Cytotoxic Cycloartane Triterpenes of the Traditional Chinese Medicine "Shengma" (Cimicifuga dahurica)
Nian, Yin2; Wang, Hai-Yan2; Zhou, Lin; Su, Jia2; Li, Yan; Qiu, Ming-Hua1
2013
发表期刊PLANTA MEDICA
ISSN0032-0943
卷号79期号:1页码:60-69
摘要Twelve new 9,19-cycloartane triterpenes (1-12), together with fourteen known compounds (13-26), were isolated from the roots of Cimicifuga dahurica. Their structures were determined by application of spectroscopic analyses and chemical methods. Biological evaluation of the compounds against human HL-60, SMMC-7721, A549, MCF-7, and SW-480 cell lines indicated that cimigenol-type glycosides (1-3, 19, and 20) showed broad-spectrum and moderate cytotoxicities, with IC50 values ranging from 4.2 to 14.5 mu M. Meanwhile, cimigenol-type aglycones (6-8, 15, 16, and 18) exhibited broad-spectrum and week cytotoxicities, having IC50 values around 20 mu M. In addition, the key points of the structure-activity relationships of aglycones with a cimigenol skeleton were discussed.
关键词Ranunculaceae Cimicifuga Dahurica Cycloartane Triterpenes Cytotoxicity Structure-activity Relationships
资助信息National Natural Science Foundation of China [U1132604]; Knowledge Innovation Program of the CAS [KZCX2-XB2-15-03, KSCX2-EW-R-15]; Top Talents Program of Yunnan province [2009C1120]; Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China [P2010-ZZ14]
学科领域Plant Sciences ; Pharmacology & Pharmacy
DOI10.1055/s-0032-1328019
收录类别SCI
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000313055500011
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/16238
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Grad Sch, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
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Nian, Yin,Wang, Hai-Yan,Zhou, Lin,et al. Cytotoxic Cycloartane Triterpenes of the Traditional Chinese Medicine "Shengma" (Cimicifuga dahurica)[J]. PLANTA MEDICA,2013,79(1):60-69.
APA Nian, Yin,Wang, Hai-Yan,Zhou, Lin,Su, Jia,Li, Yan,&Qiu, Ming-Hua.(2013).Cytotoxic Cycloartane Triterpenes of the Traditional Chinese Medicine "Shengma" (Cimicifuga dahurica).PLANTA MEDICA,79(1),60-69.
MLA Nian, Yin,et al."Cytotoxic Cycloartane Triterpenes of the Traditional Chinese Medicine "Shengma" (Cimicifuga dahurica)".PLANTA MEDICA 79.1(2013):60-69.
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