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中国科学院昆明植物研究所知识管理系统
Knowledge Management System of Kunming Institute of Botany,CAS
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发表日期:2013
作者:李艳
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Synthesis and Anticancer Activity of Glucosylated Podophyllotoxin Derivatives Linked via 4 beta-Triazole Rings
期刊论文
MOLECULES, 2013, 卷号: 18, 期号: 11, 页码: 13992-14012
作者:
Zi, Cheng-Ting
;
Xu, Feng-Qing
;
Li, Gen-Tao
;
Li, Yan
;
Ding, Zhong-Tao
;
Zhou, Jun
;
Jiang, Zi-Hua
;
Hu, Jiang-Miao
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Adobe PDF(404Kb)
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浏览/下载:217/59
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提交时间:2015/05/13
Podophyllotoxin
4 Beta-triazole Ring
Click Chemistry
Anticancer Activity
Identification of two novel inhibitors of mTOR signaling pathway based on high content screening
期刊论文
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2013, 卷号: 72, 期号: 4, 页码: 799-808
作者:
Yan, Juming
;
Zhou, Hongyu
;
Kong, Lingmei
;
Zhang, Jing
;
Zhao, Qinshi
;
Li, Yan
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Adobe PDF(1971Kb)
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浏览/下载:721/116
  |  
提交时间:2013/11/12
Mtor Signaling
Inhibitor
High Content Screening
Cancer
Apoptosis
Two mixed-NH3/amine platinum (II) anticancer complexes featuring a dichloroacetate moiety in the leaving group
期刊论文
SCIENTIFIC REPORTS, 2013, 卷号: 3, 页码: 2464
作者:
Liu, Weiping
;
Su, Jia
;
Jiang, Jing
;
Li, Xingyao
;
Ye, Qingsong
;
Zhou, Hongyu
;
Chen, Jialin
;
Li, Yan
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Adobe PDF(639Kb)
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浏览/下载:349/57
  |  
提交时间:2013/10/16
Cancer-cells
Agents
Apoptosis
Toxicity
Drugs
Trichothecin Induces Cell Death in NF-kappa B Constitutively Activated Human Cancer Cells via Inhibition of IKK beta Phosphorylation
期刊论文
PLOS ONE, 2013, 卷号: 8, 期号: 8, 页码: e71333
作者:
Su, Jia
;
Zhao, Peiji
;
Kong, Lingmei
;
Li, Xingyao
;
Yan, Juming
;
Zeng, Ying
;
Li, Yan
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Adobe PDF(1124Kb)
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浏览/下载:346/69
  |  
提交时间:2013/11/12
Colitis-associated Cancer
Multiple-myeloma Cells
P65 Phosphorylation
Endophytic Fungus
Kinase-activity
Tumor-growth
In-vitro
Pathway
Apoptosis
Inflammation
Bioactive ent-Kaurane Diterpenoids from Isodon rosthornii
期刊论文
JOURNAL OF NATURAL PRODUCTS, 2013, 卷号: 76, 期号: 7, 页码: 1267-1277
作者:
Zhan, Rui
;
Li, Xiao-Nian
;
Du, Xue
;
Wang, Wei-Guang
;
Dong, Ke
;
Su, Jia
;
Li, Yan
;
Pu, Jian-Xin
;
Sun, Han-Dong
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Adobe PDF(448Kb)
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浏览/下载:516/246
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提交时间:2013/10/16
Lasiocarpus Hayata Kudo
Nf-kappa-b
Leukemic-cells
Terpenoids
Rubescens
Differentiation
Cytotoxicity
Constituents
Pharicin
ent-Atisane and ent-kaurane diterpenoids from Isodon rosthornii
期刊论文
FITOTERAPIA, 2013, 卷号: 88, 页码: 76-81
作者:
Zhan, Rui
;
Li, Xiao-Nian
;
Du, Xue
;
Wang, Wei-Guang
;
Dong, Ke
;
Su, Jia
;
Li, Yan
;
Pu, Jian-Xin
;
Sun, Han-Dong
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Adobe PDF(560Kb)
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浏览/下载:494/52
  |  
提交时间:2013/10/16
Isorosthornins D-g
Diterpenoids
Isodon Rosthornii
Dual-Functional abeo-Taxane Derivatives Destabilizing Microtubule Equilibrium and Inhibiting NF-kappa B Activation
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2013, 卷号: 56, 期号: 11, 页码: 4749-4757
作者:
Zhao, Yu
;
Su, Jia
;
Goto, Masuo
;
Morris-Natschke, Susan L.
;
Li, Yan
;
Zhao, Qin-Shi
;
Yao, Zhu-Jun
;
Lee, Kuo-Hsiung
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Adobe PDF(531Kb)
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浏览/下载:352/84
  |  
提交时间:2013/10/16
Natural-products
Biological-activity
Cancer-therapy
Paclitaxel
Taxol
Resistance
Drugs
Chemotherapy
Parthenolide
Brevifoliol
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells
期刊论文
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:
Zeng, Guang-Zhi
;
Fan, Jun-Ting
;
Xu, Jun-Ju
;
Li, Yan
;
Tan, Ning-Hua
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Adobe PDF(6299Kb)
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浏览/下载:318/50
  |  
提交时间:2015/05/14
One Of The Major compOnents Isolated From The Traditional
2-methyl-1
Chinese Medicine Rubia Yunnanensis
3
Exhibited Inhibitory Activity On The proliferatiOn Of Several
6-trihydroxy-9
HumAn CAncer Cell Lines. The Results From An Annexin V-fitc (fluoresein-5-isothiocyAnate) Apoptosis Assay
10-anthraquinone (Mta)
And Dna Content Analysis Showed That Mta Exerted Cytotoxicity Via Apoptosis Induction And G2/m Cell Cycle
Arrest In Human Cervical carcInoma Hela Cells. Further
Mta Was Found To Induce apopTosis Of Hela Cells
Through The MITochondria-mediated Pathway. It Caused The Translocation Of Bax To The mITochondria And
Release Of Cytochrome c Into The Cytosol
Which Caused The Cleavage Of Caspase And Poly(Adp-ribose)
Polymerase And Finally Triggered The Apoptosis. furThermore
The P53/p21/cdc2-cyclin B1 Signaling Was
Found Related To The G2/m Arrest Caused By Mta. The Over-expression Of P21 And Down-expression Of
Cyclin B1 Caused By Mta Inactivated The cdc2-Cyclin B1 Complex Of G2/m Checkpoint And Finally Caused
The G2/m Arrest In Hela Cells. ThIs Study Demonstrated That Mta Is a Potential Anti-cancer Component Of
R. Yunnanensis
a Folk Anti-cancer Herb Used In Yunnan
China.
Cytotoxic Cycloartane Triterpenes of the TraditionalChinese Medicine “Shengma” (Cimicifuga dahurica)
期刊论文
Planta Med, 2013, 卷号: 79, 期号: 0, 页码: 60–69
作者:
Yin Nian
;
Hai-YanWang
;
Lin Zhou
;
Jia Su
;
Yan Li
;
Ming-Hua Qiu
Adobe PDF(185Kb)
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  |  
浏览/下载:77/1
  |  
提交时间:2017/07/24
Ranunculaceae
Cimicifuga Dahurica
Cycloartane Triterpenes
Cytotoxicity
Structure‑activity Relationships
Cytotoxic Cycloartane Triterpenes of the Traditional Chinese Medicine "Shengma" (Cimicifuga dahurica)
期刊论文
PLANTA MEDICA, 2013, 卷号: 79, 期号: 1, 页码: 60-69
作者:
Nian, Yin
;
Wang, Hai-Yan
;
Zhou, Lin
;
Su, Jia
;
Li, Yan
;
Qiu, Ming-Hua
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  |  
Adobe PDF(185Kb)
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浏览/下载:692/85
  |  
提交时间:2013/03/18
Ranunculaceae
Cimicifuga Dahurica
Cycloartane Triterpenes
Cytotoxicity
Structure-activity Relationships