  Zhang, Jing;  Zhao, Qinshi;  Li, Yan
Adobe PDF(1971Kb)  |  收藏  |  浏览/下载：687/105  |  提交时间：2013/11/12
Mtor Signaling  Inhibitor  High Content Screening  Cancer  Apoptosis  
Two mixed-NH3/amine platinum (II) anticancer complexes featuring a dichloroacetate moiety in the leaving group 期刊论文
SCIENTIFIC REPORTS, 2013, 卷号: 3, 页码: 2464
作者:  Liu, Weiping;  Su, Jia;  Jiang, Jing;  Li, Xingyao;  Ye, Qingsong;  Zhou, Hongyu;  Chen, Jialin;  Li, Yan
浏览  |  Adobe PDF(639Kb)  |  收藏  |  浏览/下载：333/51  |  提交时间：2013/10/16
Cancer-cells  Agents  Apoptosis  Toxicity  Drugs  
Trichothecin Induces Cell Death in NF-kappa B Constitutively Activated Human Cancer Cells via Inhibition of IKK beta Phosphorylation 期刊论文
PLOS ONE, 2013, 卷号: 8, 期号: 8, 页码: e71333
作者:  Su, Jia;  Zhao, Peiji;  Kong, Lingmei;  Li, Xingyao;  Yan, Juming;  Zeng, Ying;  Li, Yan
Adobe PDF(1124Kb)  |  收藏  |  浏览/下载：330/65  |  提交时间：2013/11/12
Colitis-associated Cancer  Multiple-myeloma Cells  P65 Phosphorylation  Endophytic Fungus  Kinase-activity  Tumor-growth  In-vitro  Pathway  Apoptosis  Inflammation  
Bioactive ent-Kaurane Diterpenoids from Isodon rosthornii 期刊论文
JOURNAL OF NATURAL PRODUCTS, 2013, 卷号: 76, 期号: 7, 页码: 1267-1277
作者:  Zhan, Rui;  Li, Xiao-Nian;  Du, Xue;  Wang, Wei-Guang;  Dong, Ke;  Su, Jia;  Li, Yan;  Pu, Jian-Xin;  Sun, Han-Dong
浏览  |  Adobe PDF(448Kb)  |  收藏  |  浏览/下载：490/237  |  提交时间：2013/10/16
Lasiocarpus Hayata Kudo  Nf-kappa-b  Leukemic-cells  Terpenoids  Rubescens  Differentiation  Cytotoxicity  Constituents  Pharicin  
ent-Atisane and ent-kaurane diterpenoids from Isodon rosthornii 期刊论文
FITOTERAPIA, 2013, 卷号: 88, 页码: 76-81
作者:  Zhan, Rui;  Li, Xiao-Nian;  Du, Xue;  Wang, Wei-Guang;  Dong, Ke;  Su, Jia;  Li, Yan;  Pu, Jian-Xin;  Sun, Han-Dong
浏览  |  Adobe PDF(560Kb)  |  收藏  |  浏览/下载：476/49  |  提交时间：2013/10/16
Isorosthornins D-g  Diterpenoids  Isodon Rosthornii  
Dual-Functional abeo-Taxane Derivatives Destabilizing Microtubule Equilibrium and Inhibiting NF-kappa B Activation 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2013, 卷号: 56, 期号: 11, 页码: 4749-4757
作者:  Zhao, Yu;  Su, Jia;  Goto, Masuo;  Morris-Natschke, Susan L.;  Li, Yan;  Zhao, Qin-Shi;  Yao, Zhu-Jun;  Lee, Kuo-Hsiung
浏览  |  Adobe PDF(531Kb)  |  收藏  |  浏览/下载：322/70  |  提交时间：2013/10/16
Natural-products  Biological-activity  Cancer-therapy  Paclitaxel  Taxol  Resistance  Drugs  Chemotherapy  Parthenolide  Brevifoliol  
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua
浏览  |  Adobe PDF(6299Kb)  |  收藏  |  浏览/下载：275/45  |  提交时间：2015/05/14
One Of The Major compOnents Isolated From The Traditional  2-methyl-1  Chinese Medicine Rubia Yunnanensis  3  Exhibited Inhibitory Activity On The proliferatiOn Of Several  6-trihydroxy-9  HumAn CAncer Cell Lines. The Results From An Annexin V-fitc (fluoresein-5-isothiocyAnate) Apoptosis Assay  10-anthraquinone (Mta)  And Dna Content Analysis Showed That Mta Exerted Cytotoxicity Via Apoptosis Induction And G2/m Cell Cycle  Arrest In Human Cervical carcInoma Hela Cells. Further  Mta Was Found To Induce apopTosis Of Hela Cells  Through The MITochondria-mediated Pathway. It Caused The Translocation Of Bax To The mITochondria And  Release Of Cytochrome c Into The Cytosol  Which Caused The Cleavage Of Caspase And Poly(Adp-ribose)  Polymerase And Finally Triggered The Apoptosis. furThermore  The P53/p21/cdc2-cyclin B1 Signaling Was  Found Related To The G2/m Arrest Caused By Mta. The Over-expression Of P21 And Down-expression Of  Cyclin B1 Caused By Mta Inactivated The cdc2-Cyclin B1 Complex Of G2/m Checkpoint And Finally Caused  The G2/m Arrest In Hela Cells. ThIs Study Demonstrated That Mta Is a Potential Anti-cancer Component Of  R. Yunnanensis  a Folk Anti-cancer Herb Used In Yunnan  China.  
Cytotoxic Cycloartane Triterpenes of the Traditional Chinese Medicine "Shengma" (Cimicifuga dahurica) 期刊论文
PLANTA MEDICA, 2013, 卷号: 79, 期号: 1, 页码: 60-69
作者:  Nian, Yin;  Wang, Hai-Yan;  Zhou, Lin;  Su, Jia;  Li, Yan;  Qiu, Ming-Hua
Adobe PDF(185Kb)  |  收藏  |  浏览/下载：662/79  |  提交时间：2013/03/18
Ranunculaceae  Cimicifuga Dahurica  Cycloartane Triterpenes  Cytotoxicity  Structure-activity Relationships  
Cytotoxic Cycloartane Triterpenes of the TraditionalChinese Medicine “Shengma” (Cimicifuga dahurica) 期刊论文
Planta Med, 2013, 卷号: 79, 期号: 0, 页码: 60–69
作者:  Yin Nian;  Hai-YanWang;  Lin Zhou;  Jia Su;  Yan Li;  Ming-Hua Qiu
Adobe PDF(185Kb)  |  收藏  |  浏览/下载：70/1  |  提交时间：2017/07/24
Ranunculaceae  Cimicifuga Dahurica  Cycloartane Triterpenes  Cytotoxicity  Structure‑activity Relationships