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题名: Cytotoxic Cycloartane Triterpenes of the Traditional Chinese Medicine "Shengma" (Cimicifuga dahurica)
作者: Nian, Yin2; Wang, Hai-Yan2; Zhou, Lin; Su, Jia2; null(李艳); null(邱明华)1
刊名: PLANTA MEDICA
关键词: Ranunculaceae ; Cimicifuga dahurica ; cycloartane triterpenes ; cytotoxicity ; structure-activity relationships
英文摘要: Twelve new 9,19-cycloartane triterpenes (1-12), together with fourteen known compounds (13-26), were isolated from the roots of Cimicifuga dahurica. Their structures were determined by application of spectroscopic analyses and chemical methods. Biological evaluation of the compounds against human HL-60, SMMC-7721, A549, MCF-7, and SW-480 cell lines indicated that cimigenol-type glycosides (1-3, 19, and 20) showed broad-spectrum and moderate cytotoxicities, with IC50 values ranging from 4.2 to 14.5 mu M. Meanwhile, cimigenol-type aglycones (6-8, 15, 16, and 18) exhibited broad-spectrum and week cytotoxicities, having IC50 values around 20 mu M. In addition, the key points of the structure-activity relationships of aglycones with a cimigenol skeleton were discussed.
出版日期: 2013
卷号: 79, 期号:1, 页码:60-69
DOI标识: 10.1055/s-0032-1328019
语种: 英语
收录类别: SCI
学科分类: Plant Sciences; Pharmacology & Pharmacy
ISSN号: 0032-0943
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/16238
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Grad Sch, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
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