| Cytotoxic Cycloartane Triterpenes of the Traditional Chinese Medicine "Shengma" (Cimicifuga dahurica) | |
Nian, Yin2 ; Wang, Hai-Yan2; Zhou, Lin; Su, Jia2; Li, Yan; Qiu, Ming-Hua1
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| 通讯作者 | Qiu, MH (reprint author), Chinese Acad Sci, Grad Sch, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, 132 Lanhei Rd, Kunming 650204, Peoples R China.，mhchiu@mail.kib.ac.cn |
| 2013 | |
| 发表期刊 | PLANTA MEDICA
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| ISSN | 0032-0943 |
| 卷号 | 79期号:1页码:60-69 |
| 摘要 | Twelve new 9,19-cycloartane triterpenes (1-12), together with fourteen known compounds (13-26), were isolated from the roots of Cimicifuga dahurica. Their structures were determined by application of spectroscopic analyses and chemical methods. Biological evaluation of the compounds against human HL-60, SMMC-7721, A549, MCF-7, and SW-480 cell lines indicated that cimigenol-type glycosides (1-3, 19, and 20) showed broad-spectrum and moderate cytotoxicities, with IC50 values ranging from 4.2 to 14.5 mu M. Meanwhile, cimigenol-type aglycones (6-8, 15, 16, and 18) exhibited broad-spectrum and week cytotoxicities, having IC50 values around 20 mu M. In addition, the key points of the structure-activity relationships of aglycones with a cimigenol skeleton were discussed. |
| 关键词 | Ranunculaceae Cimicifuga Dahurica Cycloartane Triterpenes Cytotoxicity Structure-activity Relationships |
| 学科领域 | Plant Sciences ; Pharmacology & Pharmacy |
| DOI | 10.1055/s-0032-1328019 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000313055500011 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/16238 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Grad Sch, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Nian, Yin,Wang, Hai-Yan,Zhou, Lin,et al. Cytotoxic Cycloartane Triterpenes of the Traditional Chinese Medicine "Shengma" (Cimicifuga dahurica)[J]. PLANTA MEDICA,2013,79(1):60-69. |
| APA | Nian, Yin,Wang, Hai-Yan,Zhou, Lin,Su, Jia,Li, Yan,&Qiu, Ming-Hua.(2013).Cytotoxic Cycloartane Triterpenes of the Traditional Chinese Medicine "Shengma" (Cimicifuga dahurica).PLANTA MEDICA,79(1),60-69. |
| MLA | Nian, Yin,et al."Cytotoxic Cycloartane Triterpenes of the Traditional Chinese Medicine "Shengma" (Cimicifuga dahurica)".PLANTA MEDICA 79.1(2013):60-69. |
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