| Two mixed-NH3/amine platinum (II) anticancer complexes featuring a dichloroacetate moiety in the leaving group | |
Liu, Weiping1; Su, Jia2,3; Jiang, Jing1; Li, Xingyao2,3; Ye, Qingsong1; Zhou, Hongyu2; Chen, Jialin1; Li, Yan2
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| 通讯作者 | Li, Y (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China. ; liyanb@mail.kib.ac.cn |
| 2013-08-19 | |
| 发表期刊 | SCIENTIFIC REPORTS
 |
| ISSN | 2045-2322 |
| 卷号 | 3页码:2464 |
| 摘要 | Two mixed-NH3/amine platinum (II) complexes of 3-dichoroacetoxylcyclobutane-1, 1-dicarboxylate have been prepared in the present study and characterized by elemental analysis and IR, HPLC-MS and(1)H, C-13-NMR. The complexes exist in equilibrium between two position isomeric forms and undergo hydrolysis reaction in aqueous solution, releasing the platinum pharmacophores and dichloroacetate which is a small-molecular cell apoptosis inducer. Both complexes were evaluated for in vitro cytotoxic profile in A549, SGC-7901 and SK-OV-3 caner cells as well as in BEAS-2B normal cells. They exhibit markedly cytoxicity toward cancer cells by selectively inducing the apoptosis of cancer cells, whereas leaving normal cells less affected. They have also the ability to overcome the resistance of SK-OV-3 cancer cells to cisplatin. Our findings offer an alternative novel way to develop platinum drugs which can both overcome the drug resistance and selectively target tumor cells. |
| 关键词 | Cancer-cells Agents Apoptosis Toxicity Drugs |
| 学科领域 | Multidisciplinary Sciences |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000323194900001 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/16701 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Kunming Inst Precious Met, State Key Lab Platinum Grp Met, Kunming 650106, Yunnan, Peoples R China 2.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Weiping,Su, Jia,Jiang, Jing,et al. Two mixed-NH3/amine platinum (II) anticancer complexes featuring a dichloroacetate moiety in the leaving group[J]. SCIENTIFIC REPORTS,2013,3:2464. |
| APA | Liu, Weiping.,Su, Jia.,Jiang, Jing.,Li, Xingyao.,Ye, Qingsong.,...&Li, Yan.(2013).Two mixed-NH3/amine platinum (II) anticancer complexes featuring a dichloroacetate moiety in the leaving group.SCIENTIFIC REPORTS,3,2464. |
| MLA | Liu, Weiping,et al."Two mixed-NH3/amine platinum (II) anticancer complexes featuring a dichloroacetate moiety in the leaving group".SCIENTIFIC REPORTS 3(2013):2464. |
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